4EJY,3I0W


Conserved Protein Domain Family
OGG_N

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pfam07934: OGG_N 
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8-oxoguanine DNA glycosylase, N-terminal domain
The presence of 8-oxoguanine residues in DNA can give rise to G-C to T-A transversion mutations. This enzyme is found in archaeal, bacterial and eukaryotic species, and is specifically responsible for the process which leads to the removal of 8-oxoguanine residues. It has DNA glycosylase activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18). The region featured in this family is the N-terminal domain, which is organized into a single copy of a TBP-like fold. The domain contributes residues to the 8-oxoguanine binding pocket.
Statistics
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PSSM-Id: 336872
View PSSM: pfam07934
Aligned: 61 rows
Threshold Bit Score: 67.2968
Threshold Setting Gi: 81580521
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4EJY_A        26 VIVRGIAD--FNLKETF--ESGQCFR--WN--EEed--gsYTGVAYD-----RVVNVKl-EG--DTLIIDNTNL--T--- 82
gi 123583035   5 FIEHSEA---VDINHCL--FSGQSFS--WQ--KHgndgryVSAIING-----SAVVIEn-TN--DGGVVLHTDgnti--- 64
gi 123579872   6 LITHNKE---LEIEKSL--FSGQSFL--WK--KHqsnldsFVTVMDK-----RLVIISq-LS--PYTIRVHCDsevl--- 65
gi 81791361   14 SLLNTKSR--LNFKDTV--QSGQSFR--WN--LNetlksyYSSVIYN-----SIIFICe-IN--SEMIEVLCTdqel--- 74
gi 121725524  11 IVDFNEYVgdFDLILTM--NSGQTSQppWK--MDdn---nYYEII-LidnidVLVKISq-EKlnDPLIVKYFSkeef--- 78
gi 81580521   10 SIAVPKE---FCFQENLryLSRSNNEcmFH--IEdn---kIYKVI-PvqdvnPLVEISvnTD--GNIQIRCLEEpyTsek 78
gi 81600734   11 IIALPEE---FDMNANLgyLKREKNEcmYE--TEnd---hITRMI-AigeirSLIQISviDN--KQMVVQFLNDsrPsee 79
gi 754081420   9 fIRISGVH--IDFDATF--FSGQCFR--WK--KMdd---fYIGVVDE-----KIIFIKpqDE--DTFDIYNCSPd----- 65
gi 501155434   1 MYQITVEN--FDIRKIC--YSGQCFR--MK--EIse--tsYEVVAYG-----HYLRISq-QD--NELTFSCTe------- 55
gi 501499830   5 tIIKTRAP--FDIRQTL--FSGQSFL--WNinKDep--dfYAAIIKS-----KPLIIKq-IA--DNELE--VYA--Edkv 64
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
4EJY_A        83 ----DFYDIWFDYFDLGRDYGQIK-ESLSK-DPVLKEAIKfgQGIRI-LRQDTWETL 132
gi 123583035  65 -gveSPQVWFRRYFSLDVDTETLFsEPFRNaHPELALQLEryRGLRV-LRQDPYETM 119
gi 123579872  66 -ygqKISAFISHYFTLDVPFQKIFsSSFKSnYSEVWRLLDgyKSIAL-LRQHPFETL 120
gi 81791361   75 -sgkPINEFLKHLFSLDFQEETVFsSRFQQeFPEVWNLVQsyRSVRV-MRQDPFEIM 129
gi 121725524  79 -nveKLRTKLFYIFDLDYNINEVY--DFLEeNSQLSDVYEfnRGLRLfKSQFPFECI 132
gi 81580521   79 sireAVVNYVKEWFDLTTDLAPFY--TLAKhDLLLQGPIEqyYGLRTlGIPDLFEAL 133
gi 81600734   80 wqreKIVKYIHEWFDLNTDLTPFY--EMAKaDPLLKKTVEtfYGLRVvGIPDLFEAL 134
gi 754081420  66 ----EFKKSFYWYFDLDKDYDEIL-EKLSGhDSILKEAVEkyRGMRL-LNQEPFECM 116
gi 501155434  56 ---gEFHSIWNEYLGLNVDYDTIT-GLVNEdDRYMKSAMSfgWGIRI-LKQELWETI 107
gi 501499830  65 ingvPLVDFISHYFTFDIDTEQIFpDNFSHlYPTLWQLLTdyFPVRI-MRQDPFETM 120
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