Conserved Protein Domain Family
zf-C3HC

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pfam07967: zf-C3HC 
C3HC zinc finger-like
This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.
Statistics
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PSSM-Id: 311772
View PSSM: pfam07967
Aligned: 24 rows
Threshold Bit Score: 115.925
Threshold Setting Gi: 74683528
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74586457  102 PYDLSSLLARLKTFNSLNWk---------SIDDSSINELKCAINGWKCvsFGvk---etKNHLLCTYCNQQLIL------ 163
gi 74683528  119 PFSALSLLSRLMTFQPYTYs---------PQHPLTLSPVRAAMKGWVN--EG-------REGLKCDVCGARWGL------ 174
gi 74582911   40 PWSREEFLRRLLTYRSR-Wa---------YVNDPQIGEINCCLNGWLC--ES-------NNILVCDVCRNKINL------ 94
gi 122140223  72 sTSKEAFFSRVETYSSLKW----------AGKPSELSPLVCAKYGWVT--VE-------CDMLKCSSCQAFLCA------ 126
gi 75022383   48 YRDMETYHKIIKTYKAPTW------------YGCAVSPRDLADYGWAC--VK-------KDCVKCIECEQYLST------ 100
gi 74632378  109 PWSKEDFLDRVSTYTYQKYpi-------eTSLYPKLSPYNVARYGWKC--TS-------SKMLQCVSCGSYLAV------ 166
gi 268552741  47 iRDVEAYKKIIKTYKAPTW----------FG--CAVSPRDLADYGWEC--VK-------KDCVKCVECEELLCT------ 99
gi 190345445 109 PYSRPQLLHRLASYTALNWslpe---salASKSWEVSELKCAQNGWRC--VSirn-snlKNHLVCDVCHHQLILrynevh 182
gi 150865770 100 PFNADQLVARLKTFTALNWhipslpscegVVSENTLNELKCARNGWKC--VSfslnnntKNHLLCTTCNQSLVL------ 171
gi 116517250  65 aaNKEAFFNRVESYSCLKW----------AGKPSVLSPLRCARYGWIN--VD-------CDMLKCCSCQAFLCA------ 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74586457  164 -KFesndlhngnstivetpfdfqyL-SGKTFDESFQKKLVELYTKQIEnT-GHGPNCLWKNFETPiEEVYHLRqyL---P 237
gi 74683528  175 -Gg-----------------------LEKVRDEAMKSNLGERLAKGFE-E-RHEKNCAWRICASPgNLYEQLRhlV---H 225
gi 74582911   95 -TAlq------------------qVdAENDSLNELPEKTKERLEVSLK-E-EHQDNCLWRLHKFPpDIYHLSV------- 146
gi 122140223 127 -T------------------------LQPAFDFDRYKERCAELKKALC-T-AHEKFCFWPDSPSP-DRFGMLP--L---D 173
gi 75022383  101 -V----------------------LpNICKVSFNVYNSSLQDIHEKMT-T-AHRTTCKLRCGAPPfRIVEPTAkeV---M 152
gi 74632378  167 -V------------------------CGEEDDEATIKVVQDKYLGLIT-R-NHSSRCLWKNKPCS-ESLGSIMgnI---G 215
gi 268552741 100 -S----------------------LpNICKVSFNVYNSRLQEIHDQLS-S-AHRTTCKLRTGAPPiRFTEPTSkeI---M 151
gi 190345445 183 dSI---------------------FdFDVEEVAQLNVNLARSYLKQIT-TkAHGTACPWQSLETPlQGVYYMR--PflkN 238
gi 150865770 172 -KFsegqqqkey---safdydflkNsSIEASCNQLNNALHNKYLDQVVyE-GHSPSCSWRNFETPlEGIYYPRpyL---N 243
gi 116517250 120 -S------------------------IQATLDFQKYKGRISEVRQQLQ-T-QHEKFCSWPDFPCP-DRFWMVP--I---N 166
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 74586457  238 NTnQFLIQEYCK-----NLKNLI-------DNTLILQE 263
gi 74683528  226 PPiTSSLAPLAS--------HLLle----cLALPSLRL 251
gi 74582911  147 ---SAELVQVGR-----RFNSLStrl--vsTHLPEEMT 174
gi 122140223 174 EP-TVLVSEFLD-----RFQSLChl----dLQLPSLrp 201
gi 75022383  153 DGiQRRLSDSKK-----IIDEDLk------ADIPSDVN 179
gi 74632378  216 RL-RKDLGGKIAipegvEVTVDGqsvedffKKLLLEVD 252
gi 268552741 152 SGiQSRLSDSKS-----IEDDDFv------VHIPSDVN 178
gi 190345445 239 TN-ETLLAEYRK-----ALSGLVrh----wRVLESQIS 266
gi 150865770 244 KTnERLLRDYLK-----NLKNLMdngmilneyadslad 276
gi 116517250 167 EP-TVLLAAFLE-----RYKSACll----eQQLPAMKp 194
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