Conserved Protein Domain Family
Vps54

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pfam07928: Vps54 
Vps54-like protein
This family contains various proteins that are homologs of the yeast Vps54 protein, such as the rat homolog, the human homolog, and the mouse homolog. In yeast, Vps54 associates with Vps52 and Vps53 proteins to form a trimolecular complex that is involved in protein transport between Golgi, endosomal, and vacuolar compartments. All Vps54 homologs contain a coiled coil region (not found in the region featured in this family) and multiple dileucine motifs.
Statistics
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PSSM-Id: 336868
View PSSM: pfam07928
Aligned: 117 rows
Threshold Bit Score: 79.483
Threshold Setting Gi: 915015117
Created: 25-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74857755   750 EPFKVVNTSLMLLKFINDYLCCCEKLP-TIIIDSLPKIIEILNTFNSMTHQLVLMAGARQ-TMKLKT--ITSKHLGYASQ 825
gi 124453716 2109 SKYKVTQAFLFFLQAISQYLHLFESYS-VINYEQTQKLVELIKCYNSLATQYILGAGAVH-FGKIST--ITAKNLAISSI 2184
gi 121979694  773 QTYKLTSAFLQILKMIYEYLHLIDYFK-SMRETSSKKLIELLKFYNSYANELLIGGGAFQ--LGVQ---VSAVNLALSSV 846
gi 122123833  828 dgRVVSVSLQILLEMLHDYDGYLGRFP-FLAFDIMGKVYDLLRLYNSQCAALLLGAMAVE-TGTLES--ITVPHMAVASQ 903
gi 569405381  549 vpcKVVKSVLTLIECCFEYLQCSHKLN-VVTEDISSKVVEIMHLFNHKTCDLILNATAMH-TVGLTS--ITAKHLALAQQ 624
gi 294945031  138 gSFLVVPAGLGILELIAVYLDVARALP-QLATDAAVRLTSMLRLANGQIEKLLLEGQAVS-SGSRKT--VTATNLALTYQ 213
gi 118359846  816 KKYMFSEGFLVFLKQVQKYIGIMAESKiQYSKEYFIRFISLLRQYNTFSREFIVLAKGKNpQFPQMNgkVTVKNLATSSL 895
gi 449704240  573 ETYFMTNTMSILLPTLERYREIIIKFP-LLGECALSSAKDMLILYNNSMRRLILGKELIQ-KGVVQR--IGATMFTTTHQ 648
gi 915015117 1422 EEFAVAPSVLVTLALMQEYLSLALWLP-SLQSAAFTSLGDLLLRFVRVSVQLTVGGGAVQ-RQQLQR--ITAGVLGRVAR 1497
gi 298712046  808 ASFKAVGSALLVAEMSANFLQFADHFP-TIGTDILTRLGELLRVFNSRATQLVLGAGAIHsTAKLKS--ISAKHLALCSQ 884
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74857755   826 SLSFQIKLIPYIKVIVSRS------LTVKQLSLLNG-LDKLLQDFVSHRQEIFNKFVVIIKER 881
gi 124453716 2185 CLRLFLYLLDPLSNKLFKVinqqqqTEFTNLQQIQNdFATIKVDYENHNAEVMAKLTTIVQDR 2247
gi 121979694  847 CLQFALKIFPQMTERIIGLy----kEDRDLAENIEDqFSRLSDEYNNHNINIQKTISDILikl 905
gi 122123833  904 NLALLYDGIPLMQRRWERVv-----DGDNLPSSISEdLERVRQGCQMCRLELLGKIAALVKEK 961
gi 569405381  625 SLFIVMCLLSGMEQWFSKSi-----PANRVASLIDQ-MQKCRQNVEAHMHKIDEKLISIMQGl 681
gi 294945031  214 TIDMLSSVLPLIANTLESIagk-leSGPGIRIVLEDlLYRLKAEMSEHKGNLTRKLGDILVER 275
gi 118359846  896 NLTFLIKIFDKIKERLVQN------TDVSKEIIDAE-FQKIKIDIQNHISEIFGTIPNIIKDm 951
gi 449704240  649 TLLLLSLITPYLHHYLS----------PNVIISGRI-LDGIEDLMKAQCTDIRNALTIIVRNR 700
gi 915015117 1498 SFDCLLLLLQRLIDSLSQQq-----RLQQQQQQGQQqQQHQEQQQQQQEQQQHRRLNTIeeew 1555
gi 298712046  885 SLGLVRSLIPFLKAALSDEdc---rRSTTSCWRRSG-RRGARLDYRDHRDKILTKFVSMIEEL 943
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