1J57


Conserved Protein Domain Family
NuiA

?
pfam07924: NuiA 
Click on image for an interactive view with Cn3D
Nuclease A inhibitor-like protein
This family consists of protein sequences that are similar to the nuclease A inhibitor expressed by bacteria of the genus Anabaena ((NuiA). This sequence is organized to form an alpha-beta-alpha sandwich fold, which is similar to the PR-1-like fold. NuiA interacts with nuclease A by means of residues located at one end of the molecule, including residues making up the loop between helices III and IV and the loop between strands C and D. The mechanism of inhibition of nuclease A by NuiA is as yet incompletely understood.
Statistics
?
PSSM-Id: 311741
View PSSM: pfam07924
Aligned: 29 rows
Threshold Bit Score: 116.96
Threshold Setting Gi: 504944592
Created: 25-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1J57_A         14 SEILEQLKQASDGL-LFMSESEYPFEVFLWEGSAP-PVTHEIVLQQT------GHGQDAPFKVVDIDSFFSRATTP-QDW 84
gi 159894523   24 ETSVEKITAAANGL-LMMSETDAPFTPFAWDAAT--PFSPEALAN------------GQPIQTISLEQFLGNATTV-QEW 87
gi 504964830    3 QSITEELANLTQDL-LWMSEADYPWEVVSYDCSN---VTPENLLEQS------NLPSDTLIKTVTIERFFAPALRE-QSW 71
gi 504971080    4 AAIIDLLKQVTTDL-LWSSESDYPFEIVTWDRGVA--MTPTALFSKL------ANP-DAAIETISLTDLFAPVLTV-ENW 72
gi 504964488    6 TPLTEQLAELTNRL-FWLSESEFPFQVIIWDTD---RVTIEQLLKLT------YHPPNTPVQTLTIHEFFAPALEGlGSF 75
gi 373894392   10 ENTQTKLENAADGL-LMMSESDYPFDYFTTTDEV---VDDNLILKLA------GKPAGTLVEKTTLDYLLRNMTNP-AS- 77
gi 752565197   45 lRIYRDLNTLTEGL-LYPSESDYALNLIRLPLNAI-P-TNERLADLL------GL-GNKTVTSEQLDRFIRRRFTD-FAG 113
gi 504944592    6 ANLLAQLEELTPGIcLYYSDSDYTFKPIIWEVDTKgELTIENLLREVtppfdeYRPGGKIIKSANLDNYLQMIYQEaRKY 85
gi 1108646262 170 DPALATLRDMTTGL-VYMSEGDAPLEPVSFAAPAG-SLTDATLAQLA------GLPADTKVEKQELTYFLRNHTAD-NGV 240
gi 501191540    4 EELLASLAEAAQGL-LFPSESDHELRPFRSRGD---ASSPAALLAAE------GLGAATPVEVTTAGDFFAPVIDV-PGD 72
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
1J57_A         85 YEDEENAVVAKFQKLLEVIKSNL--KNPQV------------YRLGE-VELDVYVIGETPAGNLAGISTKVVET 143
gi 159894523   88 HGEAEKATVSQFQQLVEVLKAEL--TDIQV------------YRVGE-INIDAYIVGKDSAGNLVGLKTQLVET 146
gi 504964830   72 HNEEERATRNRFQQLFNFLNEQL--NDLIV------------YRFGE-VEIDVYVLGTVEDKT-VGLKTTLVET 129
gi 504971080   73 YEDAELAQVKRFTDLLHAIESNL--ADVKV------------FRVGE-VEIAIYIVGKTPDGEPIGLKTHAVET 131
gi 504964488   76 SYLLDQALIGRYRILYNYLTYYL--DNIKV------------YRVGT-HPIYIYIMGITRDENLAGIATQIIET 134
gi 373894392   78 -GSVSPEIATRFSQLSTALKQEL--SEPEV------------YRVGD-RQIDVFILGKTNEGVIAGMRTKLIET 135
gi 752565197  114 IDPETRTTYRRFRELGAYFNRTFgaTNCHA------------YRIDT-IQVKVLFLGFKPGCGYIGIQTVAIET 174
gi 504944592   86 DPDIAVEIAQIYQTVIKLLQSSL--TFLEVaeirelndpnstFRI---------IFGSTKSGEWIGIAPQLeae 148
gi 1108646262 241 LGNPELA--NRFKALQMYLKQEL--SGTQV------------YRLGTgPQVPVLVLGEAEGGKLQGFKTVLTET 298
gi 501191540   73 AGDAALAEAGRYRRLVDLLERHL--TDVRV------------YRVGR-VAIDVYVVGRHPSGAWLGLVTKVVET 131
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap