Conserved Protein Domain Family
7TMR-HDED

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pfam07697: 7TMR-HDED 
7TM-HD extracellular
This entry represents the extracellular domain of the 7TM-HD (7TM Receptors with HD hydrolase).
Statistics
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PSSM-Id: 311569
View PSSM: pfam07697
Aligned: 218 rows
Threshold Bit Score: 77.7402
Threshold Setting Gi: 502947498
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81482004   45 KAGDVAPQDIKAPKDV---IDVIATQKKIQEAVNAVNPKY-------DYNENIAK-ESYLKLADFFNK--------LRE- 104
gi 493986961  54 KVGSISNRKIVAPFDFfvlKTEKELKAEQDSVLKGVPYYF-------VYDDSLTL-QNKRLLRNLLPFlvnai------- 118
gi 505237847  48 KEGQVSEVEIIAPFDFpvlKSPQELAAEKEQVLSQVDKPY-------EISEEPLF-EAISNLDNIYAVlcs--------- 110
gi 504669312  43 vgsiwiqdDLIASKTFeilKDAETYKKERQAAAARVLPVF-------IRDDNVAR-ASLDSLKRYNKF--------LQQr 106
gi 502606639  67 vgevwqhnDLVAPFDFalyKDPEQLEQERRQVILQTPP-YfrevpdaMRRMEANRdTVRMQLEAIFEA------------ 133
gi 503398600  48 kgmvwlhdDLVAPYNFsirKTAAEIKQDRESIAKSILPVY-------RIDDKIFE-SQVSQYQADFEAkwlg-------- 111
gi 503422404  36 QIGEIAKETVYAPFQV---ENEVATNRLRTLAAAGVEPVY-------KKDSTVQE-KAIGNIEKLFEAvtaiqtsdVAT- 103
gi 503372453  56 QIGELSDEDVYATENFt-yIDEIRTQALIAEKQRAILPLF-------SFSLRSTI-LSVQRVESFIAL------------ 114
gi 504035068  56 KSGELANEDVFATSSFq-yLDEEKTKGMREQEYAKILPNF-------SFSLKGTT-TSMERVRSFKQAw----------- 115
gi 504616121  61 aLGDVATGDLKAQMDLr-iADDNETERLKKAAFERERPAF-------DRDFEAFE-KSLKQLQTEFTWiart-------- 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81482004  105 -----------VRkSSESEEQKLQDFKNITPINl-------------------------------------------EDK 130
gi 493986961 119 ----------pqyeKMDNKEEYLKNLSEELNLVfdvk-------------------------------------ispSNL 151
gi 505237847 111 ------------iePTDDWEKIASDLKRAGYSF--------------------------------------------SPE 134
gi 504669312 107 lskeeffkyipLS---NSSAEIFYRFKRNPASFgn-----------------------------------------lQIR 142
gi 502606639 134 -----------------YASYRRNLLRGRQDAArddslryaelrrnarvkltpeqwrllaedyraaineagqvvrrgGQE 196
gi 503398600 112 --------------------------------------------------------------------------aklPEG 117
gi 503422404 104 ----------------TLGKTEVEVLSGRSPIGl-------------------------------------------YNE 124
gi 503372453 115 -----------IR---SPLPEQIQVFQDKETLQddgnvi---------------------------------qrilsLGA 147
gi 504035068 116 -------------eNPETAVTDLSLFFAENRLTdqanvr---------------------------------grfssLSP 149
gi 504616121 124 ----------ateaAQMSVAERRELILGRMPFLads---------------------------------------lyRSE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81482004  131 DIA-FLLKIDDSTLIKMETVILSAEKAIM-----AR-------------------------------------------- 160
gi 493986961 152 AVAfDILK-VEENVRAIKK-VLNIAEKLMvqgilNKetttftrprvvvikngv--------------eepldferridfa 215
gi 505237847 135 ALEfTLRS---SLRDKIYESLRRELGTLYnqgiyESleedsiliwqndn----------------------pekralsdf 189
gi 504669312 143 SFRnLL-NLSEELIKR-------IYQRglidqsyqdikrdsitvrqgk---------------yeriypktfffdissvs 199
gi 502606639 197 PLYvRALE-----------EAWSFGVQVLqlgllDVprdsvltdeivvrnever------------tervlsvdrvfgld 253
gi 503398600 118 DIKeKTFE-----------FGFSVLKSLY-----DKgiiglnqsyqknqsdgsylitllknnvrsevstatlltpssals 181
gi 503422404 125 QYE-TLLSASTDELTYVKDACISIASDIF-----TTgi------------------------------------------ 156
gi 503372453 148 LDQqFFLQ-----------ALEETSDEILkkglfSQavvsairgqgy---------------------------eeyllq 189
gi 504035068 150 DVRsQMLE-----------ALSAAMETILqkglfSSdsinrlidqgy---------------------------gyytii 191
gi 504616121 155 DIDgLFRE---KQIQQIESRALTLAEKAF-----QEngfltqtletkilaeviekg--------aqirtinaprdapdvv 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81482004  161 ----QITE-DALQSalndaksVVessdipVDAKPVAV---E------------ILSSV-I--VPNMIYNAYETNLAKKEA 217
gi 493986961 216 nfqkTLENeFLKHFsvnhtlvLEy----------------------------lFVRSL----KPNLIFEREFTEKAKEEA 263
gi 505237847 190 lpreKAKEiLIDKF---------------PEAKTFVS---E------------FTEQY-L--KPNLLVNEEKLNELNQSS 236
gi 504669312 200 efieSYLRaNAGNN---------------DELVSALT---E------------YILYF-L--KPNINFSYDDTQMAIQIA 246
gi 502606639 254 eaygAAREyFLQQF---------------NNRPELASialA------------FFRAI-L--VPSYVYLRAETLHAWEQQ 303
gi 503398600 182 qaseRIVSnKS------------------VRTDILIS----------------VIKDR-I--TPNVILDERFSEALEKQA 224
gi 503422404 157 --ssEESNkTVEVRsaidntdLS------VTMKKIAQ---D------------IINDV-L--APNVVEDEVATNEQKKIK 210
gi 503372453 190 ntvsMEKNhNKEAHlfsevltKE------NLANGLEAwmeGyrsvnatfqpylLSDALsWllQENIVYEEVETLNQRQHA 263
gi 504035068 192 ntisMAKAeKADKIpfqeavtKE------KIEDALHSwvsPyiqlypgfqpdlLFDTLkLlaEVNVVYDEASTLLLREEA 265
gi 504616121 219 wsaeQLQTkETAVRlilrnnqLKdaalspGTMRVILT----------------RIRQL-QreIPSLVYNPQYTLLRRNQA 281
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 81482004  218 EEKvQPVM--YKKGQNIVVSGEIVTPEQIEVLKSLGLLK 254
gi 493986961 264 LANiSRTKdmVYENELIVDKNIRIDPATYQKLYSLEmai 302
gi 505237847 237 LQTvQPSEgmVLKNEVIVRKNSRVTEEEVRKLESLQeay 275
gi 504669312 247 MDRvPKVIgiVNENERIVAKHDRITPEIKQKIDSYRIak 285
gi 502606639 304 QARiSPTYglVKAGEVIVQRGQVVTEEIKRKLTSLERaq 342
gi 503398600 225 VENvSVTRgmVQKGEVIVENGNVVNENVYQKLESLRqsy 263
gi 503422404 211 SDKvDPVY--VLAQEKIVEKGSKVTEEIYQLLEKVGYLD 247
gi 503372453 264 AESvQEIVvlVERGEKIISKDTVINAQQLALLERmsnet 302
gi 504035068 266 EKRiSPIYvnVKRGQKIVTKDTVITEEQLDLLSKmnnsy 304
gi 504616121 282 AEKiTPVYksVKRGSTLLRAGDLITEENLRLLEQVrenh 320
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