Conserved Protein Domain Family
Med9

?
pfam07544: Med9 
RNA polymerase II transcription mediator complex subunit 9
This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator. Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter.
Statistics
?
PSSM-Id: 311480
View PSSM: pfam07544
Aligned: 60 rows
Threshold Bit Score: 40.2412
Threshold Setting Gi: 734680729
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121777776   73 TTGPTTTTTsnp----dpDAQl------LSVKELPSATDGLKHKLQRARAAVRTLGDVRRAVAQQEAEMRALEGRRAAQA 142
gi 122069500   36 EILPVIYEIirs----ieKDPvdnaakqKESQDCSQKVLELQKRLDSARITIRQLPGIDYSKEEQLRRLESLRKQLALKQ 111
gi 74803271     7 EILPVVYDIirs----veKDPidntakqKESAECSHKVTELQKTLEAARSTIRKLHGIEYSKEEQLRRLESLRKQLALKQ 82
gi 158514036   58 EILPIIYDIvrc----veKDPlenavklRESQDCNHKIFELQKRFESAREQIRQLPGIDFNKEEQQQRLELLRNQLKLKQ 133
gi 241747899   10 EILHLIYDVirs----ieKDShdp-nqkRDSYDSAVKIQELRGKLQLCRDLIHKLPGVDYTGEEQLRRVEALRRQLARKR 84
gi 242016589   24 EFLPLIYEIikrdpahdsSQKp------RDSQDTSAKILELEKKLIQSRERVNQLPGIEHSQEEQLKQVENLRKQILLKK 97
gi 1008451082  23 EILPIIYEIirs----veKDHhdntakaRESQDCSQKVLELQKRLDQARAEIRLLPGIEYSKEQQLDHLEALKTQLKLKQ 98
gi 752890998   25 EILPLIYEIirs----veKDPhdttqkaKESQDTSHKILELQKKLDSARSQIKRLPGIEYSKEEQLQKLETLRKQLRLKR 100
gi 327285820   92 SFLPLVHDVikc----mdKDS----------QDVHQMLNELRTKFVEMRKLIKSMQGIGMSPEQQQVQLQNLREQVKTKS 157
gi 557010872   36 SFLPLVHDIikc----mdKDS----------QDVHQELNELKNKFQEMRKVVSTMPGIDASPEHQQQQLQNLREQVRTKN 101
                          90
                  ....*....|
gi 121777776  143 RALARAQADG 152
gi 122069500  112 QLIKKYKNVQ 121
gi 74803271    83 QLIKKYKNVQ 92
gi 158514036  134 QLIRKYKDTE 143
gi 241747899   85 ELLVKYKSMC 94
gi 242016589   98 QLLNKYRNMC 107
gi 1008451082  99 ELLRKYRYMY 108
gi 752890998  101 ELLLKYRNMC 110
gi 327285820  158 ELLQKYKSLC 167
gi 557010872  102 ELLQKYKSLC 111
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap