Conserved Protein Domain Family
FIVAR

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pfam07554: FIVAR 
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Uncharacterized Sugar-binding Domain
This domain is found in a wide variety of contexts, but mostly occurring in cell wall associated proteins. A lack of conserved catalytic residues suggests that it is a binding domain. From context, possible substrates are hyaluronate or fibronectin (personal obs: C Yeats). This is further evidenced by. Possibly the exact substrate is N-acetyl glucosamine. Finding it in the same protein as pfam05089 further supports this proposal. It is found in the C-terminal part of Bacillus sp. gellan lyase, which is removed during maturation. Some of the proteins it is found in are involved in methicillin resistance. The name FIVAR derives from Found In Various Architectures.
Statistics
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PSSM-Id: 311488
View PSSM: pfam07554
Aligned: 206 rows
Threshold Bit Score: 31.4837
Threshold Setting Gi: 81753613
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
4KJM_A       11 I-NDKSGTLASQNF-----LDADEQKRNAYNQAVSAAETILNKQTgpnTAKTAVEQA 61
gi 81420952 140 VsQKSATVSSLGLSnp-qySAILKKVNASYQAAEKILSASLDPISgsaPTPKSIAQA 195
gi 81420718 179 LnKKEAIVMS--LNqe-kySAILSEINAASSTAEEIVKQTLNPVNgnlPVVATLNAE 232
gi 81420717 171 LaKKETAVMT--LKdp-kySAILDQINGVSSKGEELVQHTLDPVSgivPAANTITEE 224
gi 75425854 162 LsQKNATVL---LNqp-kySAILNKINSIYAQGEEVVIRTLDPVSgaiPTAASITKV 214
gi 75474200 147 LsKQDETLAP--FAep-qfERIKNHLTALYTAGTAVAKMKLQSADgtaLDAKKVTDA 200
gi 81420720 168 VgNESATLAK--VEda-kfARIKENLVTLYNAGKMLTAKPLEGIDgavLDVDQVTQA 221
gi 81420870 170 IsNEETTLAV--YTqe-qfSGIKMHLTALYNAGKALTNRTLETVEgvvLDTQAVVDA 223
gi 75478228 156 LsNETATLAP--YAda-qyAGIKMHLSGLYDAGKAITTKTLEPVEgdpLTASAVMMA 209
gi 75478258 171 LeGENTTLAA--FNdsanyGGIKTHLLSLYNQAKTITTSTLLNDAgqsPNKDNVVKI 225
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