1MKE,1EGX,1EVH


Conserved Protein Domain Family
WH1

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pfam00568: WH1 
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WH1 domain
WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homolog. A subset of WH1 domains has been termed a "EVH1" domain and appear to bind a polyproline motif.
Statistics
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PSSM-Id: 144235
View PSSM: pfam00568
Aligned: 8 rows
Threshold Bit Score: 142.203
Threshold Setting Gi: 159162254
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MKE_A       33 FSFLGKKC-VTMSSAVVQLYAA--DRNCmWSK-----KCSGVACLVKDNPQRSYFLRIFDIK-DGKLLWEQELYNNFVYN 103
gi 2498506   13 KRALPKASnKIIDVTVARLYIAypDKNE-WQYt----GLSGALALVDDLVGNTFFLKLVDINgHRGVIWDQELYVNFEYY 87
gi 1722836   36 FEMLGRKC-LTLATAVVQLYLAlpPGAEhWTK-----EHCGAVCFVKDNPQKSYFIRLYGLQ-AGRLLWEQELYSQLVYS 108
gi 74947648  31 FKLLGKKC-QTLNTAVVQIYKTegSAHAhWKK-----RHTGVVCFVKDSAIRSYFMRAYCLI-KNELIWEHEIYDGMEVV 103
gi 74873251   1 MG-E-----QPIFTCQAHVFHIdpKTKRtWITa---sMKAVNVSFFYDSSRNLYRIISVE---GTKAVINSTITPNMTFT 68
gi 38604639   3 TARE-----QPIFSTRAHVFQIdpATKRnWIPa---gKHALTVSYFYDATRNVYRIISIG---GAKAIINSTVTPNMTFT 71
1EGX_A        1 MS-E-----TVICSSRATVMLYddGNKR-WLPagtgpQAFSRVQIYHNPTANSFRVVGRKMQpDQQVVINCAIVRGVKYN 73
1EVH_A        1 MS-E-----QSICQARAAVMVYddANKK-WVPag-gsTGFSRVHIYHHTGNNTFRVVGRKIQ-DHQVVINCAIPKGLKYN 71
                        90       100       110
                ....*....|....*....|....*....|....*....
1MKE_A      104 SPRGYFHTFAGDTC--QVALNFANEEEAKKFRKAVTDLL 140
gi 2498506   88 QDRTFFHTFEMEEC--FAGLLFVDINEASHFLKRVQKRE 124
gi 1722836  109 TPTPFFHTFAGDDC--QAGLNFADEDEAQAFRALVQEKI 145
gi 74947648 104 KSRPFLLTFEGSDG--HVGLNFVSEEECDSFFRIVDATI 140
gi 74873251  69 QTSQKFGQWSDVRAntVYGLGFASEAELTKFVEKFQEVK 107
gi 38604639  72 KTSQKFGQWADSRAntVYGLGFGSEQQLTQFAEKFQEVK 110
1EGX_A       74 QATPNFHQWRDARQ--VWGLNFGSKEDAAQFAAGMASAL 110
1EVH_A       72 QATQTFHQWRDARQ--VYGLNFGSKEDANVFASAMMHAL 108
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