Conserved Protein Domain Family
Macro

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cl00019: Macro Superfamily 
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Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ADP-ribose as a ligand. Previously identified as displaying an Appr-1"-p (ADP-ribose-1"-monophosphate) processing activity, the macro domain may play roles in distinct ADP-ribose pathways, such as the ADP-ribosylation of proteins, an important post-translational modification which occurs in DNA repair, transcription, chromatin biology, and long-term memory formation, among other processes.
Links
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Taxonomy: root
PubMed: 28 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00019
PSSM Id: 320715
Name: Macro
Created: 8-Feb-2008
Updated: 19-Sep-2018
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