5AOR,2XAU


Conserved Protein Domain Family
OB_NTP_bind

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pfam07717: OB_NTP_bind 
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Oligonucleotide/oligosaccharide-binding (OB)-fold
This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself. The structure Structure 3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Statistics
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PSSM-Id: 311586
View PSSM: pfam07717
Aligned: 58 rows
Threshold Bit Score: 54.6545
Threshold Setting Gi: 75027634
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5AOR_A        965 QQLLDLL------------------QQAGFPEECM---ISHEvderi--------------------------------- 990
gi 150381456  590 AELLEII------------------KRI---ELPYaepa----------------------------------------- 607
gi 81916415   564 AELVELM------------------QRI---ELPLsqpa----------------------------------------- 581
gi 81835426   617 RQLKEMS------------------ASIGENKRRSknkSLTSrgsvgkiryaeld------------------------- 653
gi 81656205   595 AQLAEIA------------------SELGLITRDEahaDAEQpdaqmtqk------------------------------ 626
gi 81860235   604 RQLRLLCeelgwseepagamlapllAGASAPVREDg-qAHRAtrgqlhraarlaregkpdpaappaqa----------ka 672
gi 81858414   720 tvLQALL------------------AGQGTSTQSEh-rGHTPsrgqlhraarlarersavpkvtqntqsvkavagqsvsh 780
gi 81622229   601 RQLTLIC------------------RELKLPFGRPakaEARKpeakkgasa----------------------------- 633
gi 81847251   600 SQLRQMC------------------KELKFKVGDPlpaSRPGleirqlplnq---------------------------- 633
gi 81846821   601 RQLEQVG------------------LQLGWSAKEN---VAGTa------------------------------------- 622
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5AOR_A        991 -------------------dgddPVLDVSLALLCLGLYPNIC--------------VHK------------EK-RK--VL 1022
gi 150381456  608 -------------------fgskENGLNIKKALLSGYFMQIA--------------R-D------------VD-GSgnYL 640
gi 81916415   582 -------------------fgseQNRRDLQKALLSGYFLKVA--------------R-D------------TD-GTgnYL 614
gi 81835426   654 ----------pakadqeqpvvdsDKYALIHQALMTGLLSGIA--------------MAG------------DK-NE--YT 694
gi 81656205   627 ----------------krqqvdaVAYENLHKALITGLIGNIG--------------MKN------------QEgDD--YQ 662
gi 81860235   673 aaaksspadatdaavrtsereraAAYQALHRALLAGLPTQIG--------------HRT------------EK-GD--FL 723
gi 81858414   781 agmqaqfavppndaphigereraAAYQALHRALLTGLPIQIG--------------HRT------------EK-GD--FQ 831
gi 81622229   634 ---------------dnerevpgIDYAAVHKAILSGLLSQIG--------------QKA------------EE-GD--YL 669
gi 81847251   634 --------------qaahslccaWDADGIHKSMLAGLLSMMGmqvvrepkasdfagLTGsararamkraqkQSkND--YQ 697
gi 81846821   623 ------------------------SPDIIHQSLLSGLLSQIG--------------ARD------------GDsRE--FS 650
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
5AOR_A       1023 TTESKAaLLHKTSVNC--------SNLAvtfpypFFVFGEKIRT-RaVSCKQLSMVSPLQVILFgSRKI 1082
gi 150381456  641 MLTHKQ-VAQLHPLSSysi---tkKMPE------WVLFHQFSISeN-NYIRVASAVSPELFMQL-VPQY 697
gi 81916415   615 LLTHKH-VAQLSPYCSyrnrrtpaQPPT------WVLYHSFSISkD-NCLCIVSEIQPEMLVEL-APPY 674
gi 81835426   695 GA-GGL-KLFLWPGSGif-----eAKPK------WIVAAELVETaK-QYARTCARIQPGWIEAV-APHL 748
gi 81656205   663 GA-RGV-AFHVFPGSGlk-----kTKPK------WLVAAELVETtR-LYARCVAKIEPEWVEKL-APHL 716
gi 81860235   724 AA-RQR-RFVPFPGSAla-----rKPPP------WILAATLLDTqK-VWGMTNAAIEPDWAIAE-LPHL 777
gi 81858414   832 AP-RQR-RFMLFPGSMla-----kKPPP------WVLAANLLDTqK-VWGLTNAAIEPDWVIAE-LPHL 885
gi 81622229   670 GA-RQR-RFWIHPSSGia-----rKRPQ------WIMAAELVETtK-LFARMVAKIEPDWLEPL-AGHL 723
gi 81847251   698 GA-RGT-RFALFPASAva-----kKTPS------WVMSTELVETsR-LWARYSAAIDPAWAEPL-AGQL 751
gi 81846821   651 GS-RGT-KFMIFPGSPls-----kKPPQ------FIMAGQLVETsR-LWARDVAKIEPEWVEKI-AGPL 704
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