Conserved Protein Domain Family
GLE1

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pfam07817: GLE1 
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GLE1-like protein
The members of this family are sequences that are similar to the human protein GLE1. This protein is localized at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm.
Statistics
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PSSM-Id: 311664
View PSSM: pfam07817
Aligned: 84 rows
Threshold Bit Score: 177.798
Threshold Setting Gi: 358335612
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RRM_B        17 DKIAQIKQDIVLPIK-KaDVNVRNLLSRHKRKINPKFGQLTN-SN-QQLFKIQNELTQLI--------ND-------TKg 78
gi 74867210  384 QSKVDAVKPLQT------EESLKQYRTGCQRAINLPLNAISA-VSpQHLAQNFDKLYSFF---------A-------GQp 440
gi 122093904 375 EQHQTAVKALLD------DPSMKTYRFNCSKVINTPVNTISA-VSrEHFVDKFNKLDAFL---------S-------GQp 431
gi 158300671 317 ksfyeqhqtaVKQLM-D-DPSMKTYRFNCQKAINVPVNAISA-VNrEHFIDKYSKLAALL---------S-------GQn 377
gi 195028730 369 ialyQGKVDAVKPLQ-T-DEAWKKYRTNCQRTINVPLNAITAaSA-QHLTTNFDKLYNFF---------A-------GQp 429
gi 328724042 388 KKIKKSYSSFLE------NDNLKPLRQELVKAINTPVNSISSvSS-WHMKDKFEKLDALLkcktvktgNS-------TVt 453
gi 985394130 298 kvlinnltsvrelpfvN-DPTTKVFRQNVIKVINTLVNTIST-TNvTHLTDKYNKLNALL--------SGklvcvanTQv 367
gi 330792554 466 DMIKQIEQYLLSVKPtQ-SKENLDYEKQLTKNINIAINQISA-SK-EQTESKAKRLTDIL--------Gnek-------- 526
gi 195382302 381 qgkVDAVKPLQT------DDTWKKYRTNCQRTINLPLNAITA-TSaQHLTNNFDKLYNFF---------A-------GQp 437
gi 170057741 310 EQTQLKIQPLAD------DPSLFVYRKNLGTVVNVAVSTMSG-SC-AWIEAQFNLLHALL---------G-------GAr 365
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RRM_B        79 ---------------DSLAYHWILNFIAKAVVRQAETEVRVKPESALPLGKLTLYLLVQFPELQELFMARLVKKCPFVIG 143
gi 74867210  441 tkvmng--titindhPLA-RDYCMLLMAKKFVSQTETAICSNPQAAFPFASVIITFWKLLPDFGKVFLAYMYKESPFLVP 517
gi 122093904 432 aktgdv--svsinghPLG-RTYCMMLMAKKFVGHADSMISSNAPAAFPFAAIIVALWQKYPEFGKFFLAYLHKECPYLVP 508
gi 158300671 378 vkagdg---mvsingHPLGRTYCTMLLAKKFVSQADTSISSNASAAFPVAAIAVALWQRFPDFGRFFLAYLHRECPYLVP 454
gi 195028730 430 vrttdg--ttitindHPLARDYCILLMAKKFVSQTDTAISSNPQAAFPFASVIVTFWRLLPDFGKIFLAYMYKESPYLVP 507
gi 328724042 454 an-----------shPD-ALIFCKDTLAKKIINIGEQVASVKTETAFEVASIVTELWKIHPDFGILLYARFKQICPCLIP 521
gi 985394130 368 mv-----------geNKEALAFCMETLATKIVNYAEEVICVKTQAAYEIATIITKLWNVHQQFGKILFAVMKQKCPLLVP 436
gi 330792554 527 -------------rnNEYFYKRALISIANKSMDQVESQITFHTASAFPLSDVLIKVGKQFPELFKIILGKLEEHCMYTVP 593
gi 195382302 438 vrttdgs-titindhPLA-RDYCILLMAKKFVSQTDTAISSNPQAAFPFASVIVTFWKLLPDFGRIFLAYMYKESPYLVP 515
gi 170057741 366 vavansgtfvttegyPEA-RAYCASMLAEKYVHQADLLISNNPPCAFPIASVIVALWQKYPDFGRLFLAVLFRECPFLAP 444
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RRM_B       144 F----T----C-EIDTEKGRQNM---GWKRnNENK--WEDNTSYDERMGGILSLFAIITRLQLpQEf------------I 197
gi 74867210  518 YvipqQ----Q-GQTPEQYLKTI---GYRLtDKNE--LEKPDIYLKRQTGLARLYAAVIISQGrKA-------------- 573
gi 122093904 509 FflpqL----E-GQTQEDYLKSI---GYRF-TDNV--LEKQDQYLKRVTGFARLYAAVVVTNPrRG-------------- 563
gi 158300671 455 YylpqH----E-GQSQEEFLKTL---GYRFaDGGV--LEKQDQYLKRMSGLARLYAAVIVTVPrKD-------------D 511
gi 195028730 508 YvipqQ----S-GQTPEQYLKTM---GYRLsENNE--LEKPDMFLKRQTGIARLYAAVIITPGrKA-------------- 563
gi 328724042 522 YnaekT----N-EETDEEYYKSL---CYNYt-NGV--VEKQDKYVKRMTGIVRLFAAIIVTESkSG-------------K 577
gi 985394130 437 FyhpiAkhliC-EQLD---HKSF---GYKFdSLGN--VESDAKYLQRMTGIIRLYASLIVT----S-------------S 490
gi 330792554 594 Mys--------tlIQGEDKNISLqkaGYLFnEETKkpAETDEEFNKRMCGYISLFTSLILKSEqPStatmfgfgsaataS 665
gi 195382302 516 YvipqQ----A-DQTPQQYLKTM---GYRLsENNE--LEKPDMFLKRQTGIARLYAAVIITPGrKA-------------- 571
gi 170057741 445 FyparS----EpDQDQADYRRSL---GYRFgPDGT--PERQIVYLKRMAALARLYGAIVASNLrKG-------------T 502
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
3RRM_B       198 TTTSHpfpiAlsWHILARICNTPLNLITNTHFVILGSWWDAAAVQFLQAYGNQASKLLIL 257
gi 74867210  574 AGPDEcfelNegWLWLAHMVHV--KPLPDISATLIMEILQTLGFELWRTYGKQFVKLLVY 631
gi 122093904 564 ETAAHphglEcgWRWLCNILNL--SPLPDICATVITEFLQTAGASLWANYGKQFVKVLKV 621
gi 158300671 512 PT-PHphglEygWRWLTNILN--RFPQPDICATLIAEFLQTAGSELHAAYGKQFLKVLRV 568
gi 195028730 564 DGSAHcfglEeaWCWLTHIMNV--TPLPDICATMIMEMLQTLGFELWRAYGRNFLKLLLY 621
gi 328724042 578 Alg-----iGqaWMLIAATVHL--VPQLDVTAVFLHEILIITGYSLKQTYGRQFIKMLEY 630
gi 985394130 491 KCDQPviglShaWIFVAGTLNQ--NPVADITATLLVEFLKIVGFVMHQGYGNQFIKLLQh 548
gi 330792554 666 NAPNTlfnlDlaLKWLHGIVHLKP---RRITSYLLVAFLSQMGNILFK---KQKQNLFEI 719
gi 195382302 572 DGPAHcfglDeaWRWLTHIMHV--KPLPDICATMIMEMLQTLGFELWHAYGVNFLKLLVY 629
gi 170057741 503 AGLPHphglEfgWRWICAVLNM--TPLADICATLLTEVLLMAGHRMWHCYGDQFVKVLRV 560
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