Conserved Protein Domain Family
TipAS

?
pfam07739: TipAS 
Click on image for an interactive view with Cn3D
TipAS antibiotic-recognition domain
This domain is found at the C-terminus of some MerR family transcription factors. The domain has an alpha-helical globin-like fold. The family includes Mta a central regulator of multidrug resistance in Bacillus subtilis.
Statistics
?
PSSM-Id: 311604
View PSSM: pfam07739
Aligned: 284 rows
Threshold Bit Score: 38.703
Threshold Setting Gi: 81691233
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QAO_A       131 YEEEARKLWGD-KV------------VEKANEKVNNXSEKEQLTLKESFDAEFRHLASVrKLTPESEEAQLEIDHFFHYL 197
gi 122483520 159 iAELAVKQYGSiENytraseknlenyLKNGT------ETIDVEESMVKTDSLTRQLTADlSKDVSSQEIQTMILQLIDLC 232
gi 933361179 160 iAEAAVRQYGSiENftkamkenfqnyLSEG----PVISETEVDGIMEKTELLTKRLTADlTRDPSSAEVQAAVSELIAFC 235
gi 488662210 159 IAQMAVKQYGSiEKftkameenlqhfLENG----PGFTQKEADEAVDKTDTLTKKLTADlSKEAGSDEVQKIAGELVSLI 234
gi 503145133 159 iaglAIRQYGSvEKytaamr-dsishFSENM---EKMEAMKSDGTVQKNAALMEKLYSSrEKDPASPEVQAIVGELIALG 234
gi 496093166 159 iAKTAVEYYGStAAytdamk-ynlehFSEIM---EKLEHIRQQNYGKRNQQLMEKLLQDtTRDPASAQVQQIIYDMQHLI 234
gi 496596937 159 iAQTAVEYYGSvEKytdamk-eslshFSENMENMEKMQKIKEKGCVEKNKDLIEQLTSNvSRDVKSDEIQNIIGQMLNLL 237
gi 501153601 159 iAKLAIQQYGSiEKyteamk-anlknFPETMEKLQSLGKDK-DDYLTRSKEINEKLTKDlTLDVASNEVQELVKEMVLLS 236
gi 496594825 165 syakVVEWYGGkd-----------eyLSVVK---NPVSKEIAESFNKRIEVILQKLIAKrGCPLDSFEVREIVGEYGFVV 230
gi 225205756  20 gyakVVEWYGGke-----------qfLSVAN---NPISKEAAESYNQQFDNLLYKLAAKkVCSPDSSEVRELVSEYGFLM 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
3QAO_A       198 NdthGnI-----YSLEAFASLGEXYVNDERFTKNIDQFG-DGLSQFLQEAXTIY 245
gi 122483520 233 Dq----GhngldMGENYWAFMAENYLTNPLFISTTDQKYgEGAAEFIGKALKIH 282
gi 933361179 236 Ee----SnrgidMGENYWLLTAEAYQSNPMYLEVNDRKYgEGASKFIGSAIKEY 285
gi 488662210 235 Ne----SnggmdMGSSYWSFMVNNYMTNPAFQEITDRKYgEGASEFMGKALKVY 284
gi 503145133 235 Et----AelnidKGEHYWDMMIDWYLHNDALIKTIDGQKgPGASAFVGRALACY 284
gi 496093166 235 P---EeEacgsnPGMHQQKLLIDSYLHNEALIQQTDQRYgRGASRFMGKALRIY 285
gi 496596937 238 D---EeDqptmdLGENYYDKLIDGYPYNPKLIEAMDQQYcKGVSKFIGEALQYY 288
gi 501153601 237 Ne----VnkgfdMGENFWDMVIEGYLHSEQLIKANDSLYgEGASAFIGRALEEY 286
gi 496594825 231 K-----QlsqmkEEREGMLATARFY-RNEPSKSKLDETYgEGAAEFFAEAIEAF 278
gi 225205756  86 K-----QlsqikKEHGLMVAQAQYY-RNEKIKPMIDEKYgNGTAEFFAQAFEAF 133
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap