Conserved Protein Domain Family
Kelch_2

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pfam07646: Kelch_2 
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Kelch motif
The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Drosophila kel is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.
Statistics
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PSSM-Id: 311537
View PSSM: pfam07646
Aligned: 43 rows
Threshold Bit Score: 28.4773
Threshold Setting Gi: 74725575
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
4UNM_A        257 RWYPTLTT-LG-------DGKILSVSGLddi-------gqlVPGKNEVYDPKTKAWTYTDKV 303
gi 75265953   264 PRAYHTMT-CI-------GARHLLIGGFdg---------klTFGDLWWLVPEDDPIAKRSSV 308
gi 18277872   241 NVCDGIES-VP-------YHKVFSFGGRkgm--------mqYLNTVEVMDCGTQMWSTPPVD 286
gi 122064804  250 SSIGHSAV-VS-------GDYMFVYGGWpfihnelhletplRVERLQILDIRHETWKTVQLE 303
gi 74725575   114 PRSGFSVAmAP-------NHQTLFFGGVcdeeee-eslsgeFFNDLYFYDATRNRWFEGQLK 167
gi 74750172    30 ARVGHSCS-YLppvgnakRGKVFIVGGAnp---------nrSFSDVHTMDLGKHQWDLDTCK 81
gi 75169801   122 NVRSSSLV-AV-------GSDIYNICGSink--------asSSSSVSILDCQSHTWRE--AP 165
gi 229889802  127 PPSELTRI-TN-------GSNIYIVRVFtn---------gaFSSRFLFMDCRSHTLHEVPRM 171
gi 75099548   119 YQVLVPSV-IV-------GSETYIVGGYdd---------alSSSVWFYKNGKIHTLSKSPSM 163
gi 75098682   255 KRPRLLRG-NG-------DSKLLMIGGLkstfs---lnpacSTILILRLDLESLEWEEAGRM 305
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