Conserved Protein Domain Family
Cu_amine_oxidN1

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pfam07833: Cu_amine_oxidN1 
Copper amine oxidase N-terminal domain
Copper amine oxidases catalyze the oxidative deamination of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other.
Statistics
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PSSM-Id: 311673
View PSSM: pfam07833
Aligned: 116 rows
Threshold Bit Score: 46.8183
Threshold Setting Gi: 0
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123766735   57 MGNRTYVPLRIISEKLGARVDW-QQDANRVIITTRETPSVPP-PADDRKNQGevqiiidG-------KILQLP----PSL 123
51_pfamImport   1 YKGKIMVPLNITAESLGFKVEA-DNDNKTVRLDNGKTKINLY-VGTDEYFYS-------SndpdtmvLEIMHKl--gAET 69
71_pfamImport   1 KDYVLMVPLKTAAEILGYKVGW-NSKKGASVA---GGYIKNN-V-DTYYTTG-------S-------RKIKL-----TPA 55
gi 123752919   62 SDGVLMVPLRRLADELGFTVQWqEGPPQSIVVNSGNLRAEMY-PGTWVVFLT-------Gsd----yRAVILPa--eVQQ 127
50_pfamImport   1 LNSVVMLSLNVLCQKLDTDAKL-EVKNDSALMNTSNYKVKIEnN-NKKISAN-------G-------KNITLT----TAP 60
gi 81480340    14 EDGKIFVPLWAIIEKLNGEIYW-NDLKKRINIRYNNTEIELQ-LGKNLYTKN-------E-------EIFSME----VFP 73
70_pfamImport   1 SDGTFMVPLEWFSETIGGEIAKiSVGSERVIY--GSNMAEIT-IGQTDYTKN-------Y-------EEKTMP----VAP 59
49_pfamImport   1 ENNNVYLPLKYVADSLGIKL-Y-NDEEYSVIIKVMDKNVKAN---KKGIFIE-------N-------SSTNLNtkidKNI 61
gi 81412092    21 KAFSAGVSVTDAAGRLDLDISW-DPLSQELIFIKNNSQVSCK-IGESLIIFD-------N-------EKADFT----PPP 80
gi 81344741    34 SADEAFVSAMKLARTLNVSVSW-NPLSQTILFSKGERRVQCR-VGQVLALLD-------G-------SEVLMI----DPP 93
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 123766735  124 -GrpyiTPaGRTVVPLRAVGEALGCEVNW-VAS-----TSTVEI 160
51_pfamImport  70 iK----VD-NVVYVPINLYNEIFN------NKKt----VGSFFV 98
71_pfamImport  56 kI----IG-NVMYVPVAYFSEVLKEDVSY-DGEgirlfTKSTVT 93
gi 123752919  128 kD-------GLIFVPTAFFQDAFRVPMAE-SKG-----EKGVYL 158
50_pfamImport  61 vI----KT-NIVFVPLEFFSEVFGKTINW-DNS-----TKSIEI 93
gi 81480340    74 -R----AEnNRTYVPLEFLIEGLGVKVNY-TIG-----EGKTVL 106
70_pfamImport  60 tQ----KN-NITMVPVDFISSIFPVNITN-DID-----RGTLKI 92
49_pfamImport  62 kV----RN-NELMLPQSYIKDIFEVNIEI-DNK-----TGEVI- 93
gi 81412092    81 yQ----KD-GLTFISGEMYKKLET--FFAvPQK-----EENYRV 112
gi 81344741    94 vV----KD-AVVYVSGGFAERLRK--VFGySSH-----QPEHRV 125
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