Conserved Protein Domain Family
NBD94
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pfam16830: NBD94 
Nucleotide-Binding Domain 94 of RH
NBD94 is a domain on one of the reticulocyte binding protein homolog family or RH proteins expressed by the malaria parasite merozoite. RH proteins recognize erythrocytes and are important in virulence. This domain has been shown to exhibit selective binding to ATP and ADP. Binding of ATP or ADP induces nucleotide-dependent structural changes in the C-terminal hinge-region of NBD94 that directly impact on the ability of the RH to bind to the red blood cells.
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Statistics
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PSSM-Id: 407079
Aligned: 4 rows
Threshold Bit Score: 78.6527
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDL44595 1050 QEKDKQIVYNTNRgdIEKVYKNIRDMYNELDDVEKEETTSNEVDNIEMQYDRLLINLLVQKINEENTKAKGLMEEIKSYI 1129
Q7RIT2    265 ENKQETIVSKIDK--TKSIYENMNKLVSEITEIKNNTISLKNIQNINLSYKQSLNKLFGDQINKEKTNSENMIKSIEKCK 342  Plasmodium yoelii...
Q7RBW8    469 EKKIENIVEKIDK--KKNIYKEIDKLLNEISKIENDKTSLEKLKNINLSYGKSLGNLFLQQIDEEKKKAEHTIKAMEAYI 546  Plasmodium yoelii...
AEX57207  328 KNKTAEFNAKKDS--LEKIHQQMENTHKELESMENEKIPINDINQMEIEYARILIHHMVQQIGEKKERSKIILEEIKTTI 405  malaria parasite ...

EDL44595 1130 ENIESVQAKMSDE 1142
Q7RIT2    343 TEFDDIKNKLIAE 355  Plasmodium yoelii yoelii
Q7RBW8    547 DDLDNIKKKSQEI 559  Plasmodium yoelii yoelii
AEX57207  406 ASIDQAKKNIPPE 418  malaria parasite P. vivax
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