Conserved Protein Domain Family
RED_N

?
pfam07808: RED_N 
RED-like protein N-terminal region
This family contains sequences that are similar to the N-terminal region of Red protein. This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region, suggesting that these proteins are expressed in the nucleus. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated of that the protein self-aggregates extremely efficiently.
Statistics
?
PSSM-Id: 336817
View PSSM: pfam07808
Aligned: 30 rows
Threshold Bit Score: 139.738
Threshold Setting Gi: 74866287
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74799447    86 QLKKQED-NKLAELAEKYRDRARERRDGA--------------------N-----------PDY-QNLDSSSSTSAYRAV 132
gi 75219484    12 TARRREE-KLEESDNPKYRDRAKERRENQ--------------------N-----------PDY-DP----SELSSFHAV 54
gi 75023280    72 TEADEDE-AALKNILKNYRDRAAERRKQG--------------------D---------------EKEDPSKLTAAYRAV 115
gi 1084309254  94 skKDTQK-PDISESTHRYRDRAKERRDGK--------------------LvapteeveeerEIE-NDDDTLTRTADYRAV 151
gi 358337845   91 hrRDQAK-ESAAEPTPRYRDRAKERRDGK--------------------Lvapse-egadeRDYeQDEEALSRTADYRAV 148
gi 674586127   82 EDGDGDE-SRKSDKAPKYRDRARERREGKissnmesldstiheeavearD-----------DEE-EDPNRLIHTADYRAV 148
gi 341890233   71 TEADEDE-AHLKNILKNYRDRAAERRKQG--------------------D---------------EKEDTTKLTAAYRAV 114
gi 356556428   13 PIRRKEE-KPEEPEVPKYRDRAKERREDQ--------------------N-----------PDY-EQ----TELG-FHAV 54
gi 586695718   12 MARRKEE-KQDEPELPKYRDRAKERREDQ--------------------N-----------PDY-EP----TELGSFHAV 54
gi 357157713   16 MARRKEEnKKEEPETPRYRDRAKERREDQ--------------------N-----------PDY-EP----TELGSFHAV 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74799447   133 APDVk--sGLNAAERRRQQIQESKFLGGDMEHTHLVKGLDYALLQKVRSEIVAKENEQEEEM-----EKLVDIEPSAEas 205
gi 75219484    55 APPGa--vDIRAADALKISIENSKYLGGDVEHTHLVKGLDYALLNKVRSEIVKKPDGEDGDG------------------ 114
gi 75023280   116 PGDAr--sAQDQADLRKQAILESKYLGGDLEHTHLVKGLDYSLLNKVRSEIDKSDDDDDDDIdtafdEKVTSSSSSSKps 193
gi 1084309254 152 APSSa--aGASHAERRRMLIQESKYLGGDMEHTHLVKGLDYVLLQKVRLEIQNKEIEAEQAL-----DIELNKP---D-- 219
gi 358337845  149 APTSa--aGQSLAERRRMLIQESKYLGGDMEHTHLVKGLDYVLLQKVRLEIQNKELEAEKVL-----DAELSKPEVS--- 218
gi 674586127  149 APTt----GADHAAERMRAIEESKYLGGDMENTHLVKGLDYALLKKMRRQIRSMELQADQEL-----DKELEKPLGED-- 217
gi 341890233  115 PGDAr--tAQDQADLRKQAILESKYLGGDLEHTHLVKGLDYSLLNKVRSEMTAEDEEDDEDM-----EALETKAAAKP-- 185
gi 356556428   55 APPGt--vDIRSSDAHKLSIEKSKYLGGDVEHTHLVKGLDYALLNKVRSEIDKKPETGDDVE------------------ 114
gi 586695718   55 APPGt--vDLRIADAHKISIENSKYLGGDLEHTHLVKGLDYALLHKVRSEIDKKPEQEEEVD------------------ 114
gi 357157713   60 APPGapgaDLRLADAQKISIEKSKYLGGDLEHTHLVKGLDFALLNKVRSEIDKKPDAEDGKD------------------ 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74799447   206 ipapgNTlppqrasvagSVDKEPQ-DELEFRTVLGQNIFRtlEKQR--SRKIERNEMFAPGRMAYHIELEDENVDSDIPT 282
gi 75219484   115 -----GK----------TSAPKED-QRVTFRTIAAKSVYQw-IVKP--QTIIKSNEMFLPGRMTFVYDMEGG-YTHDIPT 174
gi 75023280   194 easllAQ----------ELAQSHS------ENRMVRSLHR--VLFK--NEVPLHNQLFAKGRMAYVVELEDE--ETDIPT 251
gi 1084309254 220 -----RM----------KESANNE-EGIQFRTHLAANICN--VIFN--ERLPERNEYFQPGRMAYRIELEDDSVDFEVPA 279
gi 358337845  219 -----------------KDRLTTE-DGVQFRTKLAAGIFD--ALFN--LRPPERNEYFQPGRMAYRIELEDDSVDFEVPA 276
gi 674586127  218 -----II----------RREGTLE-TGLNFKTRMAEKIIE--TLFKsnQGNVERNEYFQPGRMAYRVELEDEMAEFEVPA 279
gi 341890233  186 -----SE----------ASSLTQElAQSQSDNRMVRSLHR--VLFK--NEIPLRNDMFAKGRMAYVVELEEE--DTDIPT 244
gi 356556428  115 -----GK----------SRSAKED-QQVSIRTATAKSVYQw-IVKP--QTISKTNEMFLPGRMTFIYNMEGG-YHHDIPT 174
gi 586695718  115 -----GK----------TRGSKDD-QPLSFRTATAKSVYEw-IVKP--QTVVKTNEMFLPGRMAFVFDMEED-YAHDIPT 174
gi 357157713  122 -----AK----------ARETKED-RAISFRTAIAKSVYQs-IVKS--QSTPKANEMFLPGRMAFIYNMEDGLITNDIPT 182
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 74799447   283 TVIRSKAEVPlEVG--DTQT----LTTNDIVINKLAQILSYMRQGGR-GKKNK 328
gi 75219484   175 TLYRSKADCP-VPE--EFVT----VNVDGSVLDRIAKIMSYLRLGSS-GKVLK 219
gi 75023280   252 TLLRSLHDLP-RAE--SAQS----IQANNLIILKLSHVLSHLRAEPKkkkkee 297
gi 1084309254 280 TVIRSKSDCL-QIDgrGTGA----ITTNEIVINKLTQILSYLRAGKRhAKKAK 327
gi 358337845  277 TVIRSKADCL-QTDgrGSDT----ITTNEIVINKLTQILSYLRAGKRhAKKAK 324
gi 674586127  280 TVIRSKADCP-LLD--ETTSsnsnLSTDDIIINKLAQIFAYTRAGRRqAKKAK 329
gi 341890233  245 TLLRSLHDLP-RAE--SAQS----IQANSLIISKLAHVLSHLRAEPK-KKKKd 289
gi 356556428  175 TLHRSKADCP-VPE--EMVT----VNVDGSVLDRIAKIMSYLRLGSS-GKILK 219
gi 586695718  175 TVHRSKADCP-VPQ--EMVT----VSVDGSVLDRIAKIMSYLRLGSS-GKVLK 219
gi 357157713  183 TLHRSKADCP-VPE--EMVT----VSVDGSVLDRIAKIMSYLRLGSS-GKVLK 227
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap