Conserved Protein Domain Family
RSD-2

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pfam07547: RSD-2 
RSD-2 N-terminal domain
This domain is found in three copies in the N-terminus of the C. elegans RSD-2 protein. RSD-2 (RNAi spreading defective) is involved in systemic RNAi. Mutations in the rsd-2 gene do not effect somatic genes but only germline expressed genes.
Statistics
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PSSM-Id: 311483
View PSSM: pfam07547
Aligned: 14 rows
Threshold Bit Score: 100.107
Threshold Setting Gi: 308450103
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75018789    96 FSSVPHHLTFNRKVAYADWYGLVDSSGI---EIKFAGVFGVMIAVNDL--------------DYELTGQHLFK-VVQRPW 157
gi 74960278    96 FSSDPSHLTYDRNIGYADWYGPVNCSQFk-aKNTKVAFFKYLIAVNDL--------------DYKNTGECLMK-AVQLVG 159
gi 75028332   227 CSSIETHITYPQSVAFADTFGKVNVAAE---SMERGVTYRVELAINII--------------DSEANNVPLFK-ISDIGE 288
gi 75028332   499 FSSNPKHKSYNKEVGVSDRYGFVEIPRIt-gDFEFGTVYSTQITMV----------------QYGDPLKACFKaVAPLKR 561
gi 341878897  210 FSSDPRHRTFDRKLAFADWYGLVDCSDVv-gLSQKCDAYKTFIVVKDM--------------DYVRNQTQLFK-VAVIKG 273
gi 341901800  549 FSNNNLHATYTKNVAFSNQFGHVEISKAd-eSLDHLVLYETFITLK----------------QCEDTALPVFEaISTLQN 611
gi 308461033   90 FSSNENHLTFDRQFGYADWYGFVDCSEVp--TDPSCSAFKTEITVNDS--------------ECKDNK--IFK-VVHLKV 150
gi 308450103   92 FSFLDTHPTYSKKKVYAGGFGHVEIEDHlseKMDRGIVYKVELSLNVL--------------EIKDNQKPVFK-VTKVYE 156
gi 308450103  394 FSSNQKHGSYNKTVAFSDSYGLVRIPESn-aSLKHMAVYNTLIQLLVLfnlniqsdkvrfrcQNEDKLKPIFIsVGPLKQ 472
gi 268552407  127 FSVESNHPTYSKKKAYAGVFGHVEVDENvalRMERNQVYKAELTFNNSt-------------ELSQKSTYGFK-VWSICG 192
                          90       100
                  ....*....|....*....|
gi 75018789   158 KLKSTADtSEFWQKLLQFEE 177
gi 74960278   160 VIDNRDA-AEVRLKMMEFER 178
gi 75028332   289 KLTGEEN-EAFLRKLNDFEE 307
gi 75028332   562 QFIDDLD--HYLQVMGKYED 579
gi 341878897  274 KLQKTSS-VELMQRMKDFEE 292
gi 341901800  612 KSDQSQI-EDMIKYMEEYEg 630
gi 308461033  151 KIDPRYYrEEYDLLMKKMee 170
gi 308450103  157 LLESEDG-EAFLNELYEFDE 175
gi 308450103  473 D-ENDPN-ARFIESMYNYED 490
gi 268552407  193 DASPEES-EAFMTSLYLYED 211
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