2WZS


Conserved Protein Domain Family
Glyco_hydro_92

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pfam07971: Glyco_hydro_92 
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Glycosyl hydrolase family 92
Members of this family are alpha-1,2-mannosidases, enzymes which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation.
Statistics
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PSSM-Id: 336884
View PSSM: pfam07971
Aligned: 729 rows
Threshold Bit Score: 382.973
Threshold Setting Gi: 502629823
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WZS_A       216 IGFK-TRkgeQ--VNARIASSFISFEQAAANM-NELGKdNIEQLAQKGKDAWNQVLGKIEVEGGNLDqYRTFYSCLYRSL 291
gi 524455676 218 VKFInSKgkkP--LELKIGFSFVSIENAKMNLeYEMFHkDFAQVAREADYTWEKLLSKIQVSGGTEReKKLFYSCLYHAF 295
gi 752739220 229 VDFLnNKgsrA--LELKIGFSFVSIANAKQNLeAEMLGkSFEQVRQEADNIWNKQLGHIQVEGGTQKqQTMFYSTLYRAF 306
gi 740774061 243 VSFN-ESde---eLELKLALSFVSIENAKQNLeAELAGkSFEEVKNEASETWENLLSKIKVEGGTDKqKSLFYSSLYRSF 318
gi 502455713 233 VHLA-DGnkgP--VEMKIGLSFVSTENAKQNLeKEIGQhSFDDIRHEATDKWEKLLSAVEVKGGTEKqRTMFYSCLYRSF 309
gi 326552637 235 VHLT-NEskaP--VELKIGLSFVSMENAKQNLlQEIGNkSFVEIQEEASRQWNEILSSIEVTGGTKKqKEMFYSSLYRSL 311
gi 495474768 233 LSLS-DQdagV--VTMKIGISYVSIANAKENLeSESIDaSFEEVQTAAEKEWDGLLSKISVKSDSRRdKEMFYTSLYRTF 309
gi 504032333 267 LDLT-TTageQ--VLVKIAHG-TSYEQAEQRLqSEDPGwDFDRVHRQAEDAWAAKLNQIEVEGGSEKeKMLFYSCLQHSF 342
gi 326552386 257 LRF---GtreGeqVNIKVGLSYTSVENARENLiAEASNlSFEDAKQRAYQRWNQYLGRIHVNGGKEAdKVKFYTGLYHAL 333
gi 503071032 260 LTF---NmekDsvLEIQTGLSYTSIANARLNLkTETNGkTFESVKQESKDDWNKKLNKIVVEGGKKEdRVKFYTGLYHAL 336
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WZS_A       292 LFPRKFYelDangQpihYSpyN--GQvlp----------gymFTdtgfWDTFRCLFPLLNLMYPSVNKEMQEGLINTYLE 359
gi 524455676 296 KWPALRS--DvnfE---YTdiK--GNvvnn--------gfnyYTnpsfWDDYRNKLVLLEMLSPEVTTDVIKSIIDKGEK 360
gi 752739220 307 LWPALRS--DvngE---YTdeQ--GRvcka--------dfryYTnpsfWDTYRNKLILLGMINPDVATDIIKSIIDKGEK 371
gi 740774061 319 LWPALRS--DvngE---FTdaS--GEvvnk--------gfryYTnpslWDTYRNKLVLLGMLSPDVTADVIQSLIDKGEK 383
gi 502455713 310 LWPALRS--DvngE---FSdaK--GKvvka--------dfnyYTepslWDTYRNKDVLLGLISPQVTLDVIKSMKDVGDK 374
gi 326552637 312 LWPALRS--DvngE---FTdaK--GNvdka--------dfnyYTepslWDTYRNKDVLLGLLAPQVALDVIKSMKDVGDK 376
gi 495474768 310 LWPALRS--DangE---FSdeA--GKiqkq--------dfkyYTipslWDTYRNKLVLLSILSPEVTGDVISSLINRAEI 374
gi 504032333 343 ASPRLVA--QkgeP---FVtrD--GTvtta--------tydrYNevpfWDTGRNQIVLLTLLEPKVKTDILHSQLDMARE 407
gi 326552386 334 LGRGLAS--DvngA---YP--KndGSvgripldevgkpihahYNtdaiWGAFWNLTQLWSIAYPEYYEDWIQSQLLVYKD 406
gi 503071032 337 LGRGLSN--DangD---YP--LseDKightalnekgkpkynhYNtdgiWGGFWNLSQVWALAYPDYFSDYIQSNIDFYKD 409
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WZS_A       360 s---GFFPEWASPG-HRGCMVGNNSASILVDAYMKgvKVDDikTLYE---------------GLIHGTEnvh---peVSs 417
gi 524455676 361 s--nGYMPTFFHg--D-------HASTFISGSWLRglHNFDlkRAYKlilknatvpgeggrpYLDE-------------- 415
gi 752739220 372 a--gGYMPTFFHg--D-------HASTFVAGLWLRgiKGFDlqRAYKlllknatvpgrggrpWLEE-------------- 426
gi 740774061 384 t---GFMPTFFHg--D-------HAAPFISGSYLRgiRDYDvqSAYQlllnnat-keggtrpHIAE-------------- 436
gi 502455713 375 t---GFIPTFFHg--D-------HGTSSIAGAYLRgiDNFDikGTYAtllrnan-vangarpFVTE-------------- 427
gi 326552637 377 t---GFIPTFFHg--D-------HGASSIVGAYLRgiNDFDvqGTYKlllrnan-asngarpYVDE-------------- 429
gi 495474768 375 t---GFVPTFFHg--D-------HGAPFIAGSYKRgiSNFDvqKAYSfllnnay-nakgpraHVEE-------------- 427
gi 504032333 408 sgymG------------TSFHGDNAVFMYLGDWERg-lDFDwaGTYE---------------YLRKNATdpagprgyLA- 458
gi 326552386 407 a---GWLGDGIATSkFVSGVGTNFTGLAIAAAYNVglRNYDvaLAYE---------------AVRKNELesekripgAGk 468
gi 503071032 410 t---GWLHDGTANGvFTNGVQTNFQGLLLASAYNVgiRDFDvkTGYE---------------AALKNELeyngrnlgNGk 471
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WZS_A       418 tgRlgyEYYNKLG----YVPY------------DVKi---nENAARTLEYAYDDWCIYRLAKELKRpKKEISLFAKRAMN 478
gi 524455676 416 --------YIKRG----WIAEkdtv----nvptQDEy---kGAVTKTVEYAYDDYAVALVAKELGD-QKNYNMLMKRTEN 475
gi 752739220 427 --------YLKQG----WIAEkdtt----nvptWDEy---kASVTKTQEYAYDDYATALIARELKD-KKNYQLLMQHSQN 486
gi 740774061 437 --------YIEKG----YISTpeve----nphvESKa---kAGVTKTLEFAYDDYAVALLAEELGK-QDDYKMLMKRTSN 496
gi 502455713 428 --------YIEKG----YISDpdia----nphvETKa---kAGVSKTLEYSYDDYSLAQIAKKLGD-TANYRILMARSKN 487
gi 326552637 430 --------YIQKG----YISDpdia----nphvETKg---kAGVSKTLEYAYDDYSLAQMAKKLGD-EVNYKRLIARSKN 489
gi 495474768 428 --------YIAKG----FISDpqve----nphvETKa---kAGVSKTLEYAYDDYSLAILADTLGD-KEHFQDLMSRSQN 487
gi 504032333 459 ------EY-MKNGwisdIIPPgn---------pSPPyaggkAGAATTLEYSWDDYAMAIYAKRLGK-QADYEMFLKRAQN 521
gi 326552386 469 ldV---GVFVEKG----FSPYiaddtgkpelnlHGSp----FGASHTLEYAFSSFAAAQFAKSLGK-KADFKRFSHLAKA 536
gi 503071032 472 ydL---SYFVKDK----YVPYkdt------iisNGWvf--nFGASHTLEYSFSSYAVAQMAKDKKD-EVNYEKLMKQADY 535
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WZS_A       479 YKNLFDKESKLMRGRNEDGTFQspFsplKW-GDa-fT----EGNSWHYTWSVFHDPQGLIDLMGGKEMFVTMMDSVF--- 549
gi 524455676 476 YKTLFDPSTGFWRGKIEDGSWItdFdpyYP--Yy--QymyrEANAWNALFFAPHDPEGMIKLYPNNKAVEDKLDSLF--- 548
gi 752739220 487 YKNLFDASTGFWRGRIADGSWIkdFdpwYP--Yy--AymyrEADAWNSLFFAPHDPEGMVALYPSKKAVELKLDSLF--- 559
gi 740774061 497 YKNLFDPSTGLMRGKLENGDWVpdFnaeYP--Yy--EymyrEANAWQSSFFAPHDTKGLIGLYKSEAEFEEKLDSLF--- 569
gi 502455713 488 YRNMFDPSTRFMRGRLENGEWIknFnpqYP--Yy--EymyrEANAWQVSFFAPHDMPGLIKLYGGPKPFESKLDSLF--- 560
gi 326552637 490 YRNVFDPTTKLMRGRLDNGDWItpFnpqYP--Yy--EymyrEANAWQVSFFAPHDMEGLIELYGGKKAFESKLDSLF--- 562
gi 495474768 488 YKNVFDPSINFMRGRLENGDWIspFdteYP--Yy--EymfrEANAWQVSFYAPHDMPGLVSLYGGPDMFEEKLDEFF--- 560
gi 504032333 522 YRNVFDSSIGFVRGKTEDGKWIapFdpgEPyYNfmmK----EASGWSTLWLVPHDVQGLANLLGGREKFAAKLDEFFstp 597
gi 326552386 537 WETLYDPSTKFIRPKDEEGNFLqdFdpfAP--WrgfQ----EGNAWQYTFYVPHNPKGLVNLIG-EKTFNDRLDSIF--- 606
gi 503071032 536 YKNLFDPVTKFIRPKLKNGSFIkdFdpmKG--WdgfQ----EGNAYQFTWYVPQDPKGLIDLVG-KPLFNERLETMF--- 605
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WZS_A       550 AvppifddsyygqviheiremtvmnMGNYAHGNQPIQHMIYLYDYAGQPWKAQYWLRQVMDRMYT--PGP-D-GYC-G-D 623
gi 524455676 549 Tepwrgye----------vdnmtgfIGNYCHGNQPGHGIPYTYYFIGKQEKAQAILDSLMEHYYDmgKDK-L-AYA-G-M 614
gi 752739220 560 Tqpnhgye----------awnltgfLGTYCHGNQPGHSIPYTYYFADKQEKAQVVIDSLLNHYYGmgEEG-L-AYA-G-M 625
gi 740774061 570 Sipwnadyi---------arnvssfIGQYCHGNQPDHSFPYLYTFIGKQEKSQMYLDSIMNRFYGmgEWE-N-AFC-G-M 636
gi 502455713 561 Tvpwnpnyi---------arnvetmIGQYCHGNQPDHEAPFAYYFINKPEKSQKIIDTILNSLYGvgDDG-I-ALC-G-M 627
gi 326552637 563 Tipwnptyi---------arnvetmIGQYCHGNQPDHEAPFAYYFIEKPEKSQRIIDYILNNLYGigDEG-L-ALC-G-M 629
gi 495474768 561 Tkpwnpnhi---------arnvstfIGQYCQGNQPDHEAPFAYYYVNKPEKSQAILDKIMNELYGigPEG-L-ALS-G-M 627
gi 504032333 598 Ytakgvc------------rdctglVGEYVQGNQPDQQAAYYYDWAGQPWKTQALVRRILREMYG--SDKtGyAFP-G-M 661
gi 326552386 607 Resqknvfggg-----keidafagiQGLYNHGNQPNLHVAWLFHASGRPDLTQKWVHAICDEFYG--TDG-IhGYGyGqD 678
gi 503071032 606 Ndaqksmfggg----seeihsfsgvEKLYNHGNQPCLHNPWLFNYSGKPWLTQKWVRTICNEFYG--TEP-LhGYGvGqD 678
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WZS_A       624 EDNgQTSAWYVFSALGFYPVcPGT---DEYVMGTPLFKKATLHF----ENGNSLVIdaPnNSteNfYIDSMSFNGADHT- 695
gi 524455676 615 DDAgEMSSWYVFNAIGLYTYsPAD---PDYIITVPLFDKVKFYL-----NDKPFTIvkQg---kGrKIREITYDNKVIN- 682
gi 752739220 626 DDAgEMSSWYVLNAIGIYTYsPAD---PQYIVTVPLFNKVRFTLg---TTGNTFTIrrEg---sGrKISQITVGGKPLK- 695
gi 740774061 637 DDAgEMSAWYVFAAMGIYPYsPGD---AEYIVSVPLFNSVKLDL----GEQSEFKIskTn---sGrKIKDLTIDGNLVE- 705
gi 502455713 628 DDAgEMSAWYVFSAAGLYTFsATD---PEYLVTVPLFDEVKWRT----STNKILTIthQg---kGrKMTAIKVNGKPIK- 696
gi 326552637 630 DDAgEMSSWYVLSALGLYTYsATD---PTYLVTVPLFDKVKWHR----MGGKELTIikAg---eGrVLKNIIVNDKPNK- 698
gi 495474768 628 DDAgEMSSWFVCAAVGLYPMsPAD---ADYLVTVPLFDDVTWKV----DNGNDLVIlnPn---rGrKLQEIKVNGKTLD- 696
gi 504032333 662 DDQgSTSSWYVMSAMGFYTVdPSS---PNYILGSPLFTHTVMHM----GNGKTFEMvaNhNSekNiYIQSATLNGKAWN- 733
gi 326552386 679 EDQgQLGAWYVLAGMGLFDVaGLTapnPSLQIGTPLFDEVVINLpl-aERSRKFTIktKrSKngPcYTKSAKLNGKVLEa 757
gi 503071032 679 EDQgQLGAWYVMASLGLFDVqGHTsanPSFQFGSPLFERITIQLdndyYEGKELVLetKnQSqeNlYIQSLSFNGKPVNn 758
                        570       580
                 ....*....|....*....|..
2WZS_A       696 -KnYLRHEdlfKGGTIKVDMSN 716
gi 524455676 683 -GyFISHEqlqKGKKLVITVE- 702
gi 752739220 696 -GwFVPHAqlaKGAEMLIKTE- 715
gi 740774061 706 -GyFVSHEqlkKGKELIILTE- 725
gi 502455713 697 -GyFVPHDlfkNGGKIEVVTK- 716
gi 326552637 699 -GyFVSHDlflKGGEIRVETK- 718
gi 495474768 697 -GyFVGHDlfrKGGKIELVTN- 716
gi 504032333 734 -KpWFSHSdieAGGKLVLNMGP 754
gi 326552386 758 lQ--LPFEaliKGGTLELNMVP 777
gi 503071032 759 nW--MYRKeliNGGKLIFELGP 778
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