3NO8,3HWJ,3GBW


Conserved Protein Domain Family
PHR

?
pfam08005: PHR 
PHR domain
This domain is called PHR as it was originally found in the proteins PAM, highwire, and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.
Statistics
?
PSSM-Id: 336899
View PSSM: pfam08005
Aligned: 79 rows
Threshold Bit Score: 78.0199
Threshold Setting Gi: 759172639
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NO8_A          19 RFQQVESRWgYsGTs-DRIRFSVNK-----RIFVVGFGLYGSIHG--PTd------------YQVNIQIih--------t 70
gi 124451279   219 RYQLTYEQwnlkEt--DAICLRSKRk---hDIWLSGVGLYEITTWpdSE-------------LTFQVQIfe-------gs 273
gi 124460115   219 RYQLTYEQwnlkEt--DAISFRSKKk---hDIWLSGVGLYEITTRsgITtshl-----rfkyLKVQMSIgla-----lin 283
gi 402590437   314 RFATLSDKR-C-NSreSKFCFKVDR-----QILVGGFGIFGFAPR--AGnllssvdssaaldWQTKVEIelfti-sddfq 383
gi 829196290   221 RFGQFLDNwtldGi--NAITFQQNQnmfekDIWLIGFGVFEAQNM--SAlps-------ppkLTVCLSEg---------- 279
gi 405960691   313 RFMQLDTKlkehTGrpDAIMFETSK-----PVWFHGVVVYGSFIE--QS-------------INIHVKIt---------- 362
gi 268637822  1566 RFGNSNSCwsysGYniDGISFTCDK-----DIYVKGIGVYGDKGK-----------------CSCTASYa---------y 1614
gi 1160567469 1444 RFNSTSSSwsydEMm-DAISFKADA-----DIYITGIGLYGDKGS-----------------YSARVGVt---------l 1491
gi 569379459   340 Nws-------agGLi-DAISFECDH-----SIYLCGIGLFLSKGS--N--------------ELTSVHIfn--------q 382
gi 541041768   283 RFPNLSGKR-C-NKreNRFCFTADR-----DIMVSGFGIYGFVPM--TKphisfmdpsvaleWQAQVEIqlnpyldsreg 353
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NO8_A          71 DSN-TVLGQNDTGFSCDGsa---sTFRVMF-----KEPVEVLPNVNYTACAT-L---K-GPD-SHYGTKGMRKVTHespt 135
gi 124451279   274 NLNsKKLIYQDKFVIKNDmefvnhIGKLYF-----TKAIKIEYDKPYTIALT-----PnQSClSYYGANGKFETDE---- 339
gi 124460115   284 CIFsKKVIYEDTFDVLPNidycnhIGKMCF-----NKAIKIEFDQPYTIALK-----PnQSClSYYGANGKLETEE---- 349
gi 402590437   384 SYNsKDLSVTETVVIQGT------MNDVKPvvasfRKPVPVLPNVSYTARMKfL---DtGVIqTYSGAKGIETATVpll- 453
gi 829196290   280 KIAeEKLILRQQIQLSNQiqfknkMATIYL-----EKALKLNPKYQYTLSIT-----SdQTYlTYAGFNGCVDTKD---- 345
gi 405960691   363 DARlTIIRELGQTFESVEse---eMHDVLL-----STPFETVPGSRYNVVVTiVgkfRh----LFRGIAGKRSLTFk--- 427
gi 268637822  1615 GKNgGELFTNPTVSTQWGnkglhhIEEILW-----PNEVYLRRGQPLTVFIK-F---K-GGS-TSSGSRGKSTVTV---- 1679
gi 1160567469 1492 GQSaQSFNSTNSVNVSWSnktaryIHRIDL-----PEPFQLGANEIMTVFTK-I---S-GPS-SSSGYKGKESASA---- 1556
gi 569379459   383 QTNeTIFKTNPNEVTTWPyeatpnITPVKYlfrqgEHKISIRASVRYTIQIR-----QkSADvTYGIINNQQHIFVhq-- 455
gi 541041768   354 TPNaNCVSAVETVLLKGI------MGDVKPlvasfSKPVVVPANISYVAGMKfM---SdATVqTYGGKDGVEFATVqlp- 423
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
3NO8_A         136 tgAKTCFTF---CYAa-GNNN--------GTSVEDGQ-IPEVIF 166
gi 124451279   340 ------FQFeepTFSqeFSDN--------STTINQGV-VPQFFY 368
gi 124460115   350 ------FQFsepSFTqeFSDN--------STTINQRRvIPHFyy 379
gi 402590437   454 fdEKINFHFe------sYSRNsynhccynNVSHCEGQ-LPEIHF 490
gi 829196290   346 ------FTYfesQIVrpISNN--------GTNTMMGQ-FPYLVY 374
gi 405960691   428 -dSEITF-----YESg-CSSN--------GTTVAEGQ-IPGFLl 455
gi 268637822  1680 --QDCKFTF---CEGiiKSDN--------GTSVSSGQ-IPTILF 1709
gi 1160567469 1557 --EGVNFKF---MTSrvNSDN--------GTSLNSGQ-IPTIFF 1586
gi 569379459   456 -pSKIEFQF---FDShdNSDN--------GSTVNCGV-IPCFYF 486
gi 541041768   424 fdETVTFHFqcfKNS--YGNE--------DVSRFEGQ-LPEIYF 456
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap