Conserved Protein Domain Family
SH3_2

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pfam07653: SH3_2 
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Variant SH3 domain
SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.
Statistics
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PSSM-Id: 311542
View PSSM: pfam07653
Aligned: 32 rows
Threshold Bit Score: 37.8395
Threshold Setting Gi: 81482133
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LH5_A         5 YIRTHFEYEKESPYG-------LSFNKGEVFRVv-----DTLYNgk------lGS-WLA-IRigKNHKeverGIIPNKNR 64
gi 81797019    2 RARLLCDYRAAYANP-------IRFHAGQQVAI------GVRDE---------EWpAFAwVNtgEGHA----GWAPAAWL 55
gi 81837344    2 KYIVIKSHVSNYPNP-------IRLEEGDVVKMiesyagPENWE---------NW-MFChEEk-YNRK----GWVPEQII 59
gi 81444177    6 KYIVVCKWVESYKNP-------IILKKDEKVVVnla-ikETDPEw-------vNW-VWC-IAg-NGMT----GWVPIQIL 63
gi 81482133   35 VGKVTGNYVNVRTEGslsgsviTQVSKDEVVTVl------EKQG---------DW-YRI-RLs-DGRE----GWIYGEYL 92
gi 122119015  35 PGQLTKNFTATVADE-------ISVTRGTTVKAi------YRDD---------QW-IYV-EVs-DGRK----GFVPQTYC 85
gi 74732360  310 VHRVTRSFVGNREIGq------ITLKKDQ-IVVq----kGDEAG---------GY-VKV-YT--GRKV----GLFPTDFL 361
gi 166977689 418 HGIANEDIVSRNPTE-------LSCKRGDVLVIl-----KQAEN---------NY-LEC-QR--GEGT----GRVHPSQM 468
gi 81879804  657 FGKLLKTVVRQNKSHy-----lLEYKKGDVVALl-----SEERIrlkgqlwtkEW-YIG-YY--QGKV----GLVHTKNV 718
gi 795311375 473 iFRCVRTFIGCKEQGq------ITLKENQ-ICVs----sEEEQD---------GF-IRV-LS--GKKK----GLIPLDVL 524

                 ...
3LH5_A        65 AEQ 67
gi 81797019   56 RPL 58
gi 81837344   60 RKD 62
gi 81444177   64 NVC 66
gi 81482133   93 SVR 95
gi 122119015  86 KLL 88
gi 74732360  362 EEI 364
gi 166977689 469 KIV 471
gi 81879804  719 LVV 721
gi 795311375 525 Eni 527
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