1TBR,1BMO


Conserved Protein Domain Family
Kazal_2

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pfam07648: Kazal_2 
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Kazal-type serine protease inhibitor domain
Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.
Statistics
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PSSM-Id: 336754
View PSSM: pfam07648
Aligned: 42 rows
Threshold Bit Score: 35.9078
Threshold Setting Gi: 124851
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
1TBR_R         55 DVCQECDgD--EYK--P-VCGSDD---ITYDNN-CRLECASISSSPGVe-----------LKHEGPC 101
gi 1708383     43 SHLFFCT-R--EMD--P-ICGTNG---KSYANP-CIFCSEKLGRNEKFd-----------FGHWGHC 88
gi 146345396  788 SPEEDCShH--SED----LCVFDTdsnDYFTSPaCKFLAEKCLNNQQLh-----------FLHIGSC 837
gi 75019262   306 STCITCPkD--EKKi-P-ICDNRN---MTHPTL-CSFIQYNCEARNNEdee-------rvLVHIKSC 357
gi 74871006   293 KCNFQCPkA--SLS----ICASNGkcvVNFPGQ-CELSQWNCFNTKNVf----------hQVHDAEC 342
gi 74871005   255 NCDELCTkF--EYS--P-ICAHNGiciHEFANQ-CVMNTFNCKHRDLSfrav-----dedVCRLGVC 310
gi 75019262   114 DCNHNCTnT--EFD--P-VCDTNG---SVYRNL-CVFQMRRCELQLESqri-------qlAEDRKFC 164
gi 13959711    98 QDPTSCPaP--VGEfeK-VCSNDN---KTFDSS-CHFFATKCTLEGTKkgh------klhLDYIGPC 151
gi 464320      75 ECISKCPeL--DGDpmDkVCANNN---QTFTSL-CDLYRERCLCKRKSkecskafnakvhLEYLGEC 135
1BMO_A         26 QDPTSCPaPigEFE--K-VCSNDN---KTFDSS-CHFFATKCTLEGTKkgh------klhLDYIGPC 79
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