Conserved Protein Domain Family
7TMR-DISM_7TM

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pfam07695: 7TMR-DISM_7TM 
7TM diverse intracellular signalling
This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).
Statistics
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PSSM-Id: 311567
View PSSM: pfam07695
Aligned: 176 rows
Threshold Bit Score: 50.7184
Threshold Setting Gi: 494026956
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81699397  129 IQY-INGIYFGILIA-MAVYNLFLLLTV-RDKSYFFYVFYILCFAIFLM-SQYGFAYEYLw----pEFS-WGARRMNPFL 199
gi 81465486  181 RAI-LFGLTLGFGIA-MGLYNFSLYMFF-RTRSYLYYFIMILFSTVYLA-SWDGLISPLFk----pNYGrYYLPFILVLF 252
gi 122988042 163 RHD-LQLISLAVTVA-LGCLFFSLWVMRrQEAAYGWFSLMSLAWWCVAL-NQVATTTWPF-------AStDAWERANTVA 232
gi 81700249  192 SVL-TLTILAGILLL-AATFFISLFIFYpKEKQSLYFGLLAANFSLRIC-CYDEFLLTTIi----pGISgEALFRIGYMT 264
gi 81568621  199 SRW-----MLAFLYLfVGFYHFLLYFKRpQEKYNLFFGLFSTFFSVYIH--LRSNAVYEL------NLDpLFQMKLEYMV 265
gi 122281057   9 SCY-----LVTTVLAyGTLHNLFLYYKNrKQIYLLHFAFLQISYGLYLL--CFTKTINVV------NAEeALVWERLENT 75
gi 81408149  232 FEY-WDLLLYGIYTI-FGIYHIYFYFIRrKDLYYLYFGLFSFFSSVYFF-SSSNLIFQKFvnp-npELDsSLFFRMQYSS 307
gi 81846258  202 INL-----CLNTIYVfFGFYHLLIYVKRrEDLYNLYFGIFSVFMALYSL-SRSNIAFEVI-------YDtTWITRIEYSS 268
gi 494289757 176 FDMmLLALVVGMLVL-PLFFDVSFFIVL-KERFVVTHAVMVASMIVYVL-FAGGLITVFA------DVPlRVMAVAGPLC 246
gi 494026956 210 WVL-YETLTMTTMFV-VGCAFLLFYATRrRGVFRMYFGLFALACALRTSvAGDGMPLTVIwpglpwAARiSLEYATSWAA 287
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81699397  200 AGLLE-FSILlFTRDF----LDTkntfptlhKYNHVLIILCAM--ASFSS----------------FFv---NLTQGALQ 253
gi 81465486  253 YTSAL-FLFL-FSMEF----LYPek----keRYVKIIIFLYVVvnLLLIPl--------------sIF----YPTHLNRI 304
gi 122988042 233 LLVYSvAYML-SMARFcerrLP---------RVEGGLWLLAAVgaAVMIWa--------------pTE----SLTMVRNV 284
gi 81700249  265 ISLGIiFAAL-FINNL----FSKik-----sRYWFIMLAPGILyiIINIFa--------------pMR----VSSALLQP 316
gi 81568621  266 IFNITsLFLL-FLNTFfqykIS---------FVSKLYQIFTLTltLLIPFs--------------nRS----VCLFLLKL 317
gi 122281057  76 VLPIFgMFLIlFVNSY----HRIfs-----kDFVYLYILLSVLlsIVILMdpnsyntkltsqkkfpLLgivvYETEQSSL 146
gi 81408149  308 LTLIFpSFYY-FLKDY----FSPkek---gsVIASFFVIFLIGlfFAFLTv--------------pFS----WVHIAFKI 361
gi 81846258  269 VSLLApLFLL-FMQDY----FYGrak---fsKVLFAILILNVViaLTTLLe--------------pFR----YTMTSLRL 322
gi 494289757 247 WAIGCgLSAM-FLVDF----LEKdaqs-sfmRRLTVATGVWTVfvPGFFAl--------------qLH----ATQPVDDL 302
gi 494026956 288 VGLGVlTVTRlYHQEdy-------------pPLSYGLLGLGGLaaLALGLg--------------pAR----WSMVTVTP 336
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81699397  254 VAILGLLTAISILASGIKAL--MSGFRPARYFM-IAFSALLLGGAFYALKTIG--AIPVS-FVTE-YSMQI---GSGLEV 323
gi 81465486  305 SYYLGLVNNLIIVYFCIVRI--RGGFKSAKNFL-IIHLVFPVAGILTNLSTFG--AISID-YLSL-HLLKL---AFISQS 374
gi 122988042 285 L-TLWAACVFFATCIVFLGFawRHGRTDHRILS-VCIAIFLVAAVHDLLSFLG--ILTDNaYYAA-LTSQV-------QM 352
gi 81700249  317 AQIYVLLFAAYNVIIVMKAA--SRKDASAILFL-TGFSIFLILGVRDV--LIAnrIIQGF------FLSHI---GVLVLL 382
gi 81568621  318 WQFSIFTFIVYSFFIMYKSL--VRKNPDAIRMI-FGFLVLMIAGVMDL--IGSmgLIDNL------ENYGIlkyGFFVFE 386
gi 122281057 147 VHYLYLSGILMSIWISFKVIlqFVHNLLSNLFLpIGLILFCANVFLd--------ILTAMdFVPLpYTSHF---SFLILM 215
gi 81408149  362 CQILAICFSVYILFFSIQTV--RKKKQDARKIL-VGICVCIVFSTW---------ELYGSvFENAkYHSTFfklVYLFFI 429
gi 81846258  323 WQISILPTLVYLLYFMSKAV--YLRKKDAILLA-TSMFTVVFIAVYd--------VIDSIfFQSGiRFTQF---AYFLFV 388
gi 494289757 303 LYFYTFIPAMVIITAAIAEAl-WRGSKSARFLA-FAWSPIILSSLERM--MRGlgVYAGPsQLDQtLYLAV---GL--EV 373
gi 494026956 337 LQAFAAFAIVWVLIVVVRAV--LARRFGSRGLL-AAMLAFLLALVHDI--ARArgLLPTPfELTQpAFVGV----VLIEA 407
                        250
                 ....*....|....
gi 81699397  324 TLLSLGLG--D--R 333
gi 81465486  375 VLFSVMLV--Q--R 384
gi 122988042 353 IAMALVLA-----W 361
gi 81700249  383 IPMAIVVL--R--N 392
gi 81568621  387 VGMVFILA-----N 395
gi 122281057 216 FSVDSVLTlnQsgN 229
gi 81408149  430 ISIASTLV-----L 438
gi 81846258  389 VALTTILA-----N 397
gi 494289757 374 IVISLAIA-----S 382
gi 494026956 408 AQLARSFA-----Q 416
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