2NTK


Conserved Protein Domain Family
IMP_cyclohyd

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pfam07826: IMP_cyclohyd 
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IMP cyclohydrolase-like protein
This enzyme may catalyze the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to inosine monophosphate (IMP), a reaction which is important in de novo purine biosynthesis in archaeal species. This single domain protein is arranged to form an overall fold that consists of a four-layered alpha-beta-beta-alpha core structure. The two antiparallel beta-sheets pack against each other and are covered by alpha-helices on one face of the molecule. The protein is structurally similar to members of the N-terminal nucleophile (NTN) hydrolase superfamily. A deep pocket was in fact found on the surface of IMP cyclohydrolase in a position equivalent to that of active sites of NTN-hydrolases, but an N-terminal nucleophile could not be found. Therefore, it is thought that this enzyme is structurally but not functionally similar to members of the NTN-hydrolase family.
Statistics
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PSSM-Id: 336827
View PSSM: pfam07826
Aligned: 65 rows
Threshold Bit Score: 206.259
Threshold Setting Gi: 503234438
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2NTK_A        22 YLGRILAVGRNsNGS-FVAYRVSSRSFPNRTTSI-Q-EERVAVVpveghERDVFRNPYIAYNCIRIV-G-DTAVVSNGSH 96
gi 74502088    3 YVGRTLGIGLN-NGKpFAFYLLCSRSFPNRRAVV-K-GNGVYIL-----NQTETENPYVSYPVVRLM-E-DYAVVTNGLH 72
gi 74516890    2 YVGRFVVVSPE-----VGAYRVSSRSFPNRQAVQ-R-DGTVTVEptpdaPET--DNPYISYNGVRVT-E-RGAVVGNGSH 70
gi 121724521   2 YVGRFIVVAPD-----RAAYRVSSRSFPNRRIVD-R-DGTLTVGptedaPET--DNPYISYNCLRTVgD-DYAVVGNGTQ 71
gi 121693603   2 YVGRIVAVGCSgDAV-WVGYRVSSRSFPNRRATA-S-GSSVFVHpv--dPSDVLKNPYITYPCIRAS-N-DFAVVSNGDH 74
gi 121688076   2 YVGRFVTIGKTnGRL-WAGYRVSSRSFPNRYAVK-LgDDKVAIMpk--dVKDLEKSPYISYNCIRVL-P-SVAVVTNGSH 75
gi 282157599   2 YVGRFVCVGKT-NGKlWAGYRVSSRSFPNRYAVKlS-DSTVAIMpk--dVKDLEKSPYISYNCIRLA-D-GAAVVSNGSH 75
gi 503818662   2 YVGRFLVVAPG-----LAGYRVSSRSFPNRKAVE-R-DGAVTVLpt--aEAEPTDNPYVSYNCVQEV-DaTTAVIGNGSH 71
gi 492947527   2 YVGRFIVIGPD-----FGAYRVSSRSFPNRQVVE-R-DGTLTVAptpdaPET--DNPYISYNCVREG-G-DSVVVGNGSH 70
gi 490168955   3 YVGRMLGVGLK-DGKpFAFYRLNSRSFPDRKAVI-K-GDEVYIV-----NLTETENPYVSYPVVKIL-P-DYAVVSNGSH 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2NTK_A        97 TDTIADKVALGMNlRDAiglsLLAMDYEKDELNTPRIAAAINgs-----------eAFIGIVTADGLMVSRVP--EET-P 162
gi 74502088   73 TDFIAQALEWERP-RKAlvhvLDALDYERDDYSTPRIAGIIQhgg---------rrGWLGFVGRDMLWMRELEleEGK-A 141
gi 74516890   71 VDPIAEKLELGYPaRDAiaepLLSLDFEKDDYDTPRVAGIVGvdaadpttnadgpgAVIGTVRRDALLVEEVT----E-P 145
gi 121724521  72 VDPIAEKLSLGYPpRDAlaesLLALDYEKDDYDTPRIAGVVGd------------eSYIGTVRRDALIVEAVE----E-P 134
gi 121693603  75 TDMIFDRIEDGSGpLDAvalsLVAYGYERDDLRTPRIAGVVSgr-----------sAVLGIAAHDEIRVRKIElqDGD-A 142
gi 121688076  76 TDAIVEKIEMGYPiRDAlalsLLAMDYEKDSLDTPRIAAVVSrh-----------vAYLGIVTKDGLNVSTFPmgDNE-C 143
gi 282157599  76 TDPIAEKIARGYPaRDAialsLLAMDYEKDSLNTPRIAAVLSnd-----------mAYLGIVTKDGINVSDFPlmENE-C 143
gi 503818662  72 VDPIAEKLGLGYPaRDAlalsLLALDFEKDDYDTPRIAAVVGae-----------sAFIGTVRRDALLIQEVD----E-P 135
gi 492947527  71 VDPIAEKLDLGYPaRDAlaesLLAMDYEKDDYDTPRIAGVVGe------------eSYIGIVRRDALLVRPVT----EnP 134
gi 490168955  73 TTFIAQALEWESP-KKAlihvLDAMDYERDEYNTPRIAAIIQrdk---------dwAFLGFAGKDEFWVKRVTleEGR-T 141
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
2NTK_A       163 VYISTYEQTEPAATEF-KAG--SPEEAAEFilkggefAAFTHPVTAAAAFNDGEG 214
gi 74502088  142 FLTATYNMEGFESIEL-AFS--TPEELAEKvm----eLPFEHKVLAIGIVENEKG 189
gi 74516890  146 TLVATYEENSPTAFDL-AAT--DASDVAREvy----dHEYEHAVCSAGVAGSAGE 193
gi 121724521 135 TLVATYEKSEPEPTSL-GAD--DPSELAAEly----dRDLEHPVCAAGVVADGDS 182
gi 121693603 143 WMVATYEKTGFEPVSM-EGA--SASSIARSlf----gLPFERPVCSAAAFRRDDG 190
gi 121688076 144 LMVATYEKTMFSRLTV-DAS--SAEEVARKmy----dLTFEKPVCAAGAYQVDDH 191
gi 282157599 144 YMVATYEKTAFSRLTV-EAD--SAKDAAKKmf----dLTFEKPVCSAGAFQTDGG 191
gi 503818662 136 TLVATYEaDSPEPFPF-DSEpaDAAGIARAly----eHEYEHAVCAAGVTVDSDG 185
gi 492947527 135 MLVATYEEDDPAVVVFdGDG--SPAELAERay----eMDYEHAVCAAGVTYDDGD 183
gi 490168955 142 FFIATYNVYGIETLSL-DFK--DEKDLAEKvl----rLEFAHPVLAIGVVDGGDK 189
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