Conserved Protein Domain Family
Peptidase_C26

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pfam07722: Peptidase_C26 
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Peptidase C26
These peptidases have gamma-glutamyl hydrolase activity; that is they catalyze the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to pfam00117, but contain extensions in four loops and at the C terminus.
Statistics
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PSSM-Id: 311591
View PSSM: pfam07722
Aligned: 37 rows
Threshold Bit Score: 185.52
Threshold Setting Gi: 74802497
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3FIJ_A        5 PVIGITGNRLV-KGVDVFYGHRVTYTQQryvdAIQKVGGFPIALPI-DDPSTAVQAISLVDGLLLTGGQditpqlyLEEp 82
gi 81658739   5 PLIGLNAD----FRAAARSTPAFAYIASgyyqAIINAGGIPVLVPPqADEESVSRVLDAVEGFLFIGGGdldprndGFMl 80
gi 81530302   3 PVIGIT------ALCKNENGNLFTFLNYyyskSIVMAGGTPILIPLgGEDDDIKNYIDIIDGLILSGGEdinplfyGENp 76
gi 81746820   8 PVIGITSSMET--------DCSQYTINNrnirAIENAGGIPVMLPYlKNDEDIDYMMNKLDGLYLTGGYdidptlfGEEp 79
gi 81417039  37 PVIGLTANY----------NTSGSCIARayteSVIRAGGLPLLIPLtTDIEVIRHYATFIDGLILSGGDdllpsylGEDp 106
gi 81484590   5 TIIGISSSVIV-DESGSFAGYKRAYVNKdyvdAVVRAGGVPLIIPFtTNKEVIISQAQLIDGLILSGGHdvspynyGQEp 83
gi 81484919   4 PIIGISASMIYeEKDELFLGDKYSCVAYsyvdAVYKSWGIPVTLPIlKDVSAIREQVKLLDGLILSGGRdvdphfyGEEp 83
gi 81480251   4 PIIGIVGNISY-ETEGVMIGEERIYVMRpyveSVLKAGGVPVVLPIvLDKDTLKKQVEKVDGILITGGQdvnpllyNEEp 82
gi 81449411  20 tVVGVAANL---CPVDAEGKIIHSSVSCrfaeIIRQVGGLPLVIPVg-DESVVRDYVEMIDKLILTGGQnvhpqfyGEKk 95
gi 81777644   3 PVIGIVSDLDV--------EKDGYVCLAnyvrAIEKAGALPVILPYt-NAESVSSVLELLSGVVLSGGGdfpaelyGANp 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3FIJ_A       83 sQEIGAYFPPRDSYEIALVRAALDAGKPIFAICRGXQLVnvalggtLYQDISqv--etKaLQHLQRVDe---QLgSHTID 157
gi 81658739  81 hPSVHPMDAARETSDRMLMAEIAERRMPVFGIGVGMQLInvqqggnLFLHIKedlpeaV-PHFDAQD-----VNhRHTLN 154
gi 81530302  77 tNKINYTSPERDEYEKKLYLKALEEDMPILGICRGLQLMnsvsggnLYQDINmq--veN-SNGHSP-VgiskSNlYHTVN 152
gi 81746820  80 lPGLGIIIPERDRSEIAYVEKMIERDKPILGVCRGSQILnialgglMYQDIYsq--ldT-VKLLQHRQkapiDHrSHFVH 156
gi 81417039 107 iPTLGEVNPERDRGELLLVAEATRRNVPILGICRGHQLLatafgggMYQDIYaq--seN-P--VGHNPkipiSFaAHQVR 181
gi 81484590  84 sQKLGETFPERDTYEMILLEESKKRNIPILGICRGSQLInvaaggtLYQDLSli--pgN-I--LKHNQvnkpTLkTHIIK 158
gi 81484919  84 lEKLEAIFPERDVHEMALIRAAIDLKKPILAICRGMQILnvtyggtLYQDISya--pgE-H--IKHCQvgssYQaTHSIN 158
gi 81480251  83 iEKQGGITPDRDWYDIEVIKYAYSLKKPILGICRGIQVMnvalggtLYQDISq----iP-TAYIKHSQrakpDLpTHTVE 157
gi 81449411  96 tVESDDYNLVRDEFELALLKEALRQNKPIMAICRGVQLVnvafggtLNQEIEg------------HWQgl-pFGtSHSIE 162
gi 81777644  74 hSTLQAMIPARDTFEFALARSALEKSMPILGICRGMQLLnvvsggaIYPHTLd----eL-PDARDHRDgtplSEmVHKVH 148
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3FIJ_A      158 IEPTSELAKHHP--NK---KLVNSLHHQFIKKLAPSFKVTARTA-DGXIEAVEGDNLP-SWYLGVQWHPE 220
gi 81658739 155 VESDSLIGRVYGd-GE---IRVTSRHHMAIDEVAPGFRVTARCP-DGVIEAIESEMID-WFALGTQFHPE 218
gi 81530302 153 IVKNSKLFNIFCe-EE---IKVNSFHHQAIKKLSDKFIISAQSS-DGIVEGIEHKYNT--FVLGVQWHPE 215
gi 81746820 157 VKEGSLLYQLTGl-DK---FKVNSYHHQTNNRVPEDYQICATAS-DGIIEAFESEKHR--FVLGLQWHPE 219
gi 81417039 182 LQGDSVLARILGl-SDgelLGVNSLHHQAVSRVPKPFRVTALSS-DGVIEAMEAYP-E-KPILSVQWHPE 247
gi 81484590 159 IEENSIISSVFG--KE---TMVNSFHHQAIDKVADDFKVVARAN-DGVVEAIEHKTYK--FLVAVQWHPE 220
gi 81484919 159 IDKNSILFKMADksEI---ERVNSFHHQALKQVAKGLKVVATAP-DGIIEAVERENEDeVFVIGVQFHPE 224
gi 81480251 158 IKEGSRLYNILG--KT---IAVNSFHHQAVKEVAEGFKIVAQSK-DGVIEAIELEKED-YFVVGVQWHPE 220
gi 81449411 163 TVEGSVVAKLFG--KE---SQVNSVHRQSIKDLAPNFRVTAIDSrDQTIEAIESIDEH--RIIGLQWHPE 225
gi 81777644 149 IEPNTKLSRLCG--EHaaaFEVNSMHHQAISRLAPGFVVSARAD-DGVVEAIEATDRP--FVVGVQWHPE 213
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