Conserved Protein Domain Family
CYCc

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smart00044: CYCc 
Adenylyl- / guanylyl cyclase, catalytic domain
Present in two copies in mammalian adenylyl cyclases. Eubacterial homologues are known. Two residues (Asn, Arg) are thought to be involved in catalysis. These cyclases have important roles in a diverse range of cellular processes.
Statistics
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PSSM-Id: 214485
Aligned: 32 rows
Threshold Bit Score: 149.715
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAA93421      960 DERKRNESLLLQLLPKSVANSLKN-Gq----------------------------------------------------- 985  nematode
EAW61044       33 DENEKQERLLMSLLPRNVAMEMKE-Dflkpp------------------------------------------------- 62   human
NP_012529    1611 YGCTENITILCLALYENIQQQNRF-Tlnknslmtrrs------------------------------------------- 1646 Saccharomyces...
AAA88525        1 MREWCMLRESRTNTPRRAAERGKRpGg----------------------------------------------------- 27   Sinorhizobium...
NP_596159    1261 AYGAEKNVLVVIVELNGLFEENSL-Nfnqlrgdektlaiseknd------------------------------------ 1303 Schizosacchar...
XP_365053    1655 MILLATSELWEHLAPELIVDIARQ-Ergdlmratqklrdlaiaygstnkimimmisvadlkrrtertrinrgqsmsihnl 1733 Magnaporthe g...
NP_441146      16 LEIDSNETILDALLKGDIAHISVC-Ggkancstcrimvldgikncspptsieqalakkldfp------------fhvrla 82   Synechocystis...
XP_761379    1966 ARTQRNDPMIAAQKLRDFAISYGA-Eesimvmvisvgdlfyrsdqrnggglnfas------------------------- 2019 Ustilago mayd...
Q27675        850 IEILSIQRMLDPTVPQLSSPSTPT-Meyrprqrshaltpaqrngliagcv------------------------------ 898  Leishmania do...
YP_003953099  196 lkrarlgryfspavaeRLQDLDRS-------------------------------------------------------- 219  Stigmatella a...
AAA93421      986 -----------------------------PVDAEFYDSVSIYFSDIVGFTALSsKSTPLQVVNMLNNLYTNFD----TII 1032 nematode
EAW61044       63 ------------------------erifhKIYIQRHDNVSILFADIVGFTGLAsQCTAQELVKLLNELFGKFD----ELA 114  human
NP_012529    1647 ------------------tfedttlrrlqPEISPPTGNLAMVFTDIKSSTFLWe-LFPNAMRTAIKTHNDIMR----RQL 1703 Saccharomyces...
AAA88525       28 ----------------------------sSVRGGERRIVTALCYDLVGSTDLM---HVMDIED-YQELMSAFQlaskQAI 75   Sinorhizobium...
NP_596159    1304 -----------nmsfvqdlpddsslarmnREVSPPKGCIAMVFTDIKNSTLLW-ERHPIAMRSAIKTHNTIMR----RQL 1367 Schizosacchar...
XP_365053    1734 slhgeqykfptrgrrkkdqvmdstlqrleAEVPAPTGMIAIVFTDIKNSTNL--WETYPAAMRSAIRLHNEMM----RRQ 1807 Magnaporthe g...
NP_441146      83 cqtklsnsatirrlvldegdidlidhqltTGAINTERNVALLMANIRGATNFDeVNFPYDIVYVMGRYFSQMQ----KII 158  Synechocystis...
XP_761379    2020 -yknsdaiqkagrrfreelpgdrtlarldREVAPPIGQVALVFTDIKNSTSLWeTNNGMQTAMRLHNYLLRRQ----LRT 2094 Ustilago mayd...
Q27675        899 -----vgavvliatctlllyccmdnrnndAAPKDGDEPVTLLFTDIESSTALW-AALPQLMSDAIAAHHRVIR----QLV 968  Leishmania do...
YP_003953099  220 ------------------------------ETSPELREVTLLFADIRDFTSLSeRLRPEQVVTLLNEYYGRMV----EVV 265  Stigmatella a...
AAA93421     1033 DKFD-CYKVETIGDAYMFVSGLPEVNS-----------------------YLHAGEVASASLELLDSIKTFTVSHCp--- 1085 nematode
EAW61044      115 TENH-CRRIKILGDCYYCVSGLTQPKT------------------------DHAHCCVEMGLDMIDTITSV-AEAT---- 164  human
NP_012529    1704 RIYG-GYEVKTEGDAFMVAFPTPTSGLtwc------------------lsVQLKLLDAQWPEEITSVQDGCQVTDRngni 1764 Saccharomyces...
AAA88525       76 ASHS-GVMQHEAGDGGVALFPIELEAK------------------------DAASLAIRAGLGIVEACKRVGREAG---- 126  Sinorhizobium...
NP_596159    1368 RATG-GYEVKTEGDAFMVCFQTVPAALlwc------------------fsVQLQLLSADWPNEIVESVQGRLVLGSknev 1428 Schizosacchar...
XP_365053    1808 LRRIgGFEVKTEGDAFMVSFPTATSALlwcf---------------avqlQLLEVNWPSEMLNSLSCKPTVDKNNQv--- 1869 Magnaporthe g...
NP_441146     159 EKYG-GTISNVMGRKMLVAFGLKEFDVs---------------------aAERATWAALEMFKSVQELNTLLNQMr---- 212  Synechocystis...
XP_761379    2095 IG---GYEVKTEGDAFMVSFPSVSAALlwc------------------ftVQQQLLQEDWPREILDSEDGKEVYDQsgel 2153 Ustilago mayd...
Q27675        969 KKYG-CYEVKTIGDSFMIACRSAHSAVslaceiqtkllkhdwgtealdraYREFELARVDTLDDYEPPTARLSEEEya-a 1046 Leishmania do...
YP_003953099  266 FRHG-GTLDKFIGDALMVYFGAPIAd------------------------PAHARRGVQCALDMVQELETVNALRSar-- 318  Stigmatella a...
AAA93421     1086 -DEKLRLRIGNHTGPVVTGVVGIRm--P-RYCLFGDTVIIANMMESSGEPM--RIQISSDAYELI--------LkCGGYV 1151 nematode
EAW61044      165 -EVDLNMRVGLHTGRVLCGVLGLRk--W-QYDVWSNDVTLANVMEAAGLPG--KVHITKTTLACL--------NgDYEve 230  human
NP_012529    1765 iYQGLSVRMGIHWGCPVPELDLVTq----RMDYLGPMVNKAARVQGVADGG--QIAMSSDFYSEFn---------KIMKY 1829 Saccharomyces...
AAA88525      127 -QDDLQVRVGIATSVALVLEGSREg--WtREPVTGAALAMAARLQAITAPN--SVLVSEETRH-L--------AgRSYAF 192  Sinorhizobium...
NP_596159    1429 lYRGLSVRIGVNYGVTVSELDPIT---R-RMDYYGPVVNRTSRVVSVADGG--QIAVSAEVVSVLnqldsetmSsEKTNV 1502 Schizosacchar...
XP_365053    1870 iFKGLSVRMGIHWGEPLCEPDPIt---R-RMDYYGPMVNKASRISAVADGG--QITVSSDFISEI--------QrCLETY 1935 Magnaporthe g...
NP_441146     213 -YRPLNLSMGIHSGSVVFVPLVAAq-sT-LLTPLGEVAAIVNLLESANKLKgtQLLVSQDVYQVIkn-----qArVGNQI 284  Synechocystis...
XP_761379    2154 iHRGLSVRMGIHWGRPVCEADPIT---R-RMDYFGPMVNRAARISGAADGG--QILASKDVIKEL--------QgLLGTF 2219 Ustilago mayd...
Q27675       1047 lWCGLRVRVGIHTGLTDIRYDEVT---K-GYDYYGDTSNMAARTEAVANGG--QVVATEAAWWALs---------NDERA 1111 Leishmania do...
YP_003953099  319 gEPCLRIGVGVHTGPAVLGNIGSAtrrL-EYTAIGDTVNLASRIESLTKTR--DVPILASRATREq---------AGDTF 386  Stigmatella a...
AAA93421     1152 TE 1153 nematode
EAW61044      231 pg 232  human
NP_012529    1830 HE 1831 Saccharomyces cerevisiae S288c
AAA88525      193 VF 194  Sinorhizobium meliloti
NP_596159    1503 NE 1504 Schizosaccharomyces pombe 972h-
XP_365053    1936 QG 1937 Magnaporthe grisea 70-15
NP_441146     285 IL 286  Synechocystis sp. PCC 6803
XP_761379    2220 DE 2221 Ustilago maydis 521
Q27675       1112 GI 1113 Leishmania donovani
YP_003953099  387 LW 388  Stigmatella aurantiaca DW4/3-1
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