Conserved Protein Domain Family
DUF1682

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pfam07946: DUF1682 
Protein of unknown function (DUF1682)
The members of this family are all hypothetical eukaryotic proteins of unknown function. One member is described as being an adipocyte-specific protein, but no evidence of this was found.
Statistics
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PSSM-Id: 336876
View PSSM: pfam07946
Aligned: 168 rows
Threshold Bit Score: 149.223
Threshold Setting Gi: 156088967
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74632713    81 DWSKEAFIVAFIVFYVGLFYLGSSLNKKKINGWVDANKAVLASQFYQvganpVGV-------------------KD---R 138
gi 675860370  118 SFYMEILMLAGLGAYLLNYLAGKTKNQKLAQAWLKSHKQLLEENFSV-----IGD-------------------DGttmE 173
gi 156391215   63 gFYVEILTLAGLAAYALNFFAGRTKNSKLATAWLKSHKELLESNFHI-----VGD-------------------DG---Q 115
gi 115871278  139 SYYLELLMLAGVAAYLLNYMNGKSKNQRLATAWLNCHKELLEANFAL-----VGD-------------------DG---S 191
gi 358339929  187 SYYLEMLFVSMLVIYFSNFLVGRSKNTQLATAWFAAHKPILETQFAM-----VGD-------------------DGq-aE 241
gi 576694947  125 HYVFEMFFLAFIFLYLVNYMHGRATNSRLAAAWFAAHENLLSTNFSM-----VGD-------------------DT---S 177
gi 1084301063 161 NFRLEILFVLALMIYTLNFLIGRSKNTQLANTWFSAHQPLLETNFAV-----VGD-------------------DGl-aE 215
gi 198415840  128 kYYVEILMALGIFVYLINFFIGKAKNNTLASSWLSHHLDFLHKSFAL-----VGD-------------------DP---Q 180
gi 674590128  122 kYTIEMILLAVILIYLVNYLHGRSVNSRIANLWYETHRDILTANFAL-----VGDnpnvvsvvednqesdsmneSK---S 193
gi 1133460060  99 aYLVEICICLGIALYISNYLLGRTKNTNIAEGWMVHNLPILHSQFVL-----VGD-------------------DG---E 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74632713   139 -------K---I------------------LVADTPSNFTTYATGRINIDSLTAKAKLKTRQNLLTLMFEYV---FSFFM 187
gi 675860370  174 at----nT---G------------------LMKEAENIYSLWCSGRTCCEGMLVTIKMLKRQDLLSTISRMF---R---- 221
gi 156391215  116 ae----ePqqgI------------------MVKESESLYSLWCTGRTGCNGMLVELKLQKRHDLVNVMSYLV-------- 165
gi 115871278  192 ke----mP---Tsv---------------nLLKQSENRYCLWCSGRVFCEGMLVELKFLKRQDLLSVISRTM---H---- 242
gi 358339929  242 pg----sG---T------------------LLKESEHLYSLWCSGRAYCDAMLVELRLLKRQCLVFTLANW--------- 287
gi 576694947  178 at----pE---GnqeretsrggeksssnrrLIRESDSLYTLWCSGRVACTGMMVELRLMKRQDLPSLFLHWLhrpKSGVN 250
gi 1084301063 216 pg----tG---T------------------LMKESEHLYSLWCTGSVHCDAMLIELRLVKRQCLFFAIANWI---R---- 263
gi 198415840  181 nkkiestN---E------------------LQKESEHVYTLWCSGRQCCEGMLVELKLLKRQDLISVIAH---------- 229
gi 674590128  194 ds----sL---G------------------LLRDSDSQYTLWCSGRVACQGMLIQIRLAPRQDLCLGLMHYL---ARPKT 245
gi 1133460060 152 ge----ePtqnH------------------VVRRSENSFTVWASGRINCDGLLVHLELMKRHDLIHVILGLF---R---- 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74632713   188 DAVPVPTDEVTITLKInkNASVPDGIWAIVHKDAMRKAREDQYFL-S-L-----T---KTS---D---S-----DK---L 243
gi 675860370  222 ----PATDQIFVKVIMd-DSDMDNFVFCLSHKRSITKLQKDHADL-SnF-----C---PEKkscE---K-----FL---I 276
gi 156391215  166 ---KPVKDSITVTVHMt-DEEMDNFVFAIVPKKTVSKMQKELQDL-S-Ff----C---PDK---K---Sga--kYD---L 221
gi 115871278  243 ----PAGDEIKVTVTLd-ADSMDSFVLFFGAKKITNRMLKDMQDL-SqY-----C---GDKrggD---K-----FG---L 297
gi 358339929  288 --FQPAYDTIVAKVIMe-DSEMDGWVMAVGRKRRLQVLMKDHQDLaF-F-----C---PDK---RgqrH-----PG---L 344
gi 576694947  251 AATIASDDRVVVKVVLe-DGEMDTWVMAVGVKKSITMLAKDHFDL-A-------T---YPV---D---RrgqrfNG---V 309
gi 1084301063 264 ----PVHDSIVVKVIMd-DSEMDGWVLAVGRKRRLQALAKDHQDLaV-Y-----C---PDK---RgqrH-----SY---L 318
gi 198415840  230 -QMKPINDQVTISVKMt---TLPSLVFCVGIKKSITNLHKTMQDL-C-LycadkA---KMG---E---K-----YN---L 286
gi 674590128  246 GPLSVSSDRLMIKVVLd-DGELDSWVFTVGVKKSLSVMVKDHFDLaT-Y-----P---QDR---K---G-----FKyagL 304
gi 1133460060 203 ----PVPDTISFIFQCa-DGDMDSVITAICPRKTATKMSKEYEDL-SkY-----CsgiRSG---E---K-----HN---L 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74632713   244 PVSCVFMSEN-SELTEKLYNPALKELLTETAPYFRYLAITDLP--S--E-RPN---KA----Seye----ksL------- 299
gi 675860370  277 PSHFQMLSEC-SEVTAFILDSKVTAVLKKYEGAVEYLHFSDQYagV--K-QPEdstTT----Kvp------eT------- 335
gi 156391215  222 PASLVILSES-NEVANTLLTQQVTKAISNHEDMFESLLFSDQY--V--G-PKQ---ED----EdqaaakplkP------- 281
gi 115871278  298 PASTVVLAEL-GEVVNGVLDTKVLNCLNSHPEMFDYMHISDQF--S--GpKPA---AE----Deqpt-tmppT------- 357
gi 358339929  345 PESLTVLSEL-SEATTSMLNAPICKFLTDNEECVDYLFFSDQY--TgpK-PPP---DEtpsaKlp------vT------- 404
gi 576694947  310 PEGMIVLSEI-AEATATILNPTVLKVINDHQSAIEYIYISDQY--S--G-PKA---SM----Eel------kPpkp-eei 369
gi 1084301063 319 PESFMLLCEI-PEVVPAIFNPLVCKFLNDFEESIEYLFFSDQY--S--G-PKP---PQ----Edt------tTptkppvt 379
gi 198415840  287 PLSMLMLSELyGDVPAFILDSTVVRVLKDHQNLFDSLHISDQY--Sg-A-KPL---DQ----Ndd------aPaip--et 347
gi 674590128  305 PEGMIVLSEI-PEVTSAILNPTVLKIFNDHPNIIEYIYISDQY--Cg-A-KPS---AE----Elk------pP------- 359
gi 1133460060 258 PSSLSVISET-FDSAISVLSGGVAKFLSNHADMLLSLHVTDQY--T--G-LKE---EG----EesetvtikkG------- 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74632713   300 Vga--tKTVVLKLN-IP----S--GATd-------------------------LAKTAQLLETAINLVDTAtKLNLRPEV 345
gi 675860370  336 Q-----KVLIFCFN-VTdsgfT--SPKd-------------------------MDHMKPLLQMVFYCMDKIkRFRLSKEA 382
gi 156391215  282 K-----KVLIFNFT-VA----S--KGNtkv---------------------qdMARLESMMKLVLHCIDRVrKFRLGKEA 328
gi 115871278  358 E-----KVLICNFK-VP----GngSKSn-------------------------IEDMLPMMKMVIYLVDKIkRFRLSKEG 402
gi 358339929  405 Q-----KVLIFGFR-VG----T--KGSvsv---------------------edMETTAPLFQFIFYVIDKVhRLRLGKEA 451
gi 576694947  370 Q-----KVLIFSFI-L--------DEKd-------------------------VEAMKPLFNFVFYLTEKTrKLRLGKEA 410
gi 1084301063 380 Q-----KALIFALRyVP----T--TTKsksfstsltssnnnangnlnqhhqqpIESATALFHFIFYVIEKVrRFRLSKEG 448
gi 198415840  348 V-----KQITLVIN-LP----E--KPSe-------------------------IGEMVPLLKMLIYLSDKLkKLRLSRDS 390
gi 674590128  360 KpnevqKVLICSFI-L--------KEDe-------------------------IENMKPLFNFVFYLLEKVrKVRLLKDA 405
gi 1133460060 318 E-----KRIHLTFK-LP----Sd------------------------------LDQTTELLDFALKLLDHVkHIRLSREA 357
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74632713   346 AKKIRATRETEIKKIQKVADEERAEEEAEKRAAAKKEADTKaISSLSPEAQRKAEQKLREKEARK 410
gi 675860370  383 KLKADKNRQKVLELYQKATHSQRSEAAQNRKEEKRRAEKEKiMNEDDPDKQRKLEEKNLKKEAKR 447
gi 156391215  329 RAKADKNRRELEENLLKQTHLQRQEAAQLRREEKRRADKERmMAEDDPDRQRRLEERVNKAEAKR 393
gi 115871278  403 KVKAEKIRAKVAESYVKLAHAQRQELAQQRREDKRRVEKDRlLNEEDPDKARRLEDKQYKKDMRK 467
gi 358339929  452 KAKSERNRQRAYDTRLKAVHSLRQEAAQTRREERVRANKERiMAEEDPEKARRLEEREQRkekak 516
gi 576694947  411 KAKSDRARTKVSETLLKSVQAARQEAAQNRRDEQRRAVKERiMTEEDPEKARRLEEREQKRENRK 475
gi 1084301063 449 KAKSERNRQRAHDSHLKLMHSQRQEAAQNRRGERLRAAKERiMAEDDPEKARKLEEKEQRkeksk 513
gi 198415840  391 QIKADKHRADVADRYLKQTHAQRQEAAQQKKEEKARALKERmMNEEDPEKQRRLDEMIQRKEQnk 455
gi 674590128  406 KARADKARSKVYENAMKSVHQQRQEAAQNRRDEQRRAVKERiMAEEDPEKARRLEEKeqkkekkr 470
gi 1133460060 358 KDKATKNRQLVVQEQEKLQHQQRQEAAQQRKEEKKKAEKEKmLEETDADKVRKWEEKEYKKQMKK 422
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