Conserved Protein Domain Family
N1221

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pfam07923: N1221 
N1221-like protein
The sequences featured in this family are similar to a hypothetical protein product of ORF N1221 in the CPT1-SPC98 intergenic region of the yeast genome. This encodes an acidic polypeptide with several possible transmembrane regions.
Statistics
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PSSM-Id: 336865
View PSSM: pfam07923
Aligned: 95 rows
Threshold Bit Score: 174.346
Threshold Setting Gi: 74581888
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74594254   127 PAYAFEYADCQPFPEELEEWFQYSefDr-AMILAMKS---SFERTWSLFcEvqpslssSTsWLDAPEAMQKLFLTEVLDN 202
gi 552936482   39 kEIAFIYADNDNLSSEIDEFYSYV--Ei-SQCIENKK---AFEEGFDE-----------S-WATCTISERRTYIEYLLET 100
gi 353236098   33 tfYDYHYDDEDSLFEEINEFYAFI--Ea-DQLAENLK---VWQGSFD-----------GD-WTKAPLQQRKTHVVALLED 94
gi 169860557   45 SWYDFKYDDEDTVMNEIEEFYSYI--Em-SQVAENLK---AWEGCFPSE------------WTKAPLNQRRSHAERLLEG 106
gi 170087030   20 SWYDFKYDDEDTVMNEIEEFYSYI--Em-PQVAENLK---AWEGSFTTE------------WTKAPIALRKSHIELLLES 81
gi 751837238   47 qRFDFRYEDEDTVFNEIDEFFSYV--Ev-PQYAENMR---AWQGSFNGE------------WTKSSVADRKAYVELLLES 108
gi 568452416   37 SWFDYKYDDEDTVMAEIEEFYSYV--Em-PQAVENLK---AWEDSY----M-------PE-WMKASPLERRTHVQLLLES 98
gi 685944514   25 tfLDFDYTDDDTLPNELNEFYSYV--DvrSVL-DNKH---EWQVGECGS------------WRDKPLDHRQSLIKDLLSA 86
gi 588261343   25 tfMDFKYNDDDNVMNEINEFYSYL--DvrCIL-DGKH---EWLDADYGS------------WWAMEDSQRRDLLAKLLNA 86
gi 634349834  234 ytfpspppDSSDIVSELQEFYSYV--EvpQVI-DHKDsflAWWDRPQQA------------FIDVPQTEQIELIHSLLDG 298
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74594254   203 LQdsellvRLEALESVCYVVTGVWGItagkstpdyphdspiaaenAKSKSLQIQWIVTNARLIHECSGLPSLYGCLLRAF 282
gi 552936482  101 LElkdpdkRFLTAKKLLYIAQGTFGE-------------------STSPEHHLELIVENNKLLRKCGALLSYFQALKLAC 161
gi 353236098   95 LEhkdsltRYNASRRLLYLLQGAFAE-------------------STSPEYQMHWIIENAKLVRASQGITIIVDALKMLS 155
gi 169860557  107 LEhrdaeiRFTNARRLFYVLQGTFAE-------------------TVSPEHQLHWIFENGKLVRSANGISNVVEALKIAG 167
gi 170087030   82 LEhrdaeiRFTNARRLFYVLQGTFSE-------------------TVSPEHQLHWIFENCKVVRSANGVSSIIEAMKIAS 142
gi 751837238  109 LEhrdaekRFVNARRLLYILQGTFAE-------------------TTSPEHQLHWIIDNAKLVRSADGLSRIVDAIKISS 169
gi 568452416   99 LEhkdteiRFTNARRLFYVLQGSFAE-------------------TGSPEDQLHWIFENAKTVRDADGVSCIVEAIRIAT 159
gi 685944514   87 INadklseRLRASRKLLYLFQGTFSE-------------------ARNSRHQLECIIDNVHLIRLCGGLQSVTQALQAAV 147
gi 588261343   87 INgdklseRLKASRKLLYVMQGSFIE-------------------SKSTKHHLDCIIENVKLVRECGGLNKIASALRAAI 147
gi 634349834  299 LAspdpdaRFTVARHLLYIAQGTFES-------------------STSPDHHLELIQANCALLRNAKALDAIWDAVKKTG 359
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74594254   283 EKS-----------RVSApsesnaas--------------------esanpmllAAADR---EANLVLTAFYLMVETARM 328
gi 552936482  162 RAH-----------DHYSrpdfi---------------------------sdrqAYIDDintEIGFCLTLLYMLVEVHRG 203
gi 353236098  156 VKH-----------DQLAtiadadlar------------------inaaphmrqSWIDEvqaEIAMCLNMLYPIIEVFRS 206
gi 169860557  168 RKH-----------DLLSnlsdqdaah------------------fhisvqdktDLLEEvltEISVYLGMLYHLIEVFKG 218
gi 170087030  143 HKH-----------DLLYnlsdqdaah------------------fhisaqekaDFIEEvltEISVYLGMLYHLIEVFKG 193
gi 751837238  170 SKHdvlsnisesdtRHLGisqa-----------------------------ekqDFIEEvntELSMYYAILYFMVEVMKG 220
gi 568452416  160 RKH-----------DFLCglsdqdamr------------------fnisqadksDLLEEiltELSVYYGALYHLIEVFKG 210
gi 685944514  148 SFHavvhsey--------------------------------------ahlaepDFVEQlniELGGYMEMLYYMVQILRD 189
gi 588261343  148 SFHsivhtdy--------------------------------------ahlaepDFIEQvnvELGSYMEMLYYMVQILRH 189
gi 634349834  360 ERW-----------ERVShlpntnpgsndpsssagagesqplnivefeeaqhrqEQLDEinsELALLLAVLYFMMEVHRG 428
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74594254   329 qetrdpkHTPLRDAITALEPDLMVFLIEIIARLRWDD--ASNIPLTRIILLFWKCILLFFGGSDMLKQAKETLEPafDCg 406
gi 552936482  204 -------DDSFGSELVELDPPMSVFLFEIIASLREKEknAKGYPVKKLLLLSWKVVLVSLGGSNDIQKLKDVVRLinGLa 276
gi 353236098  207 -------DDEFAEELMGMEPPLPIYFLSLLSTLGNRS--AKSYPAKKLLLITWKVLLACLGGMNEQARAKAVARElaGLp 277
gi 169860557  219 -------HEDFADELMSLDPPLPVYLFNLVAGLRDKS--AKGYPIKKLLLVLWKTLLACWGGMKDHERVKKIARElaGL- 288
gi 170087030  194 hd-------dFADELMSLDPPLPVYLFNVVAGLREKT--AKGYPIKKLLLVLWKTLLTCWGGIREYERAKRLTREl---s 261
gi 751837238  221 -------DEDFGDELMSLDPPLPIYLFSLVASLKEKS--LRGYPVKKLLLVLWKSLLTCLGGIRELTRVKQLGRElaGLi 291
gi 568452416  211 -------HEDFAEELMSLDPPLPIYLFSIISNLRDKS--AKGYPIKKLLLLTWKTLLACWGGIRDYARVKKLSRElaGLp 281
gi 685944514  190 -------DNSFAEDLMHLDPSLPTYLFSLLSGLRDKT--AKGYPVKKLLLLLWKTLLVVLGGWKDIDRIKELSYDlfscs 260
gi 588261343  190 -------DSTFADELMNLEPSLPTYLFTLLSGLRDKT--AKGYPVKKLLLLLWKTLLVVFGGWEDIDCLKDISYElfkcn 260
gi 634349834  429 -------DDDWAEELMQLDPPAPIYLFNLVAGLRERN--AKGYPVKKLLLLLWKSILACIGGQSDIPRVRALVRSiegle 499
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74594254   407 KNDPtrrt--------------------------------pflTASPLDYHNFRQEITSKYPAY----NPPPPVIPLEL 449
gi 552936482  277 PIHNkef----------------------------------liKTTPIDYHTFQNEVTQKYPTYvpppcpvipmppitt 321
gi 353236098  278 PLTEasl----------------------------------mlKATPVDLQTFREETFVKYPTF----SPPPiteaakv 318
gi 169860557  289 --PNsegp--------------------------------dkiKSTPLDIEQFRQETAVKYptftppphpppslaeapi 333
gi 170087030  262 GLPVgesg--------------------------------driKSTPIDIETFRHETFVKYPTFtaaqQPPPQVaeapi 308
gi 751837238  292 EMVQdq-----------------------------------tiKSTPVDFYTFRQESAVKYPTF----VPRPPGSDKEL 331
gi 568452416  282 PVTDpns----------------------------------klKTSAIDIEQYHCETSVKYPTF----TPPACPPhnla 322
gi 685944514  261 LATKddn---------------------------------tivKSNPVDLQQFFTQTSLKYPTY----KPNAQPLPLng 302
gi 588261343  261 LAVKddn---------------------------------tilKSNPLDLQQFYSQTSLKYPTY----RPKQQSLPLng 302
gi 634349834  500 PNPSrprtpapqtrpfppssssstcdvpssptdsviadvkphtKVAPTDFVAFNSEITSKYPSY----IPPPLPIKLpi 574
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