Conserved Protein Domain Family
Nucleos_tra2_C

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pfam07662: Nucleos_tra2_C 
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Na+ dependent nucleoside transporter C-terminus
This family consists of nucleoside transport proteins. Rat Slc28a2 is a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane. Rat Slc28a1 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.
Statistics
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PSSM-Id: 311549
View PSSM: pfam07662
Aligned: 394 rows
Threshold Bit Score: 110.523
Threshold Setting Gi: 187903103
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PD5_A        208 LVAASFMAAPGGLLFAKLMMPETekpqdnedit--------------ldggddkpanVIDAAAGGASAGLQLALNVGAML 273
gi 81666907   203 VIAALLLNMFSTIIILSLINPYTinpeqdlyi----------------pyfitknnnFFTIIGEYILIGFNIATTVAAML 266
gi 81598051   197 VCTAIVLNMLSTFFVLHIINPYDkdpslnydtl--------------hadyetgrqsFFEMLSEYLLDGFKIAVIVCAML 262
gi 122540268  193 VVTAVMLNIFSALIIASVINPYKsddtdveidnltkste---tktlngktgkpkkvaFFQMIGDSAMDGFKIAVVVAVML 269
gi 123564782  194 VVVAVFLNIFSALIISCIVNPYEpevedqktie---------------ahlstekepFFQVLGNYIVDGFQLALTVAAML 258
gi 122276955  194 VVVAVFLNILSALIISSIVNPYIpekedklve-----------------iskgnaepFFQVLGNYIVDGFQLAITVAAML 256
gi 332371269  139 VVPAVFLNIFSALMVSCIINPYNasnydtmpms---------------kneeknhesFFQVLGDYILDGFKLAVTVAAML 203
gi 503889924  194 VVTAVFLNILSALIVSCIINPYDvapeeelsmnt-------------neslnvskepFFQVLGNYIQDGFKLATTVAAML 260
gi 503539194  194 VVVAVFLNILSALIVSCIINPYDidandtlve-----------------iqeektgsFFQILGNYITDGFKLAITVGAML 256
gi 1032718738 194 VVVGVLMQLLSALAVSVIVNPYNdkeeiakgtqayqeregiegdqaeeaqgekekepFFSMLSDYMVTGWNTAVIVAVML 273
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PD5_A        274 IAFIGLIALINGMLGGIggwfgmpELKLEMLLGWLFAPLAFLIGVPwNEATVAGEFIGLKTVANEFVAYSQFAPYlteaa 353
gi 81666907   267 IGFIALITATNTIFKIIf------GISLQHILSYIFLPFTWTIGIPiAEILPVSKIMATKLITNEFVAMIDLQKIl---- 336
gi 81598051   263 VGFIALLNLVDGIFQEIl------GITFRQILGYIFYPIAWVLNIHgNEIFLSSQIMGTKIVTNEFVAMQELAKNs---- 332
gi 122540268  270 LAFISLMEAINIMFGSV-------GLNFKQLIGYVFAPIAFLMGIPwSEAVPAGSLMATKLITNEFVAMLDFKNVl---- 338
gi 123564782  259 IGFVSLVTFLNNTFGFFf------NVTFTDIIGWVFAPVAFVIGVPaDDIVKVGSLMATKLITNEFVAMGNLSQIa---- 328
gi 122276955  257 IGFVALVTFLNNSFLAVi------NISFTSLIGYIFAPIAFLMGVPtSDILKVGSLMATKLITNEFVAMGTLHGIa---- 326
gi 332371269  204 IGFVALVNFLNSIFVAIf------NISFTTILGYIFSPIAFLMGVPtKDSIKVGSLMATKLLTNEFVAMSSLHNMs---- 273
gi 503889924  261 IGFVALVTFLNSTFVAIf------NVEFTTVLGYIFSPIAFLMGVPsEDITQIGSLMATKILTNEFVALGELNQVa---- 330
gi 503539194  257 IGFIALVTFLNNSFLAIi------HVSFTTILGYIFSPIAWIMGVPaHDIIKVGSLMATKLLTNEFVAMGDLHNLt---- 326
gi 1032718738 274 IGFVALISMLNSLFEGLi------NISFTELVGYVFSPFAFLMGVPkEDMVQAGSVMAQKVLANEVVAMTSLSALe---- 343
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
4PD5_A        354 pvVLSEKTKAIISFALCGFANLSSIAILLGGLGSLaPKRRGDIARMGVKAVIAGTLSNLMAATIAGFF 421
gi 81666907   337 -hTLSTRSIGILSIFLVSFSNFTSIGIIIGTITKLnTTQGKIIAHYGLRLIYSSTLVNLLSATIASLI 403
gi 81598051   333 -qQLSEHTKAVVSVFLVSFANFSSIGIIVGAVQALnKEASIKVARFSLKILYGAVLVSILSACVVGFI 399
gi 122540268  339 -gDVSARTQGIISVYLVSFANFGTVGIIVGSIKGIsDKQGEKVASFAMRLLLGSTLASIISGSIIGLV 405
gi 123564782  329 -hSLSPKATAIISTYLVSFANFGTIGIISGSIKAIdKKQGAVVAKFTMKLLLGATMASMLTGTIVGMY 395
gi 122276955  327 -gTLSTKANAIISAYLVSFANFGTIGIITGSIKSIsAKQGSYVAKFSIRLLAGATLASILTGTIVGFY 393
gi 332371269  274 -sTLSLKANAIISAYLVSFANFSVVGIITGSIKSIsSKQGITVANFSMKLLLGATLASILTGTIVGLY 340
gi 503889924  331 -eALSPKGNAIISSYLISFANFSVVGIITGSIKSIsEKQGGFVAKFSMKLLLGATLASILTGTIVGVY 397
gi 503539194  327 --GLSTKSHAIISAYLVSFANFGTIGIITGSIKSIsEKQGSYVAKFSMKLLLGATLASVLTGTIVGFY 392
gi 1032718738 344 --GLSEKTAAIMGTYCMSFANFGTLGMVIGGVKAIdAHQGNVVAKYSLKIVLVSTLASMVTATIVGFL 409
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