Conserved Protein Domain Family
PSY3

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pfam16836: PSY3 
Shu complex component Psy3, DNA-binding description
PSY3 is one of the components of the yeast Shu complex that maintains genomic stability during replication. Psy3 complexes first with Cms2, and their L2 loops confer the DNA-binding activity to the Shu complex. The Shu complex binds to recombination sites and is required for Rad51 assembly and function during meiosis. The heterodimer of Psy3-Csm2 stabilizes the Rad51-single-stranded DNA complex independently of nucleotide cofactor because Psy3-Csm2 is a structural mimic of the Rad51-dimer.
Statistics
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PSSM-Id: 407083
Aligned: 12 rows
Threshold Bit Score: 181.478
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCD27101       7 CRIYPLANYIRPELKFINISNDLIinnnksiisvndhldddknDDNNTNKVALAHLIEHE------FKLTTFKKKLLIdl 80 
Q6FRY6         7 CRIYPISSFCATTETYFKIPEDLVnq----------------hLALRTRKLGHIHVVEHS------FRLSKVKKKLIT-- 62  [Candida] glabrata
CCC72111      20 CRVYPLSNFYHPSPQSITLPNTLIs-----------------nTDNDKPHIGLLHLIEHD------FKMSNFKKQLF--- 73 
XP_003681601   7 CRIYPLSSFYHPAQWFIELAGLVT-------------------TDNELKPVGLLHLIEHS------FKTSTFKRDLFLq- 60 
XP_002495268   7 CRVYPISNFYHAVPQSLTLPSCIG-----------------------SHCVSFVHLIEHN------FKFTPFKRQIWNqc 57 
XP_003955181   7 CRIYPLSNFLKPKRNAINLEGLNInns--------------ndITINNNESQSLHLIEHS------FRKSKFKEQLV--- 63 
XP_003645288   7 CKVYPLDRFLKPHLYTLNWLPELS-------------------VDDKRKPVRFLHIVEKSmglldrWKASFLRQLL---- 63 
XP_002999497   7 CKIYSLARFVHPRQHSLDWLAPGT---------------------APRKSVHVVHVVERTmgelaaWRPRTLARLL---- 61 
Q6CPY4         7 CKVYSLDQFTSPYQYTCEV---------------------------NGKKCTRIHVVQES------LRGNGKTRTIVNt- 52  Kluyveromyces l...
EDK42648       1 MKISNLTDHIEFQEYSVDIPSQTG---------------------------EPIITIKRQetclvlAENQRIIQTVFVkv 53 
CCK69025       7 CKVYPLGKYITPAQRSLDLPPAGHti----------------tNGKPHSTHSRVHIIVKD------IRHGQIIQDIL--- 61 
XP_004178125   7 CKIYPLSKFYKPNYQYYQLPPGIKp-----------------nENLDTSKISKLHLIEYG------FEITPLKRSLLTtm 63 
CCD27101      81 itipNHEKNGKNSYLII-----------DISSTWKQYLIelfdrenNQTNFTTSINYMNSFSILNMDGLINFLMQLNGS- 148
Q6FRY6        63 ----TNLDENSGLILLI-----------DVISCWKQFAR-------SLVNNGQSIAYLSSASLCQFDGLLNFLGQLIDS- 119 [Candida] glabrata
CCC72111      74 ----NHLTTSNASYLII-----------DITSTWKRFLL-------SSSSASASLMYMNSTSILSFEGLINYLVQLNDH- 130
XP_003681601  61 ----cAGDRDDSSILVI-----------DIVSEWKSLLK----------NYGVGVHVMSSTSILNIDGLISFLLQLNES- 114
XP_002495268  58 ---iECSVNDGSSILVI-----------DIISEWKKIIQ----------ENSQGVHYMNSTSICNMEGLQNFLMQLQAS- 112
XP_003955181  64 -------SNNFEHIIII-----------DIISIWQD----------------DKFNVIN--SIYTFNELINFLTKFNDS- 106
XP_003645288  64 ------DQNDPATVLVI-----------DAISIWSRMLP---------HKSESQVHYLNNPSILQFSGLVGFLAQLCES- 116
XP_002999497  62 ---------EGGAVVIV-----------DCVAVWGRAVA--------QHASSGRIHYVRDAGVLSFSGLLGFLAQLADA- 112
Q6CPY4        53 ---vREQCEGNGLILNIssmprndhndnDLLETYPEFQQ-------------------TNLSMLQFDSFIQFMSQLCTD- 109 Kluyveromyces l...
EDK42648      54 lnkvRADSSTNSILINCegq-----------------------eyfPRREFQNSESITTEINVRTVQDLISALENILAC- 109
CCK69025      62 -----TQSAGHGCVLVV-----------Dnygn----------nhpPSAKDTHTVRHLVSST--RVEDLTAYLRDVPSQl 113
XP_004178125  64 -----lMMEDVGNVLII-----------DIVSIWLGTIEm------MNMKQKKKINYLNCIS--NIKELNNFLSQLIET- 118
CCD27101     149 PIDALK-RCQQypstsSDSIDQy---QLSGIIIDNLS-Yi-----------------sSSSSSst---sTFPLLLKLLKL 203
Q6FRY6       120 PDEALK-RCIF-----TDSYSClq-qPLTGIIIDNLS-Y-------------------YQTPVam---rEFSALQKMLKS 169 [Candida] glabrata
CCC72111     131 PTTALQ-RSLS-----INNEPLqltlPLSGIIIDNLS-Yl-----------------pQDPPQ-------FKILTNILKL 179
XP_003681601 115 PREALK-RCQR-----RDSLSK----QLSGIVIDNIS-Yi-----------------vHDPGS-------YNLLLRTLKM 159
XP_002495268 113 PLEALQ-RCLI-----KDRLDK----QISGIIIDNLS-Yl-----------------aHDLSS-------YSALIKILKQ 157
XP_003955181 107 PLATLS-EY-------GISMDT-----VEGIMIDNLS-Yi-----------------gNLNNKs------IVILIKILKL 149
XP_003645288 117 PDLALRsRCDI-----HASLDA----PLKTVILDNLSaYy-----------------fQENAS-------LETLRKLLET 163
XP_002999497 113 PAATLRrRCRA-----PATAPA----PLAAVVLDNISaYr------------------APPAA-------LGALRRALEH 158
Q6CPY4       110 PVTALS-RCQPqn--sETSTSK----QLAWVLIDNLS-Hl-----------------sMDPKF------DAKLLNRSIRL 158 Kluyveromyces l...
EDK42648     110 TSDAIM------------NMER----ELRAILISNISsFywtlhllndenyqnlgfktYIPPSn-----IYLRLSHLFKH 168
CCK69025     114 PTEA---RTM----------------PLQGIIVDNLSlCr-----------------rSRGPG------ADAQLLETLRK 151
XP_004178125 119 PIVALR-RCQQ-----FENVDEviqrRLDGIFIDNVS-Yl-----------------qDFNEDqkgnsqMYDELNKMIRK 174
CCD27101     204 LRKSFGCWIFTTSYGISYYKGIENSL---ESSPSSSSIHLqqhskklpTYFPESFINGMDMILLHETE 268
Q6FRY6       170 LRSTFGCWTMTTSYGLEYYNGVEGGT---STLYTSSGTSF--------TRLPVSYIKDTDLVLMRDTE 226 [Candida] glabrata
CCC72111     180 LRKSLGCWIMTTSYGLEYNQGIENTI---STSASNSN-----------TYIPLNYTKEMDIVLLHERD 233
XP_003681601 160 LRNTFGCWIITISYGLEFYNGVENST---ASLYRSGSI----------TRVPISYTNEMDAMIIRDTD 214
XP_002495268 158 LRRTFGCWILTIGYGLEYYDGVENST---STPNRTGAL----------TKLPASYINEMDVIILRETA 212
XP_003955181 150 IQINFGCFILSTSYGLEYYEGIEN-------FQRMKNLNLky-----pTLLPMNYLLEMDTILLRETG 205
XP_003645288 164 LHATLGCAVVTFGYGIEYYEGVDNTY---PT--RPSEIKGpw-----pTRLDYSYLKAMDSVLVFTQD 221
XP_002999497 159 LQLAHGCAVLTVGYGIEYYEGVESSF---PT--RAGEV-Gpw-----pTRLDHAYLASMDAVVVPATE 215
Q6CPY4       159 VQQTFGSVVISTSLPLSFHGGIESTFkhqSTKCASGD-----------RLLP--YFNESDIIL----- 208 Kluyveromyces lactis
EDK42648     169 IARKYHCTVIVFGFDFHFDCGLSA-----DKYCPQSDLQKl-------SKLPSLFLSSFTHIVHKgrv 224
CCK69025     152 LQRRYGCWVVTVSYGIGF-----------ATAGGQQLAQTay-----pTSLPLQYLNECDTVLYTETR 203
XP_004178125 175 VREVFGCWVVSISYGNEYYEGVEGCL---NV--KSHSI----------SGVPISFLNGMDMIVLRESE 227
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