Conserved Protein Domain Family

cl00173: VIP2 Superfamily 
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VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of biological pathways distinct from classical A-B toxins. A novel family of insecticidal ADP-ribosyltransferses were isolated from Bacillus cereus during vegetative growth, where VIP1 likely targets insect cells and VIP2 ribosylates actin. VIP2 shares significant sequence similarity with enzymatic components of other binary toxins, Clostridium botulinum C2 toxin, C. perfringens iota toxin, C. piroforme toxin, C. piroforme toxin and C. difficile toxin.
Taxonomy: root
PubMed: 5 links
Protein: Related Protein
Related Structure
Accession: cl00173
PSSM Id: 320796
Name: VIP2
Created: 8-Feb-2008
Updated: 19-Sep-2018
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