Conserved Protein Domain Family
Swi3

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pfam07962: Swi3 
Replication Fork Protection Component Swi3
Replication fork pausing is required to initiate a recombination events. More specifically, Swi1 is required for recombination near the mat1 locus. Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks. The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling.
Statistics
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PSSM-Id: 311767
View PSSM: pfam07962
Aligned: 130 rows
Threshold Bit Score: 61.3588
Threshold Setting Gi: 0
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59800385    51 KFDEERLISEN-GIPKLRKMM-RKVKL--KG-KG--HEAKDLKQLLGMYHIWTHELYPRATFDDSISYLKTLGKHRSVKV 123
40_pfamImport   1 SLDVERLLNPEnGVPYMLKTFsKHVRF--SNkPG--METRNLRLLMDHYDAWMDQLMPKMSLSNVVDTIERLGHKAAVRT 76
38_pfamImport   1 KDRD--VLATN-GIRKLYKNL-KSSKF--SAkHS--NK-TNLELFFGIYSKWSKEINPAISIEDSIVKIEVLGKSKLVKN 71
gi 74854137   238 KDKD--LLSFK-GVSKLYNSL-KLSGF--STkQS--NK-ANLEKLFGIYSKWTKELNPYVTLENSIINVERLGRNRIVRN 308
78_pfamImport   1 ILTDSTLVSGE-GLEKIYKTFpFQVSG--DVa-G--QEAKALGSLIKMYKQWAYDLYPGLNFEDFVDRTEALSKGHVVQG 74
25_pfamImport   1 MLRESHLVSAE-GFKKVHRTFpYQVSA--DVs-G--RESQSLASLINMYKQWAFDLYPGLNFEDFIDRAETLGKGHQVQG 74
28_pfamImport   1 AFSENHLVKEK-GLWQIYKDFpQKCQY--KG-RG--REAEFLRGLMVAYKEWGYQLYPGVAFEDLACRTEKLGGRARTRS 74
gi 124454162   18 RLKPEQITDPQkGVVYLYNLC-KDYRF-----GN--DELDELNKYMHVIEEWHYQIMPKYDFDYFTNRLQKFGGNNSVQT 89
72_pfamImport   1 KADM--LTNQErGIKFLYENI-EKAKLfdKNeKGifDELKALDKLVNYYKGWHFHFMPKYSYQYFLDRCTEFGKTSLIKT 77
62_pfamImport   1 VLNERTLTGPT-GISALKETF-KDFKP--DP-KN--DPYANLEKMMKKYAYWAHLMFPNMKTEDVLSRVETLGTRKHVKL 73
                          90
                  ....*....|
gi 59800385   124 RRRGWINEIA 133
40_pfamImport  77 YLTDLRLSQA 86
38_pfamImport  72 HIEDIKHGVY 81
gi 74854137   309 HIDDLKNGIV 318
78_pfamImport  75 LMNELRTREM 84
25_pfamImport  75 LMIELREKEK 84
28_pfamImport  75 LLRELRDTER 84
gi 124454162   90 HLQFLRKAHK 99
72_pfamImport  78 YMNNVRRIHK 87
62_pfamImport  74 YVTKQRLGMD 83
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