2HDI,3M8B,5FR8,3FHH,2IAH,1BY3,1KMO,5T3R,5FQ8,1XKW,4AIQ,4EPA


Conserved Protein Domain Family
Plug

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pfam07715: Plug 
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TonB-dependent Receptor Plug Domain
The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.
Statistics
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PSSM-Id: 336779
View PSSM: pfam07715
Aligned: 646 rows
Threshold Bit Score: 36.4816
Threshold Setting Gi: 81740726
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HDI_A        20 LKDAPASISV--ITQEDLQRKp---VQNLKDVLKE-VPGVQL-------------------------TNE-GDNRKGVSI 67
gi 81792943  126 VSSVD-TRTV--VTSEQLAQLp---LGRTAEAIALlAPGVVVns---------------------ggFDNgPLGGSLPSF 178
gi 81793509  137 VSSTS-SRSV--ITSQQLAILp---LGRSAEAIALlAPGAVAg-----------------------sGAFdNGSRSVVSF 187
gi 81792156  127 VSSVE-STTV--FTAEQMVSLp--vASDVSSVALL-APGAV--------------------------RGDsGLGAGNLAS 174
gi 81856341  149 QLDFAGTTTGlsIDVETLSKQvp-iARSVTALTLL-APSAVPgd---------------------tvGTFvNQGQSQAAV 205
gi 81748199  135 PEAPPNYVLS---QEDAIRMPg--gFGDALKAVQS-MPGISPmyqmytgasfqsaiqtfaqatnpdkPDKpNGEKGFLVM 208
gi 81748290  183 KDLESLSRYT--LQQEEIQRLpg-aQNDALKAIQT-LPGITAvppiglssssf----nnlvnsvgnsNPYsNSERGFLVM 254
gi 81444296  213 VATQMGAVEIpmVQIKNTPSIl--gESDVMKAIQL-MPGVQAg----------------------------VDGSAGLYI 261
gi 81506371   73 PDTGS-SVYR--FDTDDIARLplgdATPLNQVLLQ-APGVVQ------------------------------DSFGQLHV 118
gi 81740761  121 PKSELNTTLN--IGSNALEHLq---ISNVSDISAL-LPGGKT-------------------------KVPdLTSNNIFSL 169
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
2HDI_A        68 RGLDS------SYTLILVDGKRVNS--RNavfrHNDFDLN--WIPVDSIERIEVVRGPMSSLYGSDALGGV 128
gi 81792943  179 GGSAA------SENAYYLNGFNTTA---I----SNNLGGL--TLPYGAIDQQEIFTGGYGAQFGRSNGGVI 234
gi 81793509  188 GGAGV------TENAYYINGFNVSN---P----LSNLGGV--SLPYGAIDQQETYTGGYSARYG-RSTGGV 242
gi 81792156  175 FGGSSv-----AENGYYINGFDVTN---M----RTFLSFA--NIPFQGIGQLQIKTGGYGAEYG-RSLGGI 230
gi 81856341  206 GGASI------GENVFFVNGLNITN---F----VNGIGAT--LVPFEFYKSVEIKTGGYPAEFGRGTGAVI 261
gi 81748199  209 RGAGA------RANQFYFNGLPMSY--PF----HADGLTS--VINNNAIRSLELYSGSYSARYG-FATGGI 264
gi 81748290  255 RGGGT------LANGYYLDGFPMSY--PY----HLGDQSS--VLNNNIIKSFNVYSGAFPVQFG-FATGGI 310
gi 81444296  262 RGGSP------DQNLILLDGTPVYN--VD----HMFGFFS--VFTPEAIKKVTLFKSSFPARFGGRLSSVI 318
gi 81506371  119 RG-DH------ANLQYRINGVIIP----E----PISGFGQ--MLDTRFANQINVLTGALPAQYGYRTAGIV 172
gi 81740761  170 RDGGSsagnaaFGTAIEVDGVRIGNnsSF----GNMTGIDtrSISVADIESVEVITGVPSAEYGDLNSGMV 236
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