Conserved Protein Domain Family
Bombinin

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pfam05298: Bombinin 
Bombinin
This family consists of Bombinin and Maximin proteins from Bombina maxima (Chinese red belly toad). Two groups of antimicrobial peptides have been isolated from skin secretions of Bombina maxima. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin-like peptides (BLPs). Unlike BLPs, sequence variations in maximins occurred all through the molecules. In addition to the potent antimicrobial activity, cytotoxicity against tumor cells and spermicidal action of maximins, maximin 3 possessed a significant anti-HIV activity. Maximins 1 and 3 have been found to be toxic to mice. Peptides in the second group, termed maximins H1, H2, H3 and H4, are homologous with bombinin H peptides.
Statistics
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PSSM-Id: 114046
View PSSM: pfam05298
Aligned: 3 rows
Threshold Bit Score: 254.907
Threshold Setting Gi: 68052038
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68052038    1 MNFKYIVAVSFLIASGYARSEENDVQSLSQREVLEEETLREIRGIGGALLSAGKSALKGLAKGLAEHFANGKRTAKGHEV 80
gi 123905016   1 MNFKYIVAVSFLIASAYARSVKNDEQSLSQRDVLEEESLREIRGIGRKFLGGVKTTFRCGVKDFASKHLYGKRTAEEHEV 80
gi 68052268    1 MNFKYIVAVSFLIASAYARSEENDEQSLSQRDVLEEESLREIRGIGTKIIGGLKTAVKGALKELASTYVNGKRTAEDHEV 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68052038   81 MKRLEAVMRDLDSLDHPEEASERETRGFNQEEIANLFTKKEKRILGPVLSLVGSALGGLIK 141
gi 123905016  81 MKRLEAIMRDLDSLDHPEEASERETRGFNQDEIANLFTKKEKRILGPVLGLVGNALGGLIK 141
gi 68052268   81 MKRLEAVMRDLDSLDYPEEASERETRGFNQEEIANLFTKKEKRILGPVISTIGGVLGGLLK 141
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