Conserved Protein Domain Family
Nop53

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pfam07767: Nop53 
Nop53 (60S ribosomal biogenesis)
This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumor suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.
Statistics
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PSSM-Id: 336806
View PSSM: pfam07767
Aligned: 139 rows
Threshold Bit Score: 160.527
Threshold Setting Gi: 303270943
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966   17 KGKKAWRKNVDVTEVQEGLRLLKdeeiKGGVLAEKPSEELFVIDKK--GSAE---------------I-RNAYFKQ-H-- 75
gi 942404375 124 HKKKAWRVTSNVEDVERFLESKRlderLGAPLEERPSDSFFVVDTKteADKP---------------L-KRELTKKrKik 187
gi 685302376  10 KGKKAWRANISTEDIEDFFEKTTkdalSGGNLSAAPSDDLFRVEKS--HDVP---------------V-KRKIEKSrE-- 69
gi 193648081  10 RLKKDWRRKIDVTDVDTYLEGKRlqerIGDSFSQKKDEELFHIDTS--GKKqksk---------kksLn----------- 67
gi 642913995  12 KSKLAWRKHVNINDVEEFLEDQRleerLGPSLASLNNEELFQVDTK--PSEpeslsi------------knrkkLK-Lq- 75
gi 328793336  14 KTKKAWRKYTDTKDIEKFLENSQleerLGS-FAIHKDSELFSISIA--PEIfskq--------krreL------LK-Lk- 74
gi 746832219  19 KTKRSWRKYIDIKDVDTFLDNNRleerLGTPFSKRIDTQLFSIDKT--ADVtenvis----kraarlA------LK-Nk- 84
gi 307207709  13 KTKKSWRKHIDTKDVDAFLEDIRleerMGPPLSKQANSELFTIDRT--AGKtktvvss---kraarlA------LK-Ek- 79
gi 156551285  14 KTKKSWRKHVDTKDVDSFLDNERleerLGTPFAQRKDEELFAVDRT--RDESalqessglskkqrreL------LK-Nt- 83
gi 241653566  15 NRKKTWVKHSDIKDIEGFLEDQRlderLGGAVSTKPDEELFYVDKS--PAApkp----------kraVqSKR--ER-Rn- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966   76 --KPLKADEILAQRSAIPAV-D-TRKRL-NskvtdgviepksKKHKSDwV---TRK--EWLRLKQVAKEANPT------- 138
gi 942404375 188 eiGPLRCYAILTPNSAVIDP-LkKRNRV-Rl-----------PEERGDpLl--RKVmeERRAKGKIPTRFLQSmkhhqen 252
gi 685302376  70 --KVLRCDSVLKKNPFVQVVsSsKPKSK-Is-----------KKKKTNaV---ESKtpKLAQssv--------------- 117
gi 193648081  68 --APLKCLSILQSTSAI-PP-LaKRSVKkY------------KKNNKKdDdfdKNIkpLKKKGGIVKKKEAKElnki--- 128
gi 642913995  76 --KPLRCFSILEPHTKVPDP-IkKRNRVrS------------KEERKNel--iKKKeaENRAKGILKHRELQAlrdka-- 136
gi 328793336  75 --EP-RCFNILKPHTAVPDP-ItKRNRVrT------------KDERKNal--vLKKeaIRKSQNILTLKEKLRlknkm-- 134
gi 746832219  85 --EP-RCFASLKSHTCVPDP-IsKRNRVrT------------KEERMNsi--lRQRevERQVKGVLKLKEKEAlknri-- 144
gi 307207709  80 --EA-KCFASLKPHTQVPDP-IsKRNRVrT------------KEERMNsi--lRQReaERKLKGILKLKEKEAlknra-- 139
gi 156551285  84 --EP-KCFAILKPHTAVPDP-IvKRNRVrT------------PEERKSii--rKQKeaERKLKGQLKLKERVAiknrl-- 143
gi 241653566  79 --RKLTCYLNLEPSSKV-AP-PtKPRRVrD------------PEERK-------PAavRRVQQQRLAKRHEQAvtqrl-- 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966  139 ------QTAe----ESEL-------YDPWADSEDPtp-----vEDP-----------QFDYLEKPKPKV----------- 174
gi 942404375 253 vealakKKKperlrTTFD-------FDLWGDAGDSlm-----iGDK-----------KVSALDLSDQLKtytmekmgnri 309
gi 685302376 118 ------------ddDSVM-------MDLWGDDNKGed-----eGN----------------------------------- 138
gi 193648081 129 --lkakVKTl---eLKENstkdlfdKDLWTSYREPgqrkdkliKNVikwlpsevlnhNAKIL--PKLSN----------- 190
gi 642913995 137 --tnenKKQa---iPK-Rgd---fnQNIWDQ--EDnl----neKNEwfsns--ttkhNLVGT-GKSRKT----------- 187
gi 328793336 135 --iaakKKLn---kPK-Rde---fnINIWKE--KNtk----diNIDwmssd--tirhTLTHF-GIKKKR----------- 185
gi 746832219 145 --lakiASIn---rSK-Ske---ikEDIWNS--INvli--petITEwmssn--sirhTLKHL-GIKKRK----------- 197
gi 307207709 140 --lakaAFKk---rPK-Rge---fkTDLWDV--TKnvl--petVTEwms------------------------------- 175
gi 156551285 144 --lakeKRAn---qPK-Rge---fkVDVWKK--EPive--aelKSEwltnd--tvrhTLANT-GKKRKR----------- 196
gi 241653566 134 --rsvaRKAk---qANGHsdf-tglRDIWAD--EE--------KKAdsgldpeletyIAEYT-KERRPN----------- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966  175 --APPTIKQPPISLAANGkpipS-VRKPDAGISYNPSFEDWDRLLqekgheAVEAEKKRLEEERKEQERQRLi--AEAqn 249
gi 942404375 310 ysRPPTM---FFKTTGLK----P-VEYPHPGTSYNPTFQDHQALLk----eAYNLETKEMKEEVRTRRRLGPmlkKIPvq 377
gi 685302376 139 ---PRKIWKM---TSTIP----A-VEVDPAGCSYNPTAESHEDMLa----eAVAQEMQKVYKTELGPEPVPLtidGNNni 203
gi 193648081 191 --KKMSHPSQ---TTCKA----EdMKCPHPGLSYNPTIEDHVSLLa----nIAEKETELIKHEAHMNRVTRNlf-kQVsk 256
gi 642913995 188 --VKTPKRPK---SSVLP----P-VEPPHPGMSYNPSYEDHQDLLk----tIVEKETKIIKEEEHLNRVTRDmf-sKVse 252
gi 328793336 186 --IPSSLHKK---PSNIP----A-VEAPHPGTSYNPSFEDHQKLLl----eVAQKEMELIKEEEHLNRVTTKmf-kKVsl 250
gi 746832219 198 --LP-LLCKK---PSVLP----A-VETPHPGTSYNPSYNDHQELLh----nIVQKELELMKQDEHLNRVTTQmf-kKIsl 261
gi 307207709 176 ---------------------tdtVEAPHPGTSYNPSYTDHQKLLn----dIAQKELELMKEEAHLDRVTTKmf-kKVpl 229
gi 156551285 197 --VPESLHKK---PSVLP----A-VNAPHPGTSYNPSFKDHQELLa----qVAAEEVKLMKEEEHLNRVTNKmf-rKVta 261
gi 241653566 186 --IPAHRYQK---PSLLP----A-VQPPHPGASYNPAPDAHQELLh----eAFLIEQKRLKEEQHIDRVLTKml-pTRet 250
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966  250 d--------------------------------------------------dgEV----KSDdesawegfes-------- 267
gi 942404375 378 r--------------------------------------------------keEqwwsemtqgladeeepa--------- 398
gi 685302376 204 edeagllsvcnriingksayflgvdngsegeedaeaaneeseagnktarttkrV-------------------------- 257
gi 193648081 257 e--------------------------------------------------knEQmiieELTeglpgftddtvkev---- 282
gi 642913995 253 k--------------------------------------------------qkNSmwmeEMSqglpqastqqsdn----- 277
gi 328793336 251 k--------------------------------------------------ekEDnlikEMSeglklednqdfned---- 276
gi 746832219 262 q--------------------------------------------------krDEnmmkEMLeglpknqttssfksiee- 290
gi 307207709 230 n--------------------------------------------------krDEnlmkEMSeglpikkqttenskptke 259
gi 156551285 262 k--------------------------------------------------qkDAdnltEMSeglplpnqkqdddsd--- 288
gi 241653566 251 m--------------------------------------------------ptEEdmiaEMSqglyddpssdeaegde-- 278
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966  268 ---------eyekpewlnKKRpARKTKAERNRIKRRKEAERKARWEAKMKQKEEQLEQAKAIAEQVQQRQLERSR--ESG 336
gi 942404375 399 ---------keeeeevpcirptkpkTRKQKIRAKALKWQDMRRKKLKEAKKRLLEFDRLRSIRREIRKSEELTAKr-iEI 468
gi 685302376 258 -------------------------TRVVLNKRARQKALRKEETKEKHKEKLSKEIDSLPKIIKEIAEEDKEKLNkkIRQ 312
gi 193648081 283 ----nedtsefkainpptTRD-NQKTIKKRKIQRRLRNEERQRMNAKIEKKKVSDLYRLRYIREELDELENTTNKk-KLK 356
gi 642913995 278 -----esdgeyksinpptK-N-RKKTQQQRRKLREQKKLELLKQIAKKEKKKISDIHRIKLLKNQIEKREKTTQIl-REK 349
gi 328793336 277 ----enndpivksinppvK-N-KKKTRVQRRKQKEQKNLVHKKQQEKVEKKKISDIYKLRVLDRQLAAKEKKEKVl-HEK 349
gi 746832219 291 -dheeenssitiannkskK-N-IKKTLVQKRKQREQKQAINERTLMKLEKKKISDIYKLKTLQKQIEAKERKQESl-RQK 366
gi 307207709 260 gdveeedssvaianskpvK-N-IKKTLVQKRKQREQKQAANERTLAKIEKRKVSDIYKLKMLKKQIESKEKKEDFl-RQK 336
gi 156551285 289 ----edndpnvrsinppaL-N-VKKTLVQRRKQKEQRKLQQQRLKQKIEKKKVADIYHLNHLGKQISKKEQKLGLl-KEK 361
gi 241653566 279 --vagddgarsgqanppvRAE-DRKTKQKRRRELEQKRIQSAAKVRKTERVLANQVYRIPTIKAELRREAEISEEr-QKR 354
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 74668966  337 DD--SseegddaaLRRKPLGKARVPEKPLEVVLPDELQDSLRLLKPEGNLLDDRFRTL 392
gi 942404375 469 RKkeKea----kmFKPAMLGRHKYEPPPIEVNLSEEITGTLRGLKTEGHVLIDRFKSM 522
gi 685302376 313 TIakEev----lkIRPPRLGKHKYEAPPVQVLLTEEMTGSLRKLKACCTLARDRFKSL 366
gi 193648081 357 RLqkRql----nnISTRRLGTNKFTESSDTFALPKDLKGTLRETEPQGNIFKDCFESL 410
gi 642913995 350 RKkvQel----kkTEPKRLSAIKFEECDLEFNMGPDIAGNLRNMKKEGNLLTDRFKSL 403
gi 328793336 350 RLkkKil----ktVGTKTLSKVKFEPLELDFKLGSELTGNLRNSEPTGNLLKDRFKSL 403
gi 746832219 367 RTkkRes----esLMPKTLSKTKFEPIDPDFQLAEELTGNLRNFKPSNNLLKERYKSL 420
gi 307207709 337 RMkkHer----esTTPKILSKTKFEPLDPVFQLSEELSGNLRNCNPSKNLLKDRFKSL 390
gi 156551285 362 REkiKak----keLEPKVLSRHKFEPLEQEFLMGDEIAGNLRNTTPAGNLLKDRYKSL 415
gi 241653566 355 RQerEdd----klYQANRLSKFKFEEPDMELKLPEELTESLRQLKPECNVLEDRYKSL 408
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