Conserved Protein Domain Family
PHR

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pfam08005: PHR 
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PHR domain
This domain is called PHR as it was original found in the proteins PAM, highwire, and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.
Statistics
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PSSM-Id: 311801
View PSSM: pfam08005
Aligned: 82 rows
Threshold Bit Score: 79.9663
Threshold Setting Gi: 759172639
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NO8_A         19 RFQQVESRwg--ysGTs-DRIRFSVNK-----RIFVVGFGLYGSIHG--PTD------------YQVNIQIih------- 69
64_pfamImport   1 RFPNLSGKr----cNKreNRFCFTADR-----DIMVSGFGIYGFVPM--TKPhisfmdpsvaleWQAQVEIqlnpyld-- 67
gi 124451279  219 RYQLTYEQwn--lkEt--DAICLRSKRk---hDIWLSGVGLYEITTWpdSE-------------LTFQVQIfeg------ 272
gi 124460115  219 RYQLTYEQwn--lkEt--DAISFRSKKk---hDIWLSGVGLYEITTRsgITTshlr-----fkyLKVQMSIglal----- 281
40_pfamImport   2 RFGKSQQGwv--lsEt--EALTFEINKe---qDIWLKGFGMYEVISL--PKDctndr--enngnLNLDIKLfqg------ 64
53_pfamImport   2 RFGQFLDNwt--ldGi--NAITFQQNQnmfekDIWLIGFGVFEAQNM--SALpsp-------pkLTVCLSEgk------- 61
7_pfamImport    2 RFGKVDLGktwntgNFgpDAIAFTVDRa----GISIVGACVYSGSGS-----------------YEYQLELlydshhsth 60
38_pfamImport   2 RFMRVNQSrawntgNGspDAICFTVDRs----GVMLVGVCVYGGPGN-----------------YEYSIELlndvrqsrs 60
34_pfamImport   2 RFMRVNSArswstgNGspDAICFTVDRp----GVALVGACVFVGSGL-----------------YDYTIELlhdmrtsse 60
41_pfamImport   1 RFATLSDKr----cNSreSKFCFKVDR-----QILVGGFGIFGFAPR--AGNllssvdssaaldWQTKVEIelftis--- 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3NO8_A         70 -----------tdSNTVLGQNDTGFSCDGsa----sTFRVMF-----KEPVEVLPNVNYTACAT-LK-GPD-SHYGTKGM 126
64_pfamImport  68 -------sregtpNANCVSAVETVLLKGI-------MGDVKPlvasfSKPVVVPANISYVAGMKfMSdATVqTYGGKDGV 133
gi 124451279  273 ----------snlNSKKLIYQDKFVIKNDmef-vnhIGKLYF-----TKAIKIEYDKPYTIALT--PnQSClSYYGANGK 334
gi 124460115  282 ---------inciFSKKVIYEDTFDVLPNidy-cnhIGKMCF-----NKAIKIEFDQPYTIALK--PnQSClSYYGANGK 344
40_pfamImport  65 -----------gnTSGKVLHEETIQISRDlhanydhIIELNL-----QKPLKLETKQKYTITMK-PN-RDCiSYFGYNGC 126
53_pfamImport  62 ------------iAEEKLILRQQIQLSNQiqf-knkMATIYL-----EKALKLNPKYQYTLSIT--SdQTYlTYAGFNGC 121
7_pfamImport   61 sh-tyshshrwevLESIVGSYDQTAVrq-------hMAELRF-----NRAVLLKENHRYALRLC-SQ-GAr-TLSGDCGQ 124
38_pfamImport  61 speemnpahcwvsVEVAHGAFSGAECqh-------dMVQLKF-----DRPILLKEEIRYAIRLC-NH-GGr-TANGDCGL 125
34_pfamImport  61 e---snathcwvsLEAADGSFSSGDAhh-------eMVNIKF-----NKPVLLKDEIRYALRLC-CE-GAr-TASGDCGL 122
41_pfamImport  67 -------ddfqsyNSKDLSVTETVVIQGT-------MNDVKPvvasfRKPVPVLPNVSYTARMKfLDtGVIqTYSGAKGI 132
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
3NO8_A        127 RKVTHespttgAKTCFTF---CYAa-GNNN--------GTSVEDGQ-IPEVIF 166
64_pfamImport 134 EFATVqlp-fdETVTFHFqcfKNS--YGNE--------DVSRFEGQ-LPEIYF 174
gi 124451279  335 FETDE----------FQFeepTFSqeFSDN--------STTINQGV-VPQFFY 368
gi 124460115  345 LETEE----------FQFsepSFTqeFSDN--------STTINQRRvIPHFyy 379
40_pfamImport 127 YQTSD----------FKYydsIVSkdLKNN--------SSGVLLGQ-FPVFY- 159
53_pfamImport 122 VDTKD----------FTYfesQIVrpISNN--------GTNTMMGQ-FPYLVY 155
7_pfamImport  125 SSLRGp----cGTVTFRF---YPCd-LSFN--------GTTPARGQ-IPAILY 160
38_pfamImport 126 PSVKGp----dG-TTFRF---ASCs-LSFN--------GTTLARGQ-IPCLVY 160
34_pfamImport 123 PAVTGp----dG-TTFQF---SSCs-LSFN--------GTSIARGQ-LPCLIY 157
41_pfamImport 133 ETATVpll-fdEKINFHFe------sYSRNsynhccynNVSHCEGQ-LPEIHF 177
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