1QHX


Conserved Protein Domain Family
CPT

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pfam07931: CPT 
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Chloramphenicol phosphotransferase-like protein
The members of this family are all similar to chloramphenicol 3-O phosphotransferase (CPT) expressed by Streptomyces venezuelae. Chloramphenicol (Cm) is a metabolite produced by this bacterium that can inhibit ribosomal peptidyl transferase activity and therefore protein production. By transferring a phosphate group to the C-3 hydroxyl group of Cm, CPT inactivates this potentially lethal metabolite.
Statistics
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PSSM-Id: 311747
View PSSM: pfam07931
Aligned: 7 rows
Threshold Bit Score: 219.984
Threshold Setting Gi: 81721447
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QHX_A         3 TRMIILNGGSSAGKSGIVRCLQSVLPEPWLAFGVDSLIEa-MPLKMQS---------------AEGGIefdad------- 59
gi 81721447   24 GMVILLNGTSSSGKTSMARALLDILDGTWFHMPVDAFHA--MRCKRDI---------------SDEEL------------ 74
gi 81634388    8 GRIVILNGAPRSGKSSIAEAIQETFDGPWMNLGVDAYMEr-VMPRRCL---------------PGIGLrpgge------- 64
gi 81721391    2 ADVIVLNGGSSSGKSGIVRCLQAVLPDPWLALGTDTLVDa-MPASMQA---------------SDAGIefapd------- 58
gi 81779313   59 ARIVLLNGVGSAGKSSIARALQTITAAPFLHVQMDSFLEm-LPDALQD---------------HADGFsyetvrqdgkpa 122
gi 81399036    2 ANIIFLHGTSSSGKSTLSQVIQKQSETPFWHFASDQFVEagMLPKRVN---------------DGGDFdw---------- 56
gi 614094731  23 GKLILLNGGSSAGKTSLALAFQDLAAECWMHIGIDLFWFa-LPPEQLDlarvrpeyytwdsavEADGLewft-------- 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QHX_A        60 ggvsiGPEFRALEGAWAEGVVAMARAGARIIIDd----VFLGGAA-AQERWrSFVGDLDVLWVGVRCDGA-VAEGRETAR 133
gi 81721447   75 -----QPEIDRTAKGFHRAVAGMAAGGNNLVVD-----YPLSRRWrLLDLL-DLLVPEDTVLVGVRCPLP-ELERRESER 142
gi 81634388   65 -lpeiEALVPLFYAALYESVAAHSRLGLNVVADvghhdAYGEPRHiLPDCArRLL-GLPVLFVGVRCPVEtIMERRNRGQ 142
gi 81721391   59 gevivGPEFRTLEAAWIEGVAAMARAGARVIVDe----VFLGGAD-SQQRWqKALRDLRVLWVGVRCDGA-VAAGREIAR 132
gi 81779313  123 vviraGPVGERTLRGMRHAIAAMAGQGNDLIVDd----VLCNGE--LSDCV-DLLSAFDFHLVGVMAPLE-VLEAREARR 194
gi 81399036   57 -----sKNRPLFFDAFHGCIKAVADAGNNIILDh----IIESKEW--FHYLqELLSNHDVFFVGIHCPIE-VLREREINR 124
gi 614094731  94 --vhpGPILDLAMHSRYRAIRAYLDNGMNVIADd----VIWTREW-LVDAL-RVFEGCRVWMVGVHVSDE-EGARRELER 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
1QHX_A       134 GD-----RVAG-------------MAAKQAYVVHEGVEYDVEVDTTHKESIECAWAIAAHVV 177
gi 81721447  143 GD-----RQPG-------------LAAMQYGAVHSHELHDLDIDSSLHTPAECALRIRDFLP 186
gi 81634388  143 PG-----REGGyltgseaepvprqVLAWQRE-VHRPGIYDLAVDTSMMTPDECAALIRKRLE 198
gi 81721391  133 GD-----RVIG-------------MAASQADVVHRGVVYDLEVDTTHAESMECARAIATHVR 176
gi 81779313  195 AD-----RLPG-------------LARWQYERVHAGISYDLEVDTSQSTPLECARRIQQRFQ 238
gi 81399036  125 GDgsignRYLG-------------ESEYHLKHVHTYSAYDYEIDTSSQPTEHSAEMVLSAWE 173
gi 614094731 165 GD-----RHPG-------------WNRGSARAAHADAEYDFELDTTATPVHELARELHESYQ 208
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