Conserved Protein Domain Family
7TMR-HDED

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pfam07697: 7TMR-HDED 
7TM-HD extracellular
This entry represents the extracellular domain of the 7TM-HD (7TM Receptors with HD hydrolase).
Statistics
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PSSM-Id: 336770
View PSSM: pfam07697
Aligned: 219 rows
Threshold Bit Score: 76.982
Threshold Setting Gi: 502947498
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122481903  48 KLGDPSPQLVTAPYEKniEDLKKYYQDQEAAAEAVKPVYTQDEEYLTSISRDLSTAFTA---------------LEEA-- 110
gi 81626880   25 ELGSIAPRYIVSQVNFdfLDEEATVILKQDSIRDVGKIYRLSQNDIRRKRIEFENFLLY--------------------- 83
gi 123759882  57 KPGDISQVNVIAPRDAkvIDTTDLKEKKQDLKESFVQ--SIDKNKSSDLEKTVSKKINIlhtkkynnfgidfneFNi--- 131
gi 81574951   57 QPGALAPFNAIAPKDAlvQDSTALEQRRSTLVARSVVQ-VLDPDQTQALKLRLERQLSElqqvsesgsaarvgpVNl--- 132
gi 81577347   61 NPGLPAPFEARAPRDArvVDSEAQEQRRSQLVQSTFVQ-VIDQQETTRLKKRLERNLAElervarnsdagrigpVNl--- 136
gi 81664386   63 KPSDLATFDAIAPDNAqvIDSAALQQKRSDLIPRTSVQ-VIDTKASQKLKETLIDQLYEleqvarsndsdrlgpVNl--- 138
gi 504978690  49 KVGTFVTRDIRAPRTAetVDREATREAKERARQEVPQIYRVDNTARVRSVQHLEELLIVgd------------qIRDAvg 116
gi 147850157  35 RPGLPAPFEIRAPRDAsvVDSEALAQRRSQLGPRIQVQ-ITDQNATSKLESRLNRMLAEllnsrta-gemrltpIAv--- 109
gi 504920870  58 RPGMPAPFTARAPTDAtvIDSTDLEQRRSQMLPRSQIQ-VVDPQASEALVQQLELRLQRvrqtvad-dqprpdsLNl--- 132
gi 147848446  34 RPGLTAPFDAVAPKDArvVDSEALKQRRSSLVPSTLVQ-VIDNKQDQQLRMRLERYLGElervassddadrigpVNl--- 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122481903 111 ---------------------------------------------------------------------IASDEDKADVL 121
gi 81626880      --------------------------------------------------------------------------------
gi 123759882     --------------------------------------------------------------------------------
gi 81574951      --------------------------------------------------------------------------------
gi 81577347      --------------------------------------------------------------------------------
gi 81664386      --------------------------------------------------------------------------------
gi 504978690 117 pspyidtsllsygvqlylrecpepvwqdlqkrvetlqqqleqlqtadssianqnniygrvvtellrrrnLMSEAEYRDLI 196
gi 147850157     --------------------------------------------------------------------------------
gi 504920870     --------------------------------------------------------------------------------
gi 147848446     --------------------------------------------------------------------------------
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122481903 122 KKLRQVAPfn-------vlPQEALE-GLLDSSLDLLEEKEQKATEVILVNA-----RGketgahtpqdvpALRQ-KIKQd 187
gi 81626880   84 --------------------NQAWHkHTEN---GQFDELYQATEKIEQALVemrftDArt--------ldRMKSlGI--- 129
gi 123759882 132 -------------------TKPEKD-WILNVKDNEWEEWKEEIKNVSKKML-----SQgi--------inTLALdQLNEa 178
gi 81574951  133 -------------------NADEQV-WLEQRSDQDRFAWDNVVRQAANRML-----SQgl--------vsTLAVdQLREa 179
gi 81577347  137 -------------------NAEEQI-WLQARSQQERKRWDMAIRRASERML-----SQgl---------nNLALeQLQEa 182
gi 81664386  139 -------------------TKRERQ-WITSQSVQNRSKWREEIINASEKML-----SQgl--------ikTLAHdQLEKs 185
gi 504978690 197 NQIEQARGryktavialeaGPDLFQdYLLDLRDSEWDVDKQAALLALNNLM-----AEglipglp----pelrqyRISSr 267
gi 147850157 110 -------------------SPEDEA-FLLTQTPQELRKWQTTVEQAQQRML-----TQgv--------vsTLAEdQLQRa 156
gi 504920870 133 -------------------TEQERR-WLMGLTPPELMRWKVSLRRAQQRML-----SQgv--------vaSLSEgQLLTa 179
gi 147848446 110 -------------------SAAEED-WLEERLPDERLSWDMAVRRALERML-----SQgl--------vnNLAEeQLRQa 156
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122481903 188 ineasFP------DEFKAFLNEFVDAKiT--QPT--------------------------------LLE----------- 216
gi 81626880  130 ----------------------LTNQY-QiyTPNtlidqtvlpesiwekiqakdlplsqyeplvsaLTIeffkhshwhie 186
gi 123759882 179 ss-lqLIdlgekdSPNRTLGAKILSSS-FhqKSN--------------------------------LKV----------- 213
gi 81574951  180 ag-lqLQgdaidnPAARSLAGKLLVSS-LqgSSN--------------------------------LRT----------- 214
gi 81577347  183 aa-iqLAdlgeqnGPARSLSSKLLAST-YqgSSN--------------------------------LRT----------- 217
gi 81664386  186 ss-rqLSsla-geNPAKTLGSKLITNA-FhgKSN--------------------------------LRH----------- 219
gi 504978690 268 pn-lpIA------EYRRQIIIDLLDTV-L--IPN--------------------------------LEP----------- 294
gi 147850157 157 ak-lqLDql---pePGRSLGAKLITRS-LqgSTN--------------------------------LRT----------- 188
gi 504920870 180 ae-lqLQdl---spPARSLGSRLLAAS-LqgRTN--------------------------------LRS----------- 211
gi 147848446 157 ts-lqLEelgaadAPARTLGSKLLTTT-LqgASN--------------------------------LKT----------- 191
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 122481903 217 -DTEATEKLRQNARASVLMesQRYKANQKIVGPGEIVDEKIMQVLVGYGLVE 267
gi 81626880  187 eDIPAQRQLRKKIQSFVPDkyTHVNAGNRIIDQGEKVTSRHIAMLQSMksal 238
gi 123759882 214 -DKLKTNILIENLINQEGIntINVKEGSIISRKGKPITSQEFDILEHFNKVS 264
gi 81574951  215 -DPNLSKQLIEEQLTKQGIptIDVRKGDLITRKGEPISPQAYDVLDFFGKVK 265
gi 81577347  218 -DPALSQRLIEELITKQDIpiIEVRRGDLITSKGEPISPRAYAVLNHFGLVS 268
gi 81664386  220 -DPSRSQKLLEELITKQGIpkIEVKKGDLITRKGEVITQKRYDVLDYFGLIS 270
gi 504978690 295 -DYVATDQLAAKAAEEVEAkvITLQAGEVIVRAGQQITEKEFAFLDSLGLAQ 345
gi 147850157 189 -DNSLTQVLLNDLIQQNGVpkIEVKAGEVITVKGEVISQRAYDVLDAFGLIS 239
gi 504920870 212 -DSFLSQRRIEDLLTRQGLptIRVRKNDLITRQGEPISPQAFDVLEHFDLVN 262
gi 147848446 192 -DPQRSQRLIEKLITQQGIpvIEVNQGDLITQKGEPISSQAYDVLDFFGLVN 242
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