Conserved Protein Domain Family
Nup35_RRM

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pfam05172: Nup35_RRM 
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Nup53/35/40-type RNA recognition motif
Members of this family belong to the nucleor pore complex, NPC, the only gateway between the nucleus and the cytoplasm. The NPC consists of several subcomplexes each one of which is made up of multiple copies of several individual Nup, Nic or Sec protein subunits. In yeast, this Nup or nucleoporin subunit is numbered Nup53, Nup40 in Schizo. pombe and in vertebrates as Nup35. This subunit forms part of the inner ring within the membrane and interacts directly with Nup-Ndc1, considered to be an anchor for the NPC in the pore membrane. This region of the Nup is the RNA-recognition region.
Statistics
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PSSM-Id: 113924
View PSSM: pfam05172
Aligned: 8 rows
Threshold Bit Score: 100.935
Threshold Setting Gi: 2498160
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WWH_A        18 SEDHLDDTW-----VTVFGFPQASASYILLQFAQYGNILKHv-------------------------------------- 54
gi 115502433 192 EEADAADTW-----VTVFGFQPSQVSILLNLFSRHGEVVSHq-------------------------------------- 228
gi 78100748  163 GAPQDSNTS-----VIVFGFPPELTNQVIAEFSRFGTIISEnsltass-------------------------------- 205
gi 2497161   239 GSKEGASTNwddhaIIIFGYPETIANSIILHFANFGEILEDfrvikdfkklnskn------------------------m 294
gi 82069071  160 SDDQLDDTW-----VTVFGFPQASASYILLQFAQYGNIIKHv-------------------------------------- 196
gi 75274884  180 TGNLDEEEW-----VTVYGFSPGDTNLVLREFEKCGMVLKHv-------------------------------------- 216
gi 75027645  184 GNSRLSDFW-----VTIFGFPPGAGSMVLQHFTVCGTIVDVv-------------------------------------- 220
gi 2498160   257 KVHETSSKSsslsaIIVFGYPESISNELIEHFSHFGHIMEDfqvlrlgrginpntfrifhnhdtgcdendstvnksitlk 336
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
1WWH_A        55 ------------MSNTGNWMHIRYQSKLQARKALSKDGRIFGESIMIGVKPC--IDKNVME 101
gi 115502433 229 ------------TPSKGNFIHMRYSCVTHAQQAISRNGTLLDQDTFIGVVQC--TNKDVIN 275
gi 78100748  206 -----agftpskGPISGNWLQLTYAEPSSAAKAVLSNGMLINDSFMVGCIYSpaEAKEHVP 261
gi 2497161   295 skspsltaqkypIYTGDGWVKLTYKSELSKSRALQENGIIMNGTLIGCVSYSpaALKQLAS 355
gi 82069071  197 ------------MSNNGNWMHIQYQSKLQARKALSKDGRIFGESIMIGVKPC--IDKSVME 243
gi 75274884  217 -----------pGPRNANWMHILYQNRSDAHKALNKAGMMINGVVIVGVKPVdpIQKQALN 266
gi 75027645  221 -----------hAPQNGNWMYVRYSSRIESDKALNYNEKIIAGNVMVGVSRC--TDRSVID 268
gi 2498160   337 grnnesnnkkypIFTGESWVKLTYNSPSSALRALQENGTIFRGSLIGCIPYSknAVEQLAG 397
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