Conserved Protein Domain Family
GSG-1

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pfam07803: GSG-1 
GSG1-like protein
This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumorigenesis of human testicular germ cell tumors. The region in question has four highly-conserved cysteine residues.
Statistics
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PSSM-Id: 311652
View PSSM: pfam07803
Aligned: 39 rows
Threshold Bit Score: 136.213
Threshold Setting Gi: 558105306
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187471144    5 RRNRSLLSVVLNLLALSFSVAAFFTSYWCEGTHKVVKPPCLSaVKSKNCQALAlnss---------stgS------D-AT 68
gi 557023253    6 ccrrttlalvlnlvalTLSSTALVSTYWCKGTQKVPKPSCNKqQ-TTKCIKTV----------------GqvenetA-PS 67
gi 542182567   21 RKCRALLSVGLNLVALFFSTTAFITTYWCEGTQRVPKPNCSK-QRHHNCIDY-----------------G------V-NE 75
gi 348532698    5 RRSRTLLSLSLNFFALFFSITAFITTYWCVGTQRVPKPKCSK-LRTHQCIDY-----------------G------V-NE 59
gi 556960852    5 RRCRALLAVSLNFVALLFSTTAFITTYWCEGTQRVPKPNCGK-GKKTNCINY-----------------S------G-ND 59
gi 1023023807   5 RRCRALLAVCLNLLALLFSTTAFLTTHWCQGTQRVPKPNCGR-DKKTNCLNY-----------------S------G-NS 59
gi 395747642    5 RRVRALLAVALNMLALLFATTAFLTTHWCQGTQRVPKPGCGQ-GGRANCPNS-----------------G------A-NA 59
gi 1040199507   4 ARRQRALTLLPIGLALTLSLIAVSSSHWCQGTRRVTKPLCQDpVGGPHCIHP-----------------I------EsSG 60
gi 149261929    4 aRWQRMLTLLPICLALAFSLTAMGSSHWCEGIRRMTKPLCQDlLGGLNCIHFS----------------R------SsSS 61
gi 637367713   23 RRGRALLAVGLNLLALLFSATAFGTTHWCEGTQRVPKPTCGP-LARTNCLDYGyreeeeaaaarlhgngS------A-NA 94
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187471144   69 DtngtlNPNVVH-------------YNWETGDDKYAFKYFHTGFWFSCEKHQGE--EACRSFIELSPDSE 123
gi 557023253   68 G-----GGDNVQ-------------YSWETGDDRFAFQYFHTGIWHSCEETIDGrgEKCRSFIELTPPAE 119
gi 542182567   76 T-----DQNKVH-------------YSWETGDDRFLFRRFHTGIWYSCEENIHEsgEKCRSFIDLAPASE 127
gi 348532698   60 T-----DPNKVV-------------YSWETGDDRFLFRQFHTGIWISCEENIHDesERCRSFIDLAPASE 111
gi 556960852   60 Tsn-eaNQNVVH-------------YSWETGDDRFIFRYFHTGIWYSCEENIYSngekcrsfidlapase 115
gi 1023023807  60 TandtaGSHGVH-------------YSWETGDDRFLFRYFHTGIWYSCEENLSGlgETCRSFIDLAPASE 116
gi 395747642   60 TangtaAPAAAAatasgngppggalYSWETGDDRFLFRNFHTGIWYSCEEELSGlgEKCRSFIDLAPASE 129
gi 1040199507  61 SgrsdaGGQAVQ-------------YIWEMGDDKFIQRRFHVGLWLSCEETFSStgEVCRSFQSVVPAEE 117
gi 149261929   62 TgskhdDSQAVQ-------------YIWETGDDKFIQRRFHAGLWQSCEESLNStgERCRCFLGIVPAEG 118
gi 637367713   95 SaphgpSDSVVH-------------YSWETGDDRFLFRYFHAGIWYSCEENINDpgEKCRSFIDLAPASE 151
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