Conserved Protein Domain Family

cl00116: PDGF Superfamily 
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Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain
Taxonomy: root
PubMed: 14 links
Protein: Related Protein
Related Structure
Accession: cl00116
PSSM Id: 320767
Name: PDGF
Created: 8-Feb-2008
Updated: 19-Sep-2018
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