Conserved Protein Domain Family
Renin_r

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pfam07850: Renin_r 
Renin receptor-like protein
The sequences featured in this family are similar to a region of the human renin receptor that bears a putative transmembrane spanning segment. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen cleavage by receptor-bound renin, therefore facilitating angiotensin II generation and action on a cell surface.
Statistics
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PSSM-Id: 311686
View PSSM: pfam07850
Aligned: 30 rows
Threshold Bit Score: 102.323
Threshold Setting Gi: 309366921
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122118499 228 AFDGAVVVGLITSTEAP-----------------L-----------------------------IRSKRQAAETEDDN-- 259
gi 75028203  216 AYGGQAVIELLAFEAESgaaekstesreipnhniQ-----------------------------KRDTKsktpt------ 260
gi 170578558 231 tYNDRVIAELITESKSEi---------------------------------------------kKRQKRQEDSPKSPSdr 265
gi 308505746 216 sYGGQAVVELLTFDAET-----------------Gsaeitsenre----------ipsdshniqKRDVSIGAFKDALNsa 268
gi 321461761 213 tYGDRFILTAITNERLr-----------------------------------------------LREKRSTTSNAKANsl 245
gi 309366921 109 AYGGHAVVELLNFKAED-----------------SsedvtssemwysefenpknpefienhkiqKREVSGIPGVREPTvy 171
gi 341896616 216 AYGGQAVVELLTFDAETgaeenaes-reipthniQ-----------------------------KRDVQykdvl------ 259
gi 512924399 246 AYDGSVLVTAVTTDi------------------vH-----------------------------TRRAIRSVSGNV---- 274
gi 91082273  238 VYKDKVLVSVITSDa------------------vH-----------------------------TRRARNILQEKKPEpk 270
gi 345486832 236 AYKNQVLIAVFTNDASQv---------------rH-----------------------------TRSLHERFERQAVMds 271
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 122118499 260 ---------PLNL-----ALKYDSNYPVIFNIILWFSVILVFSLLAISIAIATMDPGRDSIIYRMTStrmkkD 318
gi 75028203  261 ----qlareNLQV-----TVPVSSDYPAIFAIFLGLVVILVVALIYIVVGMASIDPEKDSIIYRMTTtrmkkD 324
gi 170578558 266 im---klrkELNV-----YQFSSGNYPATFGIFLLVSVALFLIVLFVTVGLWNMDPGKDSIIYRMVTtrmkkD 330
gi 308505746 269 -------rkGFQV-----TVPVSSDYPAIFAIFLGLVVILVIALIYIVVAMASIDPEKDSIIYRMTTtrmkkD 329
gi 321461761 246 re----lywKLNL-----SKRYGSDYSSIFNILLWTSVFLIAALISTAVFICTLDPGRDSIIYRMTTqrikke 309
gi 309366921 172 eqlrdaarkSYGV-----TEAVSSDYPAMFAMILGLVGALVVTTIYIIVAMVSIDPEKDSIIYRMTTdsqtsg 239
gi 341896616 260 ----kaarkSYQV-----AVPVSSDYPAIFAIFLGLVVILVVALIYIVVGMASIDPEKDSIIYRMTTtrmkkD 323
gi 512924399 275 -----------ELknsvdEDGYSADYAAIFNIILWFGVVFTFTLIAIVYALMDMDPGRDSIIYRMTNtrmkkD 336
gi 91082273  271 dt----qetKVNP-----AKFYSKDYPVIFNIILWFGVAMTFTLLAICIAIAQMDPGRDSIIYRMTStrlkkD 334
gi 345486832 272 ak----ndsQMNM-----AKNYQSEYSAIFNIILWFGVVFFFSLLAICITIAEMDPGRDSIIYRMTSnrmkkD 335
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