3RRM


Conserved Protein Domain Family
GLE1

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pfam07817: GLE1 
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GLE1-like protein
The members of this family are sequences that are similar to the human protein GLE1. This protein is localized at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm.
Statistics
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PSSM-Id: 336823
View PSSM: pfam07817
Aligned: 83 rows
Threshold Bit Score: 178.175
Threshold Setting Gi: 358335612
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RRM_B         17 DKIAQIKQDIVLPIK------Ka------DVNVRNLLSRHKRKINPKFGQLTN-SN-Q-QLFKIQNELTQLIN------D 75
gi 91087075   314 KKYAEIKQFLSNHSQlykdllA-------EEQLKQFRFDCKKAINIPVNALSA-VN-SdHLRDKYVKLNNLL-------S 377
gi 965561499  341 tnylieieakLKPFL------S-------DESLKKYRSDCQKAVNLPVNAISPvSA-A-HLMDKLKKLSTLLQ------G 399
gi 328724042  388 KKIKKSYSSFLE-----------------NDNLKPLRQELVKAINTPVNSISSvSS-W-HMKDKFEKLDALLKcktvktG 448
gi 1133475210 361 yeelieklekantqtatfsktS-------DPQMKKYKFSLQKAVNM-VGAVSG-QTgS-QLLHIVQQIKRLLSgdiievS 430
gi 985394130  293 lvknnkvlinnltsvrelpfvN-------DPTTKVFRQNVIKVINTLVNTIST-TNvT-HLTDKYNKLNALL-------S 356
gi 302755070  425 KKILQQLNEASKSLQ------A-------NPVLRKNLKALGFQIGKLWNQVAA-TE-E-QVRKVSMEFLQLan------- 481
gi 330792554  466 DMIKQIEQYLLSVKPt-----Q-------SKENLDYEKQLTKNINIAINQISA-SK-E-QTESKAKRLTDILG------N 524
gi 357630900   19 DKYENSYKDLLQ-----------------DNNCKKFRFDCQKAVNTPVNALSS-VSgV-HMRDKFDKLSKLL-------K 72
gi 571490412  346 NALNLEQWRLQKLKE------LcegnqmiRSSYNEDCTRHEGRISRNIRQIRG-IS-D-NVRSKASELTKLLs------- 409
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RRM_B         76 T------Kg-------------DSLAYHWILNFIAKAVVRQAETEVRVKPESALPLGKLTLYLLVQFPELQELFMARLVK 136
gi 91087075   378 G------KtvivadrqvnalkhPQGI-PFCMDLLARKFVLQGDLMISSNPEAAFCYATIIVSLWNDFPDFGKLLLGYFYT 450
gi 965561499  400 QyvtvadKrvsa-------sahPLGLF-YCMNLLAEKIVKQGEQVVSSKPHAAFAIAAVTVALWIDFPDFGKLLLAHFYR 471
gi 328724042  449 N------Stvta-------nshPD-ALIFCKDTLAKKIINIGEQVASVKTETAFEVASIVTELWKIHPDFGILLYARFKQ 514
gi 1133475210 431 G------Krvtv-------kdhP-LARDYCINLLARKIVEQAGEASRF----VFTLAGIVVLLWHNFPEFGDLFLAHCYH 492
gi 985394130  357 G------Klvcvant-qvmvgeNKEALAFCMETLATKIVNYAEEVICVKTQAAYEIATIITKLWNVHQQFGKILFAVMKQ 429
gi 302755070  482 ---------------------nPQS-QPFVVSTLASKLMSQCEAQVLRAPSYAFVFARIVVNVSSQLPVVMDAVLAHLNV 539
gi 330792554  525 E------Kr------------nNEYFYKRALISIANKSMDQVESQITFHTASAFPLSDVLIKVGKQFPELFKIILGKLEE 586
gi 357630900   73 G------ErvqvldtfvtatqhPQG-LPYCTALLAKKIVRQGDLLVSSNPDAAFPLAAVTVALWSQFPEFGKLLEAYFHR 145
gi 571490412  410 ---------------------hPQSFQSISIEIFAKKVVAYCANPA----NVPFASAYVIVLVTSQVPHAMDILLAELHR 464
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RRM_B        137 KCPFVIGF-----T----C-EID------TEKGRQNM---GWKRnNENK--WEDNTSYDERMGGILSLFAIITRL-QLpQ 194
gi 91087075   451 ECPYLVPFyi-pkT----E-EQT------TEEYYQVL---GYHYi-DGQ--IEKQDKFLKRMTGILRLYFAIFIA-KPkR 511
gi 965561499  472 KCPYLIPAyw-erE----E-NES------EEEYYRKL---GFSY-SGGT--MEEANMFLKRQGGIVKLYSSIIIT-ERkK 532
gi 328724042  515 ICPCLIPYna-ekT----N-EET------DEEYYKSL---CYNYt-NGV--VEKQDKYVKRMTGIVRLFAAIIVT-ESkS 575
gi 1133475210 493 TCPVLVPLyf-rkN----K-GMS------EIEFKKLL---GYKV-VGGI--LEEDKLFNDRLSGCVKLYAAVIQT-TP-- 551
gi 985394130  430 KCPLLVPFyh-piAkhliC-EQL------D---HKSF---GYKFdSLGN--VESDAKYLQRMTGIIRLYASLIVT----- 488
gi 302755070  540 VCILTVPKyf-myK----KvTFSsfffpcDKSYYNML---GFREdDSGT--LETADDYVARMTAYVTLYAAITQT----- 604
gi 330792554  587 HCMYTVPMys---------tlIQ------GEDKNISLqkaGYLFnEETKkpAETDEEFNKRMCGYISLFTSLILK-SEqP 650
gi 357630900  146 FCPYLVPMll-pqK----E-GQT------DKEFYISR---GYTYnDEDV--VEKQDKFLRRMSGIFRLRCAMWITsTPr- 207
gi 571490412  465 ACIYTVPKhlvykK----SaYQS------KEAYFRSI---GYRe-DDEK--MESTEDYLKRLESYMKMYGALVQT----- 523
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
3RRM_B        195 Ef------------ITTTSHpfpiAlsWHILARICNTPLNLITNTHFVILGSWWDAAAVQFLQAYGNQASKLLIL 257
gi 91087075   512 G-------------QTKNPYd--iTnaWIFLASILKL--KPQLDITATVLHVFLETVGFEMELVYGMAFKKLVVI 569
gi 965561499  533 S-------------MQSHNHpvglGecWRLLVAFVKLEPKP--EISATVLYDILDITGDAMVRAYGIQFHKLLHV 592
gi 328724042  576 G-------------KAlg-----iGqaWMLIAATVHL--VPQLDVTAVFLHEILIITGYSLKQTYGRQFIKMLEY 630
gi 1133475210 552 --------------IMGVPNhhglDngWTLIARLLNS--EPQHNITAIALKSLLEVAGHGLMKKYGRQFKKIvlf 610
gi 985394130  489 S-------------SKCDQPviglShaWIFVAGTLNQ--NPVADITATLLVEFLKIVGFVMHQGYGNQFIKLLQh 548
gi 302755070  605 ----------------GGTNghgiAngWKWCAQLLNH--LPANRYSASALFAFLETAGFRLYQSYPKPFMKLMNT 661
gi 330792554  651 StatmfgfgsaataSNAPNTlfnlDlaLKWLHGIVHLKP---RRITSYLLVAFLSQMGNILFK---KQKQNLFEI 719
gi 357630900  208 --------------FLNVSNpngmGfsWRWLASFINL--KPEPDISATLLHDFFIVCGSQFLKLYGKQCVKIIKL 266
gi 571490412  524 E-------------ITNCQNfhglKegWAWLARFLNT--HPANQYTAVSLNAFLQMAGFALYNRYKSQFLKMLNV 583
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