Conserved Protein Domain Family
RVT_2

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pfam07727: RVT_2 
Reverse transcriptase (RNA-dependent DNA polymerase)
A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses. This Pfam entry includes reverse transcriptases not recognized by the pfam00078 model.
Statistics
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PSSM-Id: 336784
View PSSM: pfam07727
Aligned: 7 rows
Threshold Bit Score: 336.264
Threshold Setting Gi: 74587170
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74588548  1000 NTWSLEPLPEGRKAIGVKWVYTIK-----D----TGRYKARLVALGYRQQAGVDFL--ETYAPVIRGESIKLIFALASKS 1068
gi 122245261  916 KTWRLVDLPSGHRPIGLKWVYKLKkdaqgV----VVKHKARLVAKGYVQRAGIDFD--EVFAPVARLDSVRLLLALAAQE 989
gi 74591449   889 QVYTVEKTPKNVVPLKTMWVHTYKtn-dlK----NHNYKSRCVVMGNYMVENRDFDphAISSPVVDLTSIRLLSAIAVEN 963
gi 74587170   122 DVYEEVPIPTGVKPISMGWVHTEKidslkG-----VVRKSRCVVHGNRQKEKLDYDpfSVSSPVIDLVTIRLLTIIGCEL 196
gi 323347569  146 KTYRLVSLPKQRRALGSRWVFTIKd---------SGKYKARLVAQGHTQKAGIDYQ--ETFAPVIRYDSVRLFLALASCL 214
gi 294659635 1016 NTWDLVSLPKDRKAIGNRWVFTKKd---------DGRYKARLVAQGFSQVPGEDYL--DTFSPVIRYESVKLLLAFSAVD 1084
gi 20152520   834 EVYTVVKNPKNVKPIPTTWVHTHK-----IndlkEVQYKSRCVVQGFRQIANEHYDtsKVSSPVIELSIIRLLTAIAVEY 908
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74588548  1069 KLKIHSIDVTTAFLNGEISEL--IFVKQPPGYEDKkrPNHVCKLNRSLYGLKQSPLMWNIKLNDVLIKEGFRRLGGDLGI 1146
gi 122245261  990 GWMVHHMDVKSAFLNGELIEE--VYVVQPPGFEIDgqENKVYRLDKALYGLRQAPRAWNTKLDCTLKKLGFKQSPLEHGL 1067
gi 74591449   964 NLVMHQLDIASAYLNASLEDGrvIFVRPPRGFEVK--PGYSWRLHKSVYGLRQSAHNWYSHFKNVLEANGLKQTLHNDGI 1041
gi 74587170   197 GMTIQHLDVESAYLNASITHSnpIYVFPPKSVPLK--KNHCWLLKRSVYGLKQSGFEWYHTIKRVLEDIGFNQVLHNDGL 274
gi 323347569  215 KLIVYQMDVDTAFLNSTMDEP--VYVKQPPGFVNErnPDYVWELYGGMYGLKQAPLLWNEHINNTLKKIGFCRHEGEHGL 292
gi 294659635 1085 NRVVHQMDVDTAFLNGTVEET--LYMKQPVGFINEnePEKVCKLNKSLYGLKQAPICWNTTISDFLAEHRFNRIDTELGI 1162
gi 20152520   909 EWPIHHLDISSAYLHADIDYEksIFVKPPPGSNID--SGKCWQLNKSVYGMKQAGYMWYQCITKVLMDLNFEPDTAISGM 986
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74588548  1147 YISKD--K--R-TIMGVYVDDILICGPSDSEIEQVKNNVRKYFSITDNGLCRKFLGINVYQQANE-IRLSLNDYIRRMIE 1220
gi 122245261 1068 YARGD--GsgR-LLVGVYVDDLVIVGGDSGMIKGFKEQMKAEFKMSDLGPLSFYLGIEVHQEAGI-ITLKQAAYASRIVE 1143
gi 74591449  1042 FWKNY--EngDvLYVSVYVDDVFMIATNEKIIKEFVAMLETYFQLQYFGEATEYLGIQFRKTPDG-YTLDQIPFLEKLVA 1118
gi 74587170   275 FHIEY--EegSvIYLGLYVDDILMVGSSQKVIDNFVDQLRDHFEVKVFGEISNYLGIEFRKTESG-YILSQEKFLKKLLK 351
gi 323347569  293 YFRSTsdG--P-IYIALYVDDLLVAAPSPKIYDRVKQELTKLYSMKDLGKVDKFLGLNIHQSSNGdITLSLQDYIAKAAS 369
gi 294659635 1163 YVR----G--N-IIIGLYVDDILISGKDMKEIEDVKKMLASKFKMKDLGVAKKFLGINIAQDTNG-IKICLYDYIGKVLQ 1234
gi 20152520   987 FCKYFgeN--KkLIVALYVDDMFLTSSNITILNDFKLELAKHFDLKYFADISEFLGIEFIQIAGG-YRLSQHNFLNSVIK 1063
                         250
                  ....*....|....*.
gi 74588548  1221 ELKLSvsETNPVSIPS 1236
gi 122245261 1144 KAGLT--GCNPCATPM 1157
gi 74591449  1119 TFNIQ--DSYGKDIPI 1132
gi 74587170   352 DFKLD--DSYGKNIPW 365
gi 323347569  370 ESEIN--TCKLTQTPL 383
gi 294659635 1235 DFEMT--DANTVTTPT 1248
gi 20152520  1064 KFNLT--NNYGKYIPI 1077
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