Conserved Protein Domain Family
FTCD_N

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pfam07837: FTCD_N 
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Formiminotransferase domain, N-terminal subdomain
The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains.
Statistics
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PSSM-Id: 311677
View PSSM: pfam07837
Aligned: 172 rows
Threshold Bit Score: 112.154
Threshold Setting Gi: 552842641
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QD1_A         6 CVPNFSEGKNQEVIDAISRAVAQt------P------GCVLLDVDSGPSTNRTVYTFVGRPEDVVEGALNAARAAYQLID 73
gi 163914889  13 CLLNVSEARKKYVVEKIARAALYdkngkmhP------NTAVLNIFSDYDYNRSVITIAATAEQIGKSVLSACIEGFASID 86
gi 556956705  13 CLLNISEARRKDIVEKVAKAAIQn------KhglrnlQATVLNIFSDFDYNRSVITIAAPIDEIGNSVVAACVEAFQSID 86
gi 410897499  13 CLLNVSEARKKDLVETVAKAAVYdtdgvrrD------GTTVLNIFNDRGYNRSVITIVASVDSIREAVLSACVKACGLID 86
gi 657588165  13 CLLNVSEARRKDLVETVAKAALYnaegvrrE------GTTVLNIFNDHDYNRSVITIVATIDSIREAILSACQEACGLID 86
gi 115497136  13 CLLNISEARRKDLVETVARSAITdikgekrE------GVTVLNIFNDSDYNRSVITVVANIELIREAVLSACECACSLID 86
gi 573897544  12 CLLNISEARSKEVVERVARAAVYekqggrrE------GITVLNIFSDHDYNRSVITIVATIDQIGGAIVSACVQACELID 85
gi 637343755  15 CLLNVSEGRRKDVVEKIAKAAVCkdkgqecL------QATVLNIFSDYEYNRSVITIAAPIDRLGSSVVAACMEAFSSID 88
gi 612020332  13 CLLNISEARRKNLVEKIAKAALFeengkeyS------EVTVLNIFSDHDYNRSVITIAATIEKLGSAVLATCVEAFQVID 86
gi 987961816  13 CLLNISEARRKHVVENIAKAALLgengkkrP------EVSVLNIFSDQDYNRSVITIAASVDELNHAVLAACVEAFRSID 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QD1_A        74 MSRHHGEHPRMGALDVCPFIPVRg-VTMDECVRCAQAFGQRLAEEL-GVPVYLYGEAARtaGRQSLPALRA--G--EYEA 147
gi 163914889  87 LAEHDGIHPCLGAIDLVPIYPLSg-VTLEKCGEVARDIAEGMATSIpGCSIFLFGYADLq-DQKSLAEKRRdlG--WFK- 161
gi 556956705  87 METHDGIHPCLGAVDLVPIHPLSqsVALEECGTVAQNIAETLAALVpGSSFFHFGYADQp-QMRSLVQRRKelG--WFR- 162
gi 410897499  87 MRAHSGIHPCMGAVDLVPIYPLGeeVGVEECAKEARALAQALTERVqGASAFLFGWADYp-LQRGLAQRRK--EmgWF-- 161
gi 657588165  87 MRTHTGVHPCMGAVDLVPIYPLGeeVGVEDCAKEARAVAQGLTETVpGTSAFLFGWADSp-LQRGLARRRK--DmgWF-- 161
gi 115497136  87 MSVHEGIHPCMGAVDLVPLYPLGedVGLQDCGEEAQALALTLAERVaGTSAFLFGWADSp-QHRGLAQRRK--EigWF-- 161
gi 573897544  86 MRRHSGAHPCLGAVDLVPIYPLGecVGLEECGQEARAVAVSLTERVpGTSVFHFGFADTp-QQRSLVQRRK--ElgWF-- 160
gi 637343755  89 MAAHVGIHPCLGAVDLVPIYPLSg-VDLEECGMVARNIAECLAHCVpGCSIFLFGHADLp-KKQSLVQRRK--QmgWF-N 163
gi 612020332  87 MEVQEGIHPCLGAVDLIPIYPLSe-VGVEECGMVARSLAEKLTIQVpGCSVFLFGEADQp-EKRSLVQRRK--ElgWF-- 160
gi 987961816  87 MEAQEGIHPCLGAVDLIPIYPLAg-VGVEECGAVARSLAETLVLRVpGSSVFLFGEADLp-KKRPLVQRRK--QlgWF-- 160
                        170       180       190
                 ....*....|....*....|....*....|..
1QD1_A       148 LPEKL-KqaeWAPDFGPSAFVPSWGATVAGAR 178
gi 163914889 162 NKTGI-DlnkLKADVG-AQPSRRYGITGVGAS 191
gi 556956705 163 KKSSL-NsneVKAG-GEATLSSKWGLTGIGAT 192
gi 410897499 162 QKSLDlQt--VRPDVG-PEPRRRFGVTGVGSs 190
gi 657588165 162 KKTPDlQe--IRPDMG-PQPQRRFGLTGVGAs 190
gi 115497136 162 RKVLNvSn--IKPDIG-SQPTRRYGITGVGAS 190
gi 573897544 161 RKNPDlRa--MQSDVG-AMPGKRYGLTGVGAS 189
gi 637343755 164 KGASKaAh--IIPDVG-LAPTSRYGLTGVGAS 192
gi 612020332 161 -SRREfSs--LKPDIG-TTPNKRCGLTGIGAS 188
gi 987961816 161 -ARRDlSa--LEPDLG-AAPARRCGLTGVGAS 188
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