Conserved Protein Domain Family
RED_N

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pfam07808: RED_N 
RED-like protein N-terminal region
This family contains sequences that are similar to the N-terminal region of Red protein. This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region, suggesting that these proteins are expressed in the nucleus. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated of that the protein self-aggregates extremely efficiently.
Statistics
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PSSM-Id: 311656
View PSSM: pfam07808
Aligned: 30 rows
Threshold Bit Score: 140.122
Threshold Setting Gi: 74866287
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74799447   86 QLKKQED-NKLAELAEKYRDRARERRDGA--------------------N----------PDY-QNLDSS-SSTSAYRAV 132
gi 75219484   12 TARRREE-KLEESDNPKYRDRAKERRENQ--------------------N----------PDY-DP-----SELSSFHAV 54
gi 75023280   72 TEADEDE-AALKNILKNYRDRAAERRKQG--------------------D--------------EKEDPS-KLTAAYRAV 115
gi 358337845  91 hrRDQAK-ESAAEPTPRYRDRAKERRDGK--------------------LvapseegadeRDYeQDEEAL-SRTADYRAV 148
gi 674586127  82 EDGDGDE-SRKSDKAPKYRDRARERREGKissnmesldstiheeavearD----------DEE-EDPNRL-IHTADYRAV 148
gi 341890233  71 TEADEDE-AHLKNILKNYRDRAAERRKQG--------------------D--------------EKEDTT-KLTAAYRAV 114
gi 356556428  13 PIRRKEE-KPEEPEVPKYRDRAKERREDQ--------------------N----------PDY-EQ-----TELG-FHAV 54
gi 586695718  12 MARRKEE-KQDEPELPKYRDRAKERREDQ--------------------N----------PDY-EP-----TELGSFHAV 54
gi 357157713  16 MARRKEEnKKEEPETPRYRDRAKERREDQ--------------------N----------PDY-EP-----TELGSFHAV 59
gi 302840939  54 aDKSNAE-DAEDDGAPKYRDRAEERRRGK--------------------N----------LDY-EDASAVlSALSGSGGV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74799447  133 APDVk--sGLNAAERRRQQIQESKFLGGDMEHTHLVKGLDYALLQKVRSEIVAKENE---QEEEM-----EKLVDIEPSA 202
gi 75219484   55 APPGa--vDIRAADALKISIENSKYLGGDVEHTHLVKGLDYALLNKVRSEIVKKPDG---EDGDG--------------- 114
gi 75023280  116 PGDAr--sAQDQADLRKQAILESKYLGGDLEHTHLVKGLDYSLLNKVRSEIDKSDDD---DDDDIdtafdEKVTSSSSSS 190
gi 358337845 149 APTSa--aGQSLAERRRMLIQESKYLGGDMEHTHLVKGLDYVLLQKVRLEIQNKELE---AEKVL-----DAELSKPEVS 218
gi 674586127 149 APTt----GADHAAERMRAIEESKYLGGDMENTHLVKGLDYALLKKMRRQIRSMELQ---ADQEL-----DKELEKPLGE 216
gi 341890233 115 PGDAr--tAQDQADLRKQAILESKYLGGDLEHTHLVKGLDYSLLNKVRSEMTAEDEE---DDEDM-----EALETKAAAK 184
gi 356556428  55 APPGt--vDIRSSDAHKLSIEKSKYLGGDVEHTHLVKGLDYALLNKVRSEIDKKPET---GDDVE--------------- 114
gi 586695718  55 APPGt--vDLRIADAHKISIENSKYLGGDLEHTHLVKGLDYALLHKVRSEIDKKPEQ---EEEVD--------------- 114
gi 357157713  60 APPGapgaDLRLADAQKISIEKSKYLGGDLEHTHLVKGLDFALLNKVRSEIDKKPDA---EDGKD--------------- 121
gi 302840939 102 GGDAg--gDLGTVDLSKLSEEETKYLGGDMRFTHLVKGLDYALLHKTRTEITKKKDDdgdGDDDEgraggGADAGSKAEA 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74799447  203 EasipapgNTlppqrasvagSVDKEPQ----DELEFRTVLGQNIFRtlEKQR--SRKIERNEMFAPGRMAYHIELEDE-N 275
gi 75219484  115 --------GK----------TSAPKED----QRVTFRTIAAKSVYQw-IVKP--QTIIKSNEMFLPGRMTFVYDMEGG-- 167
gi 75023280  191 KpseasllAQ----------ELAQSHS---------ENRMVRSLHR--VLFK--NEVPLHNQLFAKGRMAYVVELEDE-- 245
gi 358337845 219 --------------------KDRLTTE----DGVQFRTKLAAGIFD--ALFN--LRPPERNEYFQPGRMAYRIELEDD-S 269
gi 674586127 217 D-------II----------RREGTLE----TGLNFKTRMAEKIIE--TLFKsnQGNVERNEYFQPGRMAYRVELEDE-M 272
gi 341890233 185 P-------SE----------ASSLTQEl---AQSQSDNRMVRSLHR--VLFK--NEIPLRNDMFAKGRMAYVVELEEE-- 238
gi 356556428 115 --------GK----------SRSAKED----QQVSIRTATAKSVYQw-IVKP--QTISKTNEMFLPGRMTFIYNMEGG-- 167
gi 586695718 115 --------GK----------TRGSKDD----QPLSFRTATAKSVYEw-IVKP--QTVVKTNEMFLPGRMAFVFDMEED-- 167
gi 357157713 122 --------AK----------ARETKED----RAISFRTAIAKSVYQs-IVKS--QSTPKANEMFLPGRMAFIYNMEDG-L 175
gi 302840939 180 ArdaqaraNA----------RANAASAagrkEEVRFTAPLARSVFN--TLFS--APRANVREMYLPRRTAFVYDFDNEdS 245
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74799447  276 VDSDIPTTVIRSKAEVPlEVG--DTQT----LTTNDIVINKLAQILSYMRQGGR-GKKNK 328
gi 75219484  168 YTHDIPTTLYRSKADCP-VPE--EFVT----VNVDGSVLDRIAKIMSYLRLGSS-GKVLK 219
gi 75023280  246 -ETDIPTTLLRSLHDLP-RAE--SAQS----IQANNLIILKLSHVLSHLRAEPKkkkkee 297
gi 358337845 270 VDFEVPATVIRSKADCL-QTDgrGSDT----ITTNEIVINKLTQILSYLRAGKRhAKKAK 324
gi 674586127 273 AEFEVPATVIRSKADCP-LLD--ETTSsnsnLSTDDIIINKLAQIFAYTRAGRRqAKKAK 329
gi 341890233 239 -DTDIPTTLLRSLHDLP-RAE--SAQS----IQANSLIISKLAHVLSHLRAEPK-KKKKd 289
gi 356556428 168 YHHDIPTTLHRSKADCP-VPE--EMVT----VNVDGSVLDRIAKIMSYLRLGSS-GKILK 219
gi 586695718 168 YAHDIPTTVHRSKADCP-VPQ--EMVT----VSVDGSVLDRIAKIMSYLRLGSS-GKVLK 219
gi 357157713 176 ITNDIPTTLHRSKADCP-VPE--EMVT----VSVDGSVLDRIAKIMSYLRLGSS-GKVLK 227
gi 302840939 246 LDTDIPTTLRRPKSECPpAVE---TLF----AGMDDAVLDRIARILSYVRTTAD-GKRLK 297
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