Conserved Protein Domain Family
Pkinase_Tyr

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pfam07714: Pkinase_Tyr 
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Protein tyrosine kinase
Statistics
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PSSM-Id: 311583
View PSSM: pfam07714
Aligned: 123 rows
Threshold Bit Score: 211.204
Threshold Setting Gi: 73920239
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_I        21 VKIEEVIGAGEFGEVYKGRLK----------LPGKREIYVAIKTLkaGYSEKq--RRDFLSEASIMGQF-DHPNIIRLEG 87
gi 74996665 1057 VAIVEKVGAGSFANVFLGIWN---------------GYKVAIKILknESISN---DEKFIKEVSSLIKS-HHPNVVTFMG 1117
gi 73920239   16 FEIYEEIAQGVNAKVFRAKEL-------------DNDRIVALKIQ--HYDEEh--QVSIEEEYRTLRDYcDHPNLPEFYG 78
4L01_B        27 LVQGEHLGRGTRTHIYSGTLMdykd---degTSEEKKIKVILKVLdpSHRDI---SLAFFEAASMMRQV-SHKHIVYLYG 99
gi 21263757  580 IVQGEHLGRGTRTNIYAGILKpksdd-eddlGGYSQEVKVVLKVL--GSGHRd-iSLAFFETASMMRQI-SHKHTALLYG 654
4FVR_A        10 LIFNESLGQGTFTKIFKGVRRev------gdYGQLHETEVLLKVL--DKAHRn-ySESFFEAASMMSKL-SHKHLVLNYG 79
gi 2499671   517 LEWHENLGHGSFTKIFHGHRRev-------vDGETHDTEVLLKVM--DSRHQn-cMESFLEAASLMSQV-SYPHLVLLHG 585
gi 34761802  368 lQTTEGLGQGTFTQVFRGIRRev------gdYGEVHKMEVVMKILdkSHRNY---TESFFESASMMSQL-SHKHLLLNYG 437
gi 47222167  586 iEQEEHLGRGTRTNIYSGTLRvkseededagYSSFQEVKVVLKLLsyGHRDI---SLAFFETASMMRQV-SHKHIVLLYG 661
gi 1171246   716 LHLLERIGQGRFGTVHRALWH----------------GDVAVKLLneDYLQDehmLESFRNEVANFKKT-RHENLVLFMG 778
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_I        88 VVT-Ksr-----pVMIITEFMENG---ALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS-- 156
gi 74996665 1118 ACId--------pPCIFTEYLQGG---SLYDVLHIQKIKLNPLMMYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDE-- 1184
gi 73920239   79 VYK-LskpngpdeIWFVMEYCAGGtavDMVNKLLKLDRRMREEHIAYIIRETCRAAIELNRNHVLHRDIRGDNILLTK-- 155
4L01_B       100 VCF-Rdv-----eNIMVEEFVEGG---PLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAReg 170
gi 21263757  655 VCVrHqe------nIMVEEFVQYG---PLDLFMRRQTTPLSTAWKFQVAKQLASALSYLEDKKMVHGYVCSKNILVARdg 725
4FVR_A        80 VCFcGde------nILVQEFVKFG---SLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIRee 150
gi 2499671   586 VCM-Agd------sIMVQEFVYLG---AIDTYLRKRGHLVPASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAReg 655
gi 34761802  438 ICV-Cad-----eHIMVQEYVRFG---SLDTYLKRNRNTINITWKLEVAKQLAWALHHLEEKSLTHGNVCARNVLVTRee 508
gi 47222167  662 VCV-Hhq-----eNIMVEEFVQLG---PLDVFMRRQQNPLSIPWKFQVAKQLASALSYLEDKKLVHGFVCAKNILLARdg 732
gi 1171246   779 ACM-Npp-----yLAIVTALCKGN---TLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHARDIIHKDLRTKNIFIE--- 846
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_I       157 ------NL-VCKVSDFGLSRYLqddtsDPTYTSSLGGKIPVRWT---APEAIAYRK----------FTSASDVWSYGIVM 216
gi 74996665 1185 ------FK-NIKIADFGLATTL-------SDDMTLSGITNPRWR---SPELTKGLV----------YNEKVDVYSFGLVV 1237
gi 73920239  156 ------NG-RVKLCDFGLSRQV-----DSTLGKRGTCIGSPCWM---APEVVSAMEsre-----pdITVRADVWALGITT 215
4L01_B       171 id-secGP-FIKLSDPGIPITV---------LSRQECIERIPWI---APECVEDSKn---------LSVAADKWSFGTTL 227
gi 21263757  726 l--dgeGGpFIKLSDPGIPITV---------LSREECVDRIPWI---APECVKDTAn---------LTIAADKWSFGTTL 782
4FVR_A       151 dr-ktgNPpFIKLSDPGISITV---------LPKDILQERIPWV---PPECIENPKn---------LNLATDKWSFGTTL 208
gi 2499671   656 v---dgNPpFIKLSDPGVSPTV---------LSLEMLTDRIPWV---APECLQEAGt---------LNLEADKWGFGATT 711
gi 34761802  509 drktgtPP-FIKLSDPGISITV---------QPREILLERIPWV---PPECVKDSRn---------LSLAADKWSFGTTL 566
gi 47222167  733 mgtdegGP-FIKLSDPGIPITV-------LTRE--ECVHRIPWI---APECVKNVSa---------LSVAADKWGFGTTL 790
gi 1171246   847 ------NG-KVIITDFGLFSST------KLLYCDMGLGVPQNWLcylAPELIRALQpckppgecleFTSYSDVYSFGTVW 913
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_I       217 WEVMSFGERPyw-dmSNQDVINAI-EQDYR--LPPPMDCPAALHQLMLDCWQKDRNSRPRFAEI--VNTL 280
gi 74996665 1238 YEIYT-GKIPfegldGTASAAKAA-FENYR--PAIPPDCPVSLRKLITKCWASDPSQRPSFTEI--LTEL 1301
gi 73920239  216 IELAD-GKPPfa-dmHPTRAMFQI-IRNPPptLMRPTNWSQQINDFISESLEKNAENRPMMVEMveHPFL 282
4L01_B       228 WEICYNGEIPlk-dkTLIEKERFY-ESRCR--PVTPS--CKELADLMTRCMNYDPNQRPFFRAI--MRDI 289
gi 21263757  783 WEICYNGEIPlk-dkKLSE-KERFyAAQCQ--LATPD--CDELAKLMTHCMTYDPRQRLFFRAI--VRDI 844
4FVR_A       209 WEICSGGDKPls-alDSQR-KLQFyEDRHQ--LPAPK--AAELANLINNCMDYEPDHRPSFRAI--IRDL 270
gi 2499671   712 WEVFSGAPMHit-slEPAK-KLKFyEDRGQ--LPALK--WTELEGLIAQCMAYDPGRRPSFRAI--LRDL 773
gi 34761802  567 WEIYCGGEQPla-ayDTAKKLLFY-EDKHQ--LPAPK--WTELASVINSCMDYEPLHRPSFRAL--IRDL 628
gi 47222167  791 WEICYDGEVPlk-ekKLTEKERFY-ETECQ--LATPD--CTELAELMTHCMNYDPKKRPFFRAI--VRDi 852
gi 1171246   914 YELIC-GEFTfk-dqPAESIIWQVgRGMKQ--SLANLQSGRDVKDLLMLCWTYEKEHRPDFARL--LSLL 977
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