4FNV


Conserved Protein Domain Family
Hepar_II_III

?
pfam07940: Hepar_II_III 
Click on image for an interactive view with Cn3D
Heparinase II/III-like protein
This family features sequences that are similar to a region of the Flavobacterium heparinum proteins heparinase II and heparinase III. The former is known to degrade heparin and heparin sulphate, whereas the latter predominantly degrades heparin sulphate. Both are secreted into the periplasmic space upon induction with heparin.
Statistics
?
PSSM-Id: 336874
View PSSM: pfam07940
Aligned: 76 rows
Threshold Bit Score: 80.1411
Threshold Setting Gi: 123319323
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FNV_A       418 TPNNDMKLFDQAGYYVLRN----GwtpaS-TVMILSNNKSNdasnslsayshnQPDNGTFELYHNGRNFFPDSG---VCT 489
gi 123517431 435 TGTRKDFAAPDGGYYVLRA----D----T-GFAFTRCATFRdr--------pgQADILHCDLWWQGQNIALDAG---TYS 494
gi 81758538  380 LNKPSSFHFAQGGYAGLRS----Q----TgAFVLFNYPIFRfr--------paQNDALHVDFWLDGVNLLRDGG---TFS 440
gi 81500915  388 VPPARSTHMEAGGYGLLRY----G----R-AFALFNLPHHRhr--------psQADALHVDFWLGGKNLLRDAG---SFS 447
gi 81442624  418 TPNNDMKLFDQAGYYVLRNgwtpA----S-TVMILSNNKSNdasnslsayshnQPDNGTFELYHNGRNFFPDSGvctYYT 492
gi 75430706  386 APNFLSKALSNAGFYTFRSgwdkN----A-TVMVLKASPPGef--------haQPDNGTFELFIKGRNFTPDAG---VFV 449
gi 81442627  393 LPDYMSKGFLKSGFFVFRNswgmD----A-TQMVVKAGPKGfw--------hcQPDNGTFEMWFNGKNLFPDSG---SYV 456
gi 123647221 290 gynfknqnnELGGYVVLNN----K----K-NSLIMDIGSSPnkkl----ssdyQAGALSFEIISNNKKLISNCG---YFQ 353
gi 81436605  334 MKPKELFRGESSGLMAYKA----E----D-IYFTLFNGLHGsa--------hgHASTGGFTLQLQGDDLFSDSG---RYS 393
gi 123463281 136 GRGTCPVFLAKTNWTK-------G----NgFYLAMKGGSSNls--------hsHQDAGSFIFEANGVRWASDLGiqdYDQ 196
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FNV_A       490 YytsgGD-----------ND-LRYWFRGIDKHNTLSIGKQ--Ni----kKAAGK---------LLK----SE--EGaTEL 536
gi 123517431 495 Y----NAp----------EP-WNNPLAHTAYHNTVTVDDR--Dq----mDRAGKflwfpwlkgKVRcmkrSE--TGhLAY 551
gi 81758538  441 Y----NAg----------QA-YIDYYGGTQSHNTVQFDEH--Eq----mPRLSRfllgawlkaENV----HW--DEaRQY 493
gi 81500915  448 Y----AS-----------AE-SAGYFSGTASHNTVQFDQR--Dq----mPRLSRflfgawlkaRDVepvkQT--ADgVTC 503
gi 81442624  493 S----GGd----------ND-LRYWFRGIDKHNTLSIGKQ-------------NikkaagkllKSE--------EGaTEL 536
gi 75430706  450 Y----SGde-------aiMK-LRNWYRQTRIHSTLTLDNQ--N------MVITKarqn----kweT--------GNnLDV 497
gi 81442627  457 Y----AGeg-------evME-QRNWHRQTSVHNTVTLDNKnlEt----tESVTk--------lWQP--------EGnIQT 504
gi 123647221 354 K----ID-----------HQ-LNEISKSSAVHSTLILDDK--SscnfnkVRGKKskinqelriLKK----KVvfEKnYWK 411
gi 81436605  394 Y----VN-----------KS-ERLQLKECASHNTMFIAEN--Ph----tLVSDTwgyd-klptPLF--------QQiKEL 442
gi 123463281 197 L----NRdgvkisnfgqqSErWTVFRFMSIGHNTLTVDND-------------LhnvagyvgfTQT--------FEdDNK 251
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FNV_A       537 VVF---ENQGYd-----NLKHRRAVF-YVNK--KFFVLVDEGIGNAEGT---INLSFNLc--EgtASEVVMDtDKNGV-- 598
gi 123517431 552 WEG---THDGYlrl-psPVEHRRGIL-QLGP--ESWLVIDRLSGSKAHR---YRLRWLL---P--DFNHVWD-ESIGL-- 613
gi 81758538  494 CSA---SYRDYf-----GCGHKRYVS--LSN--STLRVVDDIHGVQKK----AILRWRLn--P--GKWIIEG---NRV-- 548
gi 81500915  504 AAG----YRDWq-----GASHHRALT--LGR--KSLRVVDRVGGFRRS----AVLRWRLc--P--GAQLSGN-------- 554
gi 81442624  537 VVF---ENQGYd-----NLKHRRAVF-YVNK--KFFVLVDEGIGNAEGT---INLSFNLcegT--ASEVVMDtDKNGV-- 598
gi 75430706  498 LTY---TNPSYp-----NLDHQRSVL-FINK--KYFLVIDRAIGEATGN---LGVHWQLk--E--DSNPVFDkTKNRV-- 557
gi 81442627  505 LVT---ENPSYk-----NFKHRRSVF-FVDN--TYFVIVDEVSGSAKGS---VNLHYQM---P--KGEIANSrEDMTF-- 563
gi 123647221 412 INA---SHDGYsk--plGIVHDREIEfYPEQ--LKFIGHDKIISNKGIKnlkFDIRFHLe--P--NIRLMKTqDEKSI-- 478
gi 81436605  443 SVGffaECGWLdkadqnPMIFERSFI--YLKsiNSVVIIDSFAGQKETE---ITSTYNLa--P--SINCQKEaHRFALtt 513
gi 123463281 252 LGGqmnMVDLFfg--klSKSLRTVLL--LNN--EYLEVTDDIVCGDTA----VLVTWTMi-tP--TSDATVIsTNQ---- 314
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FNV_A       599 ------------HTAFSNN---NNIIVRTFAN----------KAVTcspftgriayLVDGAY--NTRqsYT---IDMNKS 648
gi 123517431 614 ------------LTLRTEA---GDYHLQAGAEprngsytlvcADED----------SPRGWR--APY--YN---YREPAL 661
gi 81758538  549 -------------TNHTHS-----ITISSNTDi---------KRLE----------LVEGKE--SRY--YYq--ETSIPV 585
gi 81500915  555 -------------VVQSEAgnlTV-TADVPIR-----------RIE----------LTSGRE--SRY--YLq--TEPIPV 593
gi 81442624  599 ------------HTAFSNN---NNIIVRTFANkavtcspftgRIAY----------LVDGAYntRQS--YT---IDMNKS 648
gi 75430706  558 ------------YTTYRDGnnlMIQSLNADRT-----------SLN----------EEEGKV--SYV--YNkelKRPAFV 600
gi 81442627  564 ------------LTQFEDGsnmKLQCFGPEGM-----------SMK----------KEPGWC--STA--YRkryKRMNVS 606
gi 123647221 479 -------------LIDLDG---EGWKFSSENS-----------KIN----------IEEGLY--FGE--KN----SFTNN 513
gi 81436605  514 nkhkytllfaggQTQQSVAkgsEI-YNQLNEHprlsnkfcykTGKE----------IQATVIspLED--IQ---ITPIKV 577
gi 123463281 315 -------------VRIGNGqksLLLTVESPSD----------ATLS----------VTNNDP--IHD--YD---AENPNT 354
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
4FNV_A       649 Adeta------ryitVILPVNGS------------------------TDTS 669
gi 123517431 662 S--------------LDLTVHGSqtffwtlfspesicveksedhvilRSPT 698
gi 81758538  586 Le-------------IEVTSDG-------------------------QITT 598
gi 81500915  594 Le-------------VELDRPG-------------------------TLTT 606
gi 81442624  649 Adeta------ryitVILPVNGs------------------------TDTS 669
gi 75430706  601 FekpkknagtqnfvsIVYPYDG-------------------------QKAP 626
gi 81442627  607 FnvkkdnenavryitVIYPVKKs------------------------ADAP 633
gi 123647221 514 Qn-------------IFISGMTn------------------------EENQ 527
gi 81436605  578 SqtgeneqfcqakgfRIIAGSEKfdlfvm-------------redivKGNK 615
gi 123463281 355 Kr-------------ILIKVNYa-----------------------aNEEK 369
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap