Conserved Protein Domain Family
PA14

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pfam07691: PA14 
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PA14 domain
This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.
Statistics
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PSSM-Id: 311565
View PSSM: pfam07691
Aligned: 23 rows
Threshold Bit Score: 99.778
Threshold Setting Gi: 37538299
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4H2A_A         15 SSQGL-LGYYFSDLNFQAPMVVt-------SSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATS-ADN 85
gi 81445416   630 LNSGLkAVWHKFRGNLCAD-----------IDAAPVNGEYVVESVSIPEEVKGDIGLIITGYLEVPADGIYTFALL-SDD 697
gi 81712494   387 LEPGLdYRMYLGKFKKLPEFET--------MEVERTGQVDSLNLEEIQGDQRDDFALSINAMFRVPEEGLYRFQIT-SDD 457
gi 74844920   117 LRTASgNYIYDNDFFFPIDYEG--------FDTDPANRIYKDDESTNKTYHNYHFCFQFDNRFLF--KGNETFKFT-GDD 185
4LHN_A         78 DSYGn-WGCKGMG-----------------ACSNSQGIAYWSTDLFGFYTTPTNVTLEMTGYFLPPQTGSYTFKFAtVDD 139
gi 549648     121 DNTTLsSKTEKRE-----------------NDDCDQGAAYWSSDLFGFYTTPTNVTVEMTGYFLPPKTGTYTFGFAtVDD 183
gi 37538299   626 PKPGL--TIRTAYGDLYDVPDLqqvaswevGTVSSLEEIMHGKEKITSPEVLERRVVEATGYVLIPEDGVYEF----STE 699
gi 81657820   396 LRSGVlVETFEPVAPSPPLSSIaelr-ddeTFVANTPSTASDISSFSYSAAPGAKVSRIRGIVSPPVSGHYTFHLA-ASD 473
gi 74638721   398 GKHGYvAKFYLEPATSENRTLI--------DDYDLEDGVVRFYDYCNDKMKDGYFYIDIEGYLIPDEDAVYEFGIS-VFG 468
gi 589115013  397 GAPGMrWRVFNEPPGTPNRQHIde-----lFFTKTDMHLVDYY----HPKAADTWYADMEGTYTADEDCTYELGLV-VCG 466
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4H2A_A         86 HVTMWVDDQEVINKA--------------------------SNSNKIRLEKGRLYQIKIQYQRENPTEK---Gld--fKL 134
gi 81445416   698 GSTLKLDGELLGDNDgah---------------------spVEIIVQKALKAGLHPIEVRYFDCNGGVL---------QM 747
gi 81712494   458 GSRVFLHDKLFLDHDgnh---------------------ppMTVSRLVRAGAGLHPIRIDYFEGGGAQT---L-----TA 508
gi 74844920   186 DVWVFINKQLVVDLGgthpa-----------------asssVDLSTLGLTVGKVYPFNFFYCERHTSRS---TirietSL 245
4LHN_A        140 SAILSVGGATAFNCCaqqqppitstnftidgikpwggslppNIEGTVYMYAGYYYPMKVVYSNAVSWGT---L-----PI 211
gi 549648     184 SAILSVGGNVAFECCkqeqppitstdftingikpwnadaptDIKGSTYMYAGYYYPIKIVYSNAVSWGT---L-----PV 255
gi 37538299   700 NNEFWIDNVKLIDNVgev--------------------kkfSRRNSSRALQKGYHPIKTIWVGAIQGGW---P------T 750
gi 81657820   474 EAELWLSQGVTSDTSrliasvatpt------lmegftdanaGLSASVYLVAGQDYYVETLQVHDDPVAK---Nh---lSV 541
gi 74638721   469 TALLFIDDVLLIDNKtkqtptnh-----------tfefgtiEERNSIYLKKGRKYNVRVEYGSAATYTL---S------T 528
gi 589115013  467 TAKAYVDDQLVVDNAtkqvpgda-----------ffgsatrEETGRINLVKGNTYKFKIEFGSAPTYTLkgdTi----VP 531
                         170
                  ....*....|....*.
4H2A_A        135 YWTDSQNKKEVISSDN 150
gi 81445416   748 ELVNEKGEKEVLPKEW 763
gi 81712494   509 ALTRLDVAGDDDGDDS 524
gi 74844920   246 ELYCDKYDYCGVCNGD 261
4LHN_A        212 SVTLPDGTTVSDDFEG 227
gi 549648     256 SVVLPDGTEVNDDFEG 271
gi 37538299   751 YWNYSRVMIRLKGEEK 766
gi 81657820   542 AWTRPDQLASGPQLIG 557
gi 74638721   529 NLSPSTGGRYSIGCVK 544
gi 589115013  532 GHGSLRVGGCKVIDDq 547
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