Conserved Protein Domain Family
Exc

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pfam07825: Exc 
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Excisionase-like protein
The phage-encoded excisionase protein (Xis) is involved in excisive recombination by regulating the assembly of the excisive intasome and by inhibiting viral integration. It adopts an unusual 'winged'-helix structure in which two alpha helices are packed against two extended strands. Also present in the structure is a two-stranded anti-parallel beta-sheet, whose strands are connected by a four-residue 'wing'. During interaction with DNA, helix alpha2 is thought to insert into the major groove, while the wing contacts the adjacent minor groove or phosphodiester backbone. The C-terminal region of Xis is involved in interaction with phage-encoded integrase (Int), and a putative C-terminal alpha helix may fold upon interaction with Int and/or DNA.
Statistics
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PSSM-Id: 116439
View PSSM: pfam07825
Aligned: 3 rows
Threshold Bit Score: 118.598
Threshold Setting Gi: 81586350
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1PM6_A       1 MYLTLQEWNARQ-RRPRSLETVRRWVRESRIFPPPVKDGREYLFHESAVKVDLNR----PVTGSLLKRIRNGKKAKS 72
gi 139680    1 MYLTLQEWNARQ-RRPRSLETVRRWVRECRIFPPPVKDGREYLFHESAVKVDLNR----PVTGGLLKRIRNGKKAKS 72
gi 81586350  2 CKVTLDEWAHDHfRTPPSSNTLRRWAREGLITPAPVKHGRSYYVEADACYREPEPlprvPVGSPLVNRIASARYGAQ 78
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