2EYX,4Z88,2DBK,3KFV,3SHW,2GTJ


Conserved Protein Domain Family
SH3_2

?
pfam07653: SH3_2 
Click on image for an interactive view with Cn3D
Variant SH3 domain
SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.
Statistics
?
PSSM-Id: 336757
View PSSM: pfam07653
Aligned: 36 rows
Threshold Bit Score: 35.5178
Threshold Setting Gi: 81482133
Created: 25-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2EYX_A         8 YARVIQKRVPnaYDKTA-------LALEVGELVKVT---------------------KINV---------SGqWEG-EC- 48
gi 166977689 418 HGIANEDIVS--RNPTE-------LSCKRGDVLVILk--------------------QAEN---------NY-LEC-QR- 456
gi 81879804  657 FGKLLKTVVR--QNKSHy-----lLEYKKGDVVALLs--------------------EERIrlkgqlwtkEW-YIG-YY- 706
gi 81797019    2 RARLLCDYRA--AYANP-------IRFHAGQQVAIg---------------------VRDE---------EWpAFAwVNt 42
gi 81837344    2 KYIVIKSHVS--NYPNP-------IRLEEGDVVKMIesy---------------agpENWE---------NW-MFChEEk 47
gi 81444177    6 KYIVVCKWVE--SYKNP-------IILKKDEKVVVNlai----------------keTDPEw-------vNW-VWC-IAg 51
gi 81482133   35 VGKVTGNYVN--VRTEGslsgsviTQVSKDEVVTVL---------------------EKQG---------DW-YRI-RLs 80
gi 74732360  310 VHRVTRSFVG--NREIGq------ITLKKDQ-IVVQk-------------------gDEAG---------GY-VKV-YT- 349
gi 795311375 473 iFRCVRTFIG--CKEQGq------ITLKENQ-ICVSs-------------------eEEQD---------GF-IRV-LS- 512
gi 10442652  308 lIVEHEQLGN--ESTGE-------LHLTVGDILKCIdsnpqvcdtrsdthhqyslssSSSR---------KW-IKC-ENw 367
                         90
                 ....*....|...
2EYX_A        49 -NGKRGHFPFTHV 60
gi 166977689 457 -GEGTGRVHPSQM 468
gi 81879804  707 -QGKVGLVHTKNV 718
gi 81797019   43 gEGHAGWAPAAWL 55
gi 81837344   48 -YNRKGWVPEQII 59
gi 81444177   52 -NGMTGWVPIQIL 63
gi 81482133   81 -DGREGWIYGEYL 92
gi 74732360  350 -GRKVGLFPTDFL 361
gi 795311375 513 -GKKKGLIPLDVL 524
gi 10442652  368 -FGVIGLAKISNV 379
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap