5SVA


Conserved Protein Domain Family
Med9

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pfam07544: Med9 
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RNA polymerase II transcription mediator complex subunit 9
This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator. Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter.
Statistics
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PSSM-Id: 336734
View PSSM: pfam07544
Aligned: 61 rows
Threshold Bit Score: 43.3235
Threshold Setting Gi: 1059636046
Created: 20-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5SVA_V         64 EFIPHIFYSlhqirKDPnNLSNQLETLTGSIRHRLKLCKSLISENEDtkdlLSKSPSEWQDIIHQREQELQIKRDVLDDL 143
gi 631236642   62 TPLPSSAPAgspggSGTlN-LKDVPTATDSIKHKLQKARAQIRQLPD----MNRSIAAQEAEIVELLTRMAQQREVLGRL 136
gi 549043524   23 DLLPDLYTLlqrvyNDd-LDAKDIGTESNALRLKISKARTLLANLPD----IQKTRQEQREEMDELVERIKKQRQMLKEI 97
gi 953374985  109 SVRPS-------------LDVKTLPTETSSVRIRIQKARTVVEGLPD----VHRSVDDQQREISELEDSVRRLRSVISDF 171
gi 1059636046 109 NATPTRSTAidttaVAF-LDPKVLLSEASGVKIRIQKAKAALEGLPD----MQRGVEEQEEEIAELEESIERLQEVIGEF 183
gi 525583762  115 SGLPA-------------LNVKDLPTATSSVRIRIQKARAVVETLPD----VSRTVEEQQAEIAELEDRIAHLHAVISDF 177
gi 242785751  141 SSLPP-------------LEAKDLFTAASAIRIRIQKARAVVDNLPD----VDRTTEEQEDEIEELQERIAALKGVIADF 203
gi 212543129  129 SNLPP-------------LEAKDLLTAASAIRIRIQKARAVVQGLSD----VERTTEEQDDEIEELQERIASLRGVVADF 191
gi 358368294  128 NSSPA-------------LDIKDLPTEVSSIKIRIQKAQAVVENLPD----VDRSVADQEEEIEELEDRIAKLKSVIADF 190
gi 1070327498  53 TTEPAPGTTghnasGPT-LSFKDVPGATDGLKHKLQRARAQVRELPD----MDRSIAEQNDEIRDLENRIEKQRALLQRL 127

                  ...
5SVA_V        144 YRK 146
gi 631236642  137 KDv 139
gi 549043524   98 GEL 100
gi 953374985  172 GNR 174
gi 1059636046 184 GRR 186
gi 525583762  178 GHR 180
gi 242785751  204 GRR 206
gi 212543129  192 GRR 194
gi 358368294  191 GQM 193
gi 1070327498 128 RDE 130
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