2XPK


Conserved Protein Domain Family
NAGidase

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pfam07555: NAGidase 
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beta-N-acetylglucosaminidase
This family has previously been described as a hyaluronidase. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity.
Statistics
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PSSM-Id: 336738
View PSSM: pfam07555
Aligned: 90 rows
Threshold Bit Score: 314.107
Threshold Setting Gi: 505046850
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XPK_A        152 RGIVEGFYGTPWTHQDRLDQIKFYGENKLNTYIYAPKDDPYHREKWREPYPES-----------EM-----------QR- 208
gi 81767118   200 RGFIEGFYGVPWSHEDRMNLMKDTSEYKMNTYIYAPKDDPYHRLSWKELYPEQ-----------EA-----------KQ- 256
gi 524058331  176 RGIVEGFYGHPYSVDNRISLFEFCKRFKMNVFIYGPKSDPYHLGNWRDNYPTS-----------LT-----------EQq 233
gi 514045423  170 RGLVEGFYGHPWSMESRLNILDHMMRYKMNYYVYGPKADPYHAGNWRVNYPETvtddqrklgqiTT-----------SD- 237
gi 524035044  179 RGLVEGYYGYPYTVAVKKDIMKFMARYKLNTYLYGAKSDPYHSGYYLDPYPTT-----------IT-----------EQq 236
gi 524283017  175 RGIIEGFYGKPYSSSVRKDLLRFMMRYKMNCYVYGPKSDPYHSGKWGEPYPTE-----------LTesqktsgfvcqQD- 242
gi 524479781  207 RGYIEGFYGA-WNFDERENLMEFAKDYKMNSYVYAPKGDAYHTSKWDQLYPDE-----------TI-----------KE- 262
gi 550275301  176 RGIVEGFYGYPYSVENRLSLLEYCKRYKMNLFVYGPKADPYHLGYWRRDYPTS-----------LTq----------AEq 234
gi 524069698  174 RGIVEGFYGHPYSTESRLNLLDYCKRYKMNMFVYGPKADPYHAGKWREDYPTT-----------ITd----------QEr 232
gi 644097654  158 RGAIEGFYGNPYSVDAHCSLFEFFKRFKMNVFIYAPKMDPYHLGYWTEEYPTE-----------ITe----------EQr 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XPK_A        209 ----------MQELINASAENKVDFVFGISP-----GIdirf-------dgdaG----EEDFNHLITKAESLYDMGVRSF 262
gi 81767118   257 ----------IAELAKAGAENNFNFCWTIHP-----GAtl-----------qfT----DEDFDALINKFEQLYSLGVRQF 306
gi 524058331  234 kffglitqddLRRMVEAAKNCNVNFIWAAHP-----GLqqgi--------sfsNttemNKGIDALMTKFEHLHTLGVRGF 300
gi 514045423  238 ----------IQQLATHAAACKVDFVWAVHP-----TLgsy----------yiS----LYWVDDIMTKFQQLYSLGVRHF 288
gi 524035044  237 ekngwltqdmFKELTSTAHATKVSFIWAIHP-----GLnt------------kT----DQDVTDVMNKFKLMYDLGVRQF 295
gi 524283017  243 ----------LKDFTSVAADTKVSVVWAIHP-----GNai-----------mnS----ATVVDDVMKKFGSMYDLGFRQF 292
gi 524479781  263 ----------FEKLVKKAEETKVDFVWSIHL-----GNffksfs---sisdakY----ETQYQKLMAKLEQLYKIGVRKF 320
gi 550275301  235 eqgm-itqddLRTIAAKAQACNVNFVWAAHP-----AMqdgisf----ssesaM----DPGIEAIMNKFDHLYGLGVRGF 300
gi 524069698  233 hmgl-itqddLRELASKAKACNVAFIWSIHPaleggGInf-----------snL----DPGVEAIMEKFDHLHKLGIRHF 296
gi 644097654  217 rmgw-itqddVRRMAETARACNVHFVWAAHP-----GLapggqvsmdfsntstV----DAGVELLMEKYHHMYDLGVRAF 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XPK_A        263 AIYWDDIqd----kSAAKHAQVLNRFNEEFVKAKG--------Dv--------KPLITCPTEYDTGAmvsngqPR----- 317
gi 81767118   307 GVLFDDTdd---wrNGQKQAEWINKIDTEFVKAKG--------Dv--------APMIVISARYNSAWgp---nMD----- 359
gi 524058331  301 GVFIDDMsy---tpSGNMQAHLANEVQIRLRNTYN--------Ntsdt-eehvSPLFFVPTAYALNY------GA----- 357
gi 514045423  289 GVSVDDMs-----gHPTNQAQLPDKVQQAIDEKWN--------TadaaeadcvGNVLFVPTCYALNY------GA----- 344
gi 524035044  296 GVFTDDAggydnpdNFPLYTQFFTNLQNQIDATWNtpgaapadTv--------KPLHYVPHVYNLTW------TSqdnrq 361
gi 524283017  293 AIFADDVnvpgdeaTMKKTADNVGAIQHAIEDKWNiagadpadTv--------KALRFTPQIYCRAF------AG----- 353
gi 524479781  321 DILNDDfg----ggNNDMVVTVLNRLNEDLKKKGC------------------QPITYCPQGYNKAWs-----GN----- 368
gi 550275301  301 GVFIDDIty---tpSGNMQAYLADQVQKKLKEKYN--------TvsatkdemvCPLFFVPTAYALNY------GG----- 358
gi 524069698  297 GVSIDDMs-----gHPYNQSDLADKAQVKLYEKFN--------KtgvseedkvGPLLFVPTQYALNY-------G----- 351
gi 644097654  287 SVCIDDMdr---npSAQMQAHLPDQTQKRLKEEFP--------Sqaed--ekiAPLFYVPATYALMYs-----GA----- 343
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XPK_A        318 A-----YTRIFAeTVDPSIEVMWTGPGVVtNEIPLSDAQ--LISGIYDRNMAVWWNYPVTDY--FKGKLAL--------- 379
gi 81767118   360 R-----YFKPFMqTLHDDIQVMWTGHATM-SNVSKEVFEwpKVQTGVDKDVAVWWNYPVNDY--CDSRILM--------- 422
gi 524058331  358 S-----STLYDLkNVDSEVVIAFTGYDCF-SNIRPSSIT--DMSNRVGRNPVMWWNNPVNDD--HDDRIYM--------- 418
gi 514045423  345 T-----YSLTPIqEISSKVEVAFTGYDCF-SNVRASSFG--SMAEYIGRDPIFWWNNPVNDD--HDTWLYM--------- 405
gi 524035044  362 A-----YFKALs-EIPEKIVFYTTGYGVWt-VPNNNDLN--TMKNEFGRDVAWWWNYPCNDNgrSDSQIFP--------- 423
gi 524283017  354 PdsqfnSFFQAMsSLPANVTVYYTGGGVW-SVPNNNDLN--TLQTQFGRQAIWWWNYPCNDNgtGPSEIYPldmksnfvd 430
gi 524479781  369 G-----AELTALkNLNDDIHIYWTGDDVn-SPITQETVN--FLKEKTNHDPDFWLNYPVNEH--AKSGIYL--------- 429
gi 550275301  359 S-----YSLNSLkSVDSDVVIAFTGYDCF-SNIRGSSCA--DMAGRVGRNPVMWWNNPVNDD--HDERIYMrgvtah-wt 427
gi 524069698  352 T-----STLSSFkNIHKDVLVAFTGYDCF-SNIRGSACD--RMADLIGRNPIMWWNNPVNDD--YDEFLYMhgltar-wi 420
gi 644097654  344 S-----SYLSQMaTVDKDVVIGFTGYAVC-GDLDKKDCD--AMAGYIGRNPLFWWNATVNDN--NDDRLYMreltahyal 413
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XPK_A        380 ----GPMH------------GL-----DKGLNQyVDFFTVNPMEHAELSKISIHTAADYSWNMDNY--DYDKAWNRAIDM 436
gi 81767118   423 ----APLH------------NL-----NQDLDN-VSGFFSNPMNQAEASKVALYSIADYTWNTDAF--DYMKSWETSIEK 478
gi 524058331  419 ----RKMT------------THwtiedPQGPINsLHGLVMNPMNQAQASKIALFGGADYGWNPSAF--DVEQNWEDVFER 480
gi 514045423  406 ----HGLT------------ARwt-ieQTGAVDhMRGFLLNPMNQGQVSKICNFSAADYSWNPDAY--NEQSSWEQALKS 466
gi 524035044  424 ----SDMYsnfidmtqvndnSR-----MPTSLEhCAGVLSNPMQQGEISKIALFSVADYAWNNDGF--DNMKSWEAAIPA 492
gi 524283017  431 mpnvGGGS------------I------ASELTAsNQGILCNPMEQGNASKTAIFSAGDYCWNNKGF--DNMKSWEASFKG 490
gi 524479781  430 ----GDIT------------YY-----ARDNVTgLAGFHSNPSRFAYSNEVGLYQLASLVWNNNKYseHANEIWESAFNY 488
gi 550275301  428 iedsEPIP------------S-------------LRGLMLNPMGQAQASKVALFGGADYAWNPARF--EKVSNWEASIRS 480
gi 524069698  421 iedkTPIS------------S-------------LQGLVLNPMNQGQVSKIALFSSADYAWNPAKF--DESASWEASLSS 473
gi 644097654  414 vpetGGIS------------T-------------LGGVILNPEKQAQAAKVGLFGLADYCWNPDRF--DVSQNWYDCFDY 466
                         410
                  ....*....|....*...
2XPK_A        437 LYg----D--LAEDMKVF 448
gi 81767118   479 FVp----E--VKEEFMRF 490
gi 524058331  481 LApn-dsQ--TATALKCF 495
gi 514045423  467 IVkt--dE--NVKALKDF 480
gi 524035044  493 IIs---eD--YAPAFRTL 505
gi 524283017  491 VLp---gNesAQKAYRFL 505
gi 524479781  489 Lq----pE--VKDSYLTI 500
gi 550275301  481 LVkd-deE--LRNAMRTF 495
gi 524069698  474 IVae--pE--LTEALKTF 487
gi 644097654  467 LAeagdtE--TAEQIRLF 482
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