Conserved Protein Domain Family
Peptidase_M26_C

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pfam07580: Peptidase_M26_C 
M26 IgA1-specific Metallo-endopeptidase C-terminal region
These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated with pfam00746, they may be attached to the cell wall.
Statistics
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PSSM-Id: 311508
View PSSM: pfam07580
Aligned: 7 rows
Threshold Bit Score: 967.297
Threshold Setting Gi: 81667566
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81667566   130 NISDATISDQQ-PVQTEKKVDAD---LVKSVTDSLKQVKYDAfdGDPKQVLRnwn-------hiQLTSSSLVDSFNEVYN 198
gi 62512118  1136 QVKEYNVDDLG-VVYTPNMVDKNrdsLITKVKEKLSSVALDS--AEVKSITN------------NPASLYLEESFAEVRE 1200
gi 62511886  1203 NLAEYNLGNTG-LLYTPNQFLYDrdsIVKEVLPELQKLDYQS--DAIRKTLGisp-------evKLTELYLEDQFSKTKQ 1272
gi 500813801 1839 AIAEYSVNGLG-LLYTPEAFLSDysrVLNQVLPELNLVVLDS--PAMRTVLGvna-------dtSLDDLYLDTAFDQVKT 1908
gi 530819121 1273 QVKEYSVAELGeVVYTPNMVDKDrsdLISAIVEKLSPVELQS--DPIYTHLGrtgp----nkvnAIKNLYLEESFQEVKD 1346
gi 765400066 1151 HVVEYTISGTD-LIYTPESFLNDrsaLINDLVSSLSTVVLDS--DAMKAVINypttldantqtgTAKDFYFGESYNQVMT 1227
gi 500811973 1252 ALPEYQIAELG-TVYTPNHSTAVkedLLTQLTESLKSFELYS--DEVYRSVGlpndn---drvnKVKRLFLDESLAEVKA 1325
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81667566   199 QLPTLVPQLLEHTDN-IDTANQ--------RVSDNAGAIMVGMSYINRWYNVSYGDKQLLPVMMFDPKAFG-S-NLDSID 267
gi 62512118  1201 TLDKLVKSLLENEDHqLNSDEVaeka-llkKVEDNKAKIILALTYLNRYYGIDYDGLNFKHLMMFKPDFYG-K-TPSILD 1277
gi 62511886  1273 NLGDSLKKLLSADAG-LASDNSvtrgylvdKIKNNKEALLLGLTYLERWYNFNYGQVNVKDLVMYHPDFFG-KgNTSPLD 1350
gi 500813801 1909 KLSEELRKVLAMDKS-INTEGNvvadyvaqKITANKEAFLLGLTYLNRWYNINYDNINVKDLSAYKFDFFGnN-NVSTLD 1986
gi 530819121 1347 NLTHFVKQLVENQDHqLNTDEAakra-likKIDDNKAAVLLGLSYLNRYYGVKFDDVHLKQLMLFKPDFYG-K-NVDVLD 1423
gi 765400066 1228 NLESNVRKILVAS---LNGQGQasedyikeKIINNKEAFVLGLTYLNRWYDINFGEMNTKDLTIFEPDFFG-NdAASALD 1303
gi 500811973 1326 NLQDMLGKLLANEWTrFHADNPavnealkaKIEENKTSIMLGLTYLNRYYDLKFGDYNLKELVLFKPDFYG-E-KVPLLD 1403
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81667566   268 WLSKIGdWSTDELAPSNTVTAFNNKLAPlLNTQSDLVTFLGDLRKKWTPDLSDEEWFRSNTG--VHIVEIPS-------- 337
gi 62512118  1278 FLIRIG-SAEKNLKGDRSLEAYREVIGG-TIGKGELNGLLGYNMRLFTKYTDLNDWFIHAAKn-VYVSEPETttedfkdk 1354
gi 62511886  1351 TLIELGkSGFNNLLAKNNVDTYGISLAS-QHGATDLFSTLEHYRKVFLPNTSNNDWFKSETK--AYIVEEKStieevktk 1427
gi 500813801 1987 TIISLGqSGFNNLKAKNNHMAYDSSLSE-ATGKRGLFNYLEGYRQLFLPYKTNNEWLKTNTK--AYIVEAKSdvaearql 2063
gi 530819121 1424 RLIEIG-SKEDYIKGTRTHDAFREVVAK-STLSGNLNDFLKYNMELFTSDTDLNDWFIKATKdnVYIVEPKTttpefadk 1501
gi 765400066 1304 MILAIGnGGYDVLRAHNNVTTFASIIGK-QNNQTKLFDMLEDYRQLFLPEMTNNEWFKQTTK--AYVVEGKSlipevaak 1380
gi 500811973 1404 RLIRIGrSTENQLKGADNVNMFARQLKA-ESKSNDLVAYLDYNRRLLTDFADMDSWFKDATRgfIQFEERQSeveeiksa 1482
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81667566   338 KEApdl----nlnIYHRLSTn------kDLQEYILPLLNVKNDDMYVVSALGMMIFGSYEPYIdvkyhkdpVVYQEKVQA 407
gi 62512118  1355 RHR----------IYDGLNNd-------VHGRMILPLLNLKKAHIFVISTYNTIAFSSFEKYG--------KNTEEERNA 1409
gi 62511886  1428 QGLagtk--ysigVYDRITSat-----wKYRNMVLPLLTLPERSVFVISTMSSLGFGAYDRYRss----dhKAGKALNDF 1496
gi 500813801 2064 QDAaegkskysvgVYDKITAdn-----wEHKGMLLPLLTMTEKGVYAISNMSTVSMGAYDRYRldgn-grvRTDAELAEY 2137
gi 530819121 1502 KHRa----------YEGLNNd-------VHGKMILPLLNLKDAHMFLISTYNTMAYSSFEKYG--------KNTEAERTA 1556
gi 765400066 1381 QETtdtyskynvgAYSKIVNdtvsnptwKYNHMLLPLLTLPQENIFIITNMNTIAIGSYEHYVd------dYSTVENRDK 1454
gi 500811973 1483 KYR----------VFDNLNSe-------YFSNYILPLLTLKNTRLAILSNYSTMAFVNRDKRR-----------SWSDER 1534
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81667566   408 VHKELTRLSTAWRDHFDFWYRMANEAGKKRLSNAn----IQIWDSYnai-dsSkkGG----RRWLNKRDTDIPAVAEFF- 477
gi 62512118  1410 YKAEIDRVAKAQQRYLDFWSRLALPKVRNQLLKSqnsvpTPVWDNQ------VyvGLgganRMGYGDGGRVVTPVRELF- 1482
gi 62511886  1497 VEENARETAKRQRDHYDYWYRILDEQSREKLYRT-----ILLYDAYkfg-ddTtsGK----ATAEAKFDSSNPAMKNFF- 1565
gi 500813801 2138 VEDRVRKTAEYQRDHYDFWYKILSPESKDKLFRS-----VLVYDGFslv-dkD--GK----RYWAPANDKKSLAMQEFF- 2204
gi 530819121 1557 FKAEIDKVAKGQQNYLDFWSRLATDKVRNQLLKSnnmvpTPVLDNQnyk-giSt------dRYGHTDSGKDVAPIRELY- 1628
gi 765400066 1455 VRQMVDLAAERQRDNADFWYKILDETNRDKLFRS-----VLNNEGYvmygkdGtkSY----RNLTADVD----AIQDFY- 1520
gi 500811973 1535 FNARIKEVATQHRNHVDTWYKLLSDDIKSRMVKQn---vTAVWDGF------DveGRgwidVNGNDNKGNPYAPSREFFn 1605
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81667566   478 ---GPLGKMYEAAg--LSADAVG---------N---------AVRYYVAQVVNNFGGIgILSHEMTHNFDNSIYLDGFQH 534
gi 62512118  1483 ---GPTDRWHQIN---WNMGAMA---------KiyerpwkddQVYFMVTNMMEPFGIS-AFTHETTHVNDRMAYYGGDWH 1546
gi 62511886  1566 ---GPVGNKVVHNq--HGAYATG---------D---------GVYYMSYRMLDKDGAI-TYTHEMTHDSDQDIYLGGYGR 1621
gi 500813801 2205 ---GPAGKWYPSKg--YNAYATG---------S---------VTHFDAARLLEDYGNS-VYTHEMTHNSDGGIYFEGYGR 2260
gi 530819121 1629 ---GPTDRYHATD---WRMGAVAriygnpykdD---------SVFFMVTDMISDFGVS-AFTHETTHVNDRMVYLGGWRH 1692
gi 765400066 1521 ---GPINKWYREHpsiKTAFADG---------S---------ETYYITYDMLTDYGTA-LYTHEMVHNQDGDIYLKGYGR 1578
gi 500811973 1606 lvgGRAGGWYKSNg--YGAHAAG---------Si--------RVNFEAFDLLTEYGVS-VFTHELTHVNDSYIYLGGHGR 1665
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81667566   535 RPGTGVETYATGLLESPWDRT----FANYGLNTALTFYADNN----RTTNKSP-SRFQTRKDLQDYMHGVFDVTYLLDYA 605
gi 62512118  1547 REGTDLEAFAQGMLQTPDKSTtngeYGALGINMAYERKNDGE----QLYNYDP-EKLDSREKIDSYMKNYNESMMMLDYL 1621
gi 62511886  1622 RNGLGPEFFAKGLLQAPDQPS----DATITINSILKHSKSDStegsRLQVLDPtERFQNAADLQNYVHNMFDLIYMMEYL 1697
gi 500813801 2261 REGLGAELYARGLLQSTPSAD----EATITLNTLFKVDKDSKt---RLHTYNFkERVQNAEDLQHYVHGMFDMIYTLDYL 2333
gi 530819121 1693 REGTDIEAFAQGMLQTPSVSNpngeYKALGLNMAYERPNDGN----QWYNTNP-NNLQSRDEIDRYMKGYNDTLMLLDYL 1767
gi 765400066 1579 RIGQGMEVYAQGLLQNVFNVT----EMNLGFNAVYN-SDDAN----RVHVGDPvARFNSEADFNEYYHNQFDVLYLLDYL 1649
gi 500811973 1666 RQGIGPEGYAQGLLQSPVPGQp--gWGALGLNMAFERPNDGS----LIFNSSP-SLFKNRADIDHYMKGYNDTLMLLDYL 1738
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81667566   606 EAQAMVgKSAKD-KQLMYSQISY------------DPAKKADVVSGPISTEi-ADKLMTIDDFIDNNIIASRGY------ 665
gi 62512118  1622 EASAVIrQNLSD-NSKWFKKMDKewrtnadrnrliGEPHQWDKLRDLTEEEk-KLPIDSIDKLVENNFVTLHGMpkngry 1699
gi 62511886  1698 EGQSIVnKLSVYqKMAALRKIENkyvkd---padgNEVYATNVVKELTEAE--ARNLNSFESLIDHNILSAREY------ 1766
gi 500813801 2334 EGTSML-KQNDDaKLQWFRKMENyyvt----dkygKETHAGNQTRSFTAEEi--KQLKTFNSLIENDVITRRENk----- 2401
gi 530819121 1768 EGEAVLdKHSKDlNNAWFKKVDKqyrg-----antK--NQFDKVRPLNDEEk-AIALNTVDELITNNFMTNRGPgng-vy 1838
gi 765400066 1650 EGTSIL-AQSDAdKKAWLRKIENyyvq-----nngVDTHAGNSARALTDAEv-A-SLKSFNDLIDQSIIVQRQYvnnptn 1721
gi 500811973 1739 EGQAVVdKGNEVa-AKWFKKVEPkvv---------daRTQYDVVRELTAEEkaAMSVSSVEDLVDQGLLSNRAVdnr-ty 1807
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81667566   666 QAGSYGtNSYQTISMYAPDYAAvQSSTSVSGGITFKKTAFELLAAKGWSNGFISYITNKYAKDAKND------------K 733
gi 62512118  1700 RTEGFD-SSYQPVNMMAGVFGG-NTSKSTVGSISFKHNAFRMWGYYGYENGFIPYVSNKLKGAANKEn-----------K 1766
gi 62511886  1767 QSGDYErNGYYTIKLFAPIYSAlSSEKGTPGDLMGRRIAYELLAAKGFKDGMVPYISNQYEEDAKQQgqtin--lygkeR 1844
gi 500813801 2402 DSGKYGrNGYLSLSLFSPIYSAlSNPNGAPGDVMFRRTAYELLAAKGYHEGFVPYVSGKYSQEAFDEgmktwdgwsgrdV 2481
gi 530819121 1839 NPSDFG-SAYVTVPMMTGIYGG-NTSEGAPGAMSFKHNTFRIWGYYGYEKGFLGYASNKYKQESKQAg-----------L 1905
gi 765400066 1722 TSKKWDrNSYVSVPMFAANFSAlSNSNGSPGDIMFRRMAFELIAAKGYTDGFVPYASGQLSDLAMEKgsiiydtwnkknT 1801
gi 500811973 1808 NPADYD-SSYIAIDFMTGIYGGgQNNTGAPGALMFKHNTFRIWGYYGYEKGFVSYASNKHRKTANEQg-----------V 1875
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81667566   734 KSLSDTYALAKIFNGEYDNdYAIFKKAMFKERIDK--RQDFKPITITld------kkSIQLNSWDDLQNLMQTTVDQELA 805
gi 62512118  1767 GLLGDDFIIKKVSKNQFQN-LEEWKKHWYHEVYDKa-QKGFVEIEVD----------GVKISTYAQLQSLFEEAVSKDLA 1834
gi 62511886  1845 GLVTDELVLKKVFDGKYKT-WAEFKTAMYQERVDQ--FGNLKQVTFKdptkpwpsygTKTINNVDELQALMDQAVLKDAE 1921
gi 500813801 2482 GLVTDQKVLENVFKGEYDS-WASFKKAMYQERIGQ--LTKLKPITIEyelknpsstnKVTIRSYEEMQKLMDAAVAEDVR 2558
gi 530819121 1906 ATLGDDFVIQKISDGRFST-LEDWKKAYFNEVVTSa-KNGIQAIDID----------GKTYNSYEDLKRAFAEAVDKDKG 1973
gi 765400066 1802 GLITDDHVLEYVFQGQYTS-WAEFKKAMFTERFEKaaAGQLKPFTMQyelgvadstkEVTITSFEQLQNLMKEAMEADIQ 1880
gi 500811973 1876 TGLSDNFIIKQISEGEFET-MEAFKKAYFRQVAEKaqTSGIKPVTVN----------GKVYSTYEELKAGFAEAVDKDLK 1944
                         810       820       830
                  ....*....|....*....|....*....|....*...
gi 81667566   806 VRAQGKKS----SLINDLKAAILTAELKQTDDFRSSIF 839
gi 62512118  1835 GMDDKNIKnh-yQYTENLKWKIYKQLLKNTDGFSSDLF 1871
gi 62511886  1922 GPRWSNYDpeidSAVHKLKRAIFKAYLDQTNDFRSSIF 1959
gi 500813801 2559 NITNATSRve-aSWVNLLKKKIYNAYLRETDDFRQSIF 2595
gi 530819121 1974 TLSNGSVKf---DNTVALKEKIFKKLLQQTDSFKTSIF 2008
gi 765400066 1881 ANSL-NLNt---SRVHALKVKVYQALMNSTNDFRTSIF 1914
gi 500811973 1945 KSRVDE------RATKDFKYAVFTQLLKNTNSFmdens 1976
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