3TFF,1XBN,2KII


Conserved Protein Domain Family
HNOB

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pfam07700: HNOB 
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Haem-NO-binding
The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine. It is a haem protein sensor (SONO) that displays femtomolar affinity for nitrous oxide, NO. It is predicted to function as a haem-dependent sensor for gaseous ligands and to transduce diverse downstream signals in both bacteria and animals.
Statistics
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PSSM-Id: 336772
View PSSM: pfam07700
Aligned: 176 rows
Threshold Bit Score: 106.792
Threshold Setting Gi: 495731427
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3TFF_A          2 YGLVNKAIQDMISKHHGEDTWEAIKQKAGl-eDiDFFVGMEAYSDDVTYHLVGAASEVLGKPAEELWIAFGEYWVTYTSe 80
gi 81461810     2 KGIIFNVLEDMVVAQCGMSVWNELLEKHAp-kD-RVYVSAKSYAESELFSIVQDVAQRLNMPIQDVVKAFGQFLFNGLA- 78
gi 123089948    2 KGAVLIALNDMVEEVFSMAVWDQVLAKVKpdsE-GIYISAESYDDAEVVGLVVALSELTGVPVNELVRSFGTYLFHQLN- 79
gi 123090013    2 KGAVFVTLKTMIEESHGPTAWAALVDKVApecE-GVYDANENYPDADAIAYIGAVAELLNSSASAVTEIFGRYLFDALN- 79
gi 81377766     2 KGIVFTSLNDMIIEQFGIETWDQLVSSLDlpsG-GSYTAGGTYSDTEFQQLIKAIAKRTNQHASVFLEAFGEYMFPILS- 79
gi 1054525003   2 HGIILQTLQSFVVDTYGEDAWLAIQDEADi-eE-KVYVPVTVYPDGDVYEIARTAGELTDQSPRTILTQYGRWVVPALLe 79
gi 941258122    2 HGVILAHLRHFVTDRYGPSVWDDVNHRAGl-tD-CLHVPIQLYPDSHLEDLVAALQSVTGLHRDDLLEEFGAWVIPPLI- 78
gi 503644736    2 HGIVLKGLKDFVTEEYGADVWTDLHEAAGf-rT-RLYVPVTEYPDEIVLELVDAATDLTGLEEPTLLAAFGRFLVPHLL- 78
2KII_A          2 KGIIFNVLEDMVVAQCGMSVWNELLEKHAp-kD-RVYVSAKSYAESELFSIVQDVAQRLNMPIQDVVKAFGQFLFNGLAs 79
gi 495731427    2 HGIVHKTLKEYVVERTDDGTWDTIVEQSGf-eP-KLYLPVSHYDDREIDAILETLSTMATQDRRAIERDFGTTLAPKLL- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3TFF_A         81 EGYGELL-AsaGd-SLPEFMENLDN-LH-A-R---VG-LsFPQ-LRPPAFECQHtSSKSMELHYQSTRc-GLAPMVLGLL 149
gi 81461810    79 SRHTDVV-D--KfdDFTSLVMGIHDvIHlE-V---NK-L-YHE-PSLPHINGQLlPNNQIALRYSSPR--RLCFCAEGLL 146
gi 123089948   80 SKFPIFC-D--LhtNIFDLLSSIHGvIHkE-V---DK-L-YSN-ASLPTINCTKlSDSHLQMRYYSPR--KLCVLAEGLI 147
gi 123090013   80 SMSPQYA-A--AspTLFGFLQSIEPlIHrE-IrnsNK-----S-SSLPVIVVKVtDEQHLLMRYNSPR--KLCFLAEGLI 147
gi 81377766    80 SKCAIFL-K--KdmTLKEFLKSIDGtIHvE-V---EK-L-YPD-ETLPTISYEEpAANQLVMVYRSHR--RLCHFAMGLI 147
gi 1054525003  80 T-YDLHI-DddWe-GL-ELIANIQQ-FH-T-S---LRtRdMTT-LTTPRIRSERlDEDRVRITYDSDRk--LCDVARGAI 146
gi 941258122   79 NMYRAMIpRe---wDAVAFLLNVEErIH-QrV---IR-LkNPE-ATPPRIDVRElEPRVLQVEYRSHRd--LSLLALGCV 147
gi 503644736   79 STYGVHV-DreWt-GL-ELIANVETyIH-E-A---LR-AkQSGeFTPPELRTRRvDDRRVALAYESDR--GLCALARGLL 147
2KII_A         80 RHTDVVD-Kf---dDFTSLVMGIHDvIHlE-V---NK-L-YHE-PSLPHINGQLlPNNQIALRYSSPRr--LCFCAEGLL 146
gi 495731427   79 STFSAHI-Krd--wDLPELLAGLED-VY-D-D---IE-AaTED-TALPELSCTSeAD-HAIVSYDTHRdqQYCGLAHGIL 146
                         170
                  ....*....|....*
3TFF_A        150 HGLGKRFQTKVEVTQ 164
gi 81461810   147 FGAAQHFQQKIQISH 161
gi 123089948  148 IGAAEHYKADVSVSQ 162
gi 123090013  148 RGAAKHYGETVELSH 162
gi 81377766   148 QGAAQHFKKKITIKQ 162
gi 1054525003 147 RGVADRFDEDLVAEE 161
gi 941258122  148 HGVAAFYGEKVEIle 162
gi 503644736  148 EGIADYYDEPLHIEQ 162
2KII_A        147 FGAAQHFQQKIQISH 161
gi 495731427  147 EGVVAAFGADAAVTE 161
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