Conserved Protein Domain Family
Gate

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pfam07670: Gate 
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Nucleoside recognition
This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins. In the FeoB proteins, which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'.
Statistics
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PSSM-Id: 311551
View PSSM: pfam07670
Aligned: 233 rows
Threshold Bit Score: 28.7609
Threshold Setting Gi: 81766407
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PB1_A      106 RVLPTLIFFSALISVLYYLGVMQWVIRILGGGLQKalGtSRAESMSAAANIFVGQT-E----APLV----VRPfVPKMTQ 176
gi 81745771 176 QLACIVIPLMIIMQLMRDRGWLDTMSNKMAPFMRLl-GiDKSASMTMVAGLTIGLAyGaglmIQAV--------KEDNVS 246
gi 81785631 176 QLALIVIPLMILVQVMKDLNWLQTFSKWMSPFTKVl-GiRENTSTTLASGLLFGLAfGagvmIQAI--------KEDGVK 246
gi 81637559 176 QLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLl-G----MNKNTSMTMVTGLTiGlaygAGVM----IKA-VEDDGV 245
gi 81443543 278 RIIPYLVAFLVGIAVFRTAGAMDFLVGGIGYVVDLc-GvDTSFVGALPTALMKSLSgs---gANGLmidtMKEmGPDSFV 353
gi 81461272 276 QLIPYLLAMLLAIGLLRASGALDYLLQLIAGGVSLf-GlDTRFVDAMPTALMKPFSgs---gARAMmletMAHhGVDSFA 351
gi 81424424 277 DLLPYLVAMLCAIGVLRASGALDFALDGMRWLAHAa-GwDTRFVDALPTALVKPFSgs---aARAMmletMSHfGVDSFP 352
gi 81539395 277 NLLPYLVAMLCAVGVLRASGALEVVLGGIRWAVEGl-GwDSRFVEALPTALVKPFSgs---aARAMlletMQThGVDSFP 352
gi 81733017 277 SLLPYLVAMLCAVGVLRASGALDFGLEGIRHVVQWl-GlDTRFVDALPTAMVKPFSgs---aARALlietMQTqGVDSFA 352
gi 81506563 283 GIVPYLVAVLVGIAVFRAAGCMEFLMQGLSAAFSHl-GiDTRFVPALPVGLMKTLSga---gARGLmvdvMTTyGVDSFQ 358
                        90       100
                ....*....|....*....|....*....
4PB1_A      177 S-ELFAVMCGGLASIAGGVLAG--YASMG 202
gi 81745771 247 KkDMSLALIFLVSCHAVVEDTL--VFIPL 273
gi 81785631 247 K-KDLYLVFIFLVA-CHAVIEDtlIFIPL 273
gi 81637559 246 S-KRDMTLAFIFLVACHAVVEDtlVFIPL 273
gi 81443543 354 G-RMSCVVRGASDT-TFYILAV--YFGSV 378
gi 81461272 352 G-RLAAIFQGSTET-TFYVLAV--YFGSV 376
gi 81424424 353 A-LLAAVMQGSTET-TFYVLAV--YFGSV 377
gi 81539395 353 A-LVAATVQGSTET-TFYVLAV--YFGSV 377
gi 81733017 353 A-LAAATIQGSTET-TFYVLAV--YFGAV 377
gi 81506563 359 G-KLAAIIQGSTET-TFYVLAV--YFGSV 383
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