Conserved Protein Domain Family
Abi_HHR

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pfam07815: Abi_HHR 
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Abl-interactor HHR
The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganisation, but their precise role remains unclear.
Statistics
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PSSM-Id: 311662
View PSSM: pfam07815
Aligned: 25 rows
Threshold Bit Score: 100.443
Threshold Setting Gi: 0
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4N78_F         94 ISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANL-ERPVRYIRKPIDYTILDDIGHGVKWlL--RFKVSTQNMKMG 170
18_pfamImport   1 IGQTIEMHKEKVARREIGAFTAVRRVPRNHKIIPPTGT-QPRPSYSRRPINYQQLDEIGHGIKV-S------GKQPEKTG 72
23_pfamImport   1 ISQTVDMHREKVSRREIGVFTTVKRMPRNQKIIPPPATpEQKTKYSRTPIAYATLDSVGHGMKD-S------SKQLGRTG 73
7_pfamImport    1 IGQTVDMHREKVARREIGAFTVGKRVPRNHKVVPPAKNkEAKLKYTRTPISFSSLDSVGHGVKD-SgqPQLKTATMSRSG 79
15_pfamImport   1 -SLAVAIHFEKVSRREIGAFTTPKTRIRVKHVTPPASGkEPLRSYSRVPISYCTLDSIGHCFQQ-L--------ETEREA 70
6_pfamImport    1 -TLTVAMYKEKIARGEIGVLTKQAKVPRTQKVVPPAKGlEPFRGYRRVPISYSCLDKLGHGHWQ-GnkTEETKTESDYED 78
8_pfamImport    1 LSQMVNMHMEKVARREIGTLATVMRLPPSQKVIPPESL-PPLTPYYRKPLNFSCLDDIGHGIKD-L------STQLSRTG 72
10_pfamImport   1 LGQMVDMHLEKVARREIGTLAAVQRLYPGQKVIAPSSL-PPLEPYCRRPINFGCLDDIGHGVKD-L------STQLSRTG 72
4_pfamImport    1 VAQCVDMHKEKVSRREIGSLTVSKRFPSHQKITSPPNP-PSLEPYYRKPLNFSILDDIGHGIKD-H------STQLSRTG 72
21_pfamImport   1 IEQVIEMHKEKVSRREIGMLTVCKTFPPYQKIIYPKKL-EPLQPYYRKPLDFSTLDDIGHGIKD-Q------STQLAKTG 72
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